Liz Pekas, PhD

Associate Director, Medical Affairs | Diabetes, Obesity, and CVDs | Physiologist | Powerlifter🏋️‍♀️🫀🫁🏃🏼‍♀️

[Francesco Rubino @FRubinoMD]

The @TheLancetEndo Commission said: preclinical obesity = risk. Clinical obesity = active disease >> Treat each accordingly. Evidence-based, standard medicine. Not complicated.
Now a @NatureComms study confirms preclinical obesity = risk; it does not show it is disease. Exactly the Commission’s position.
Spinning this as “proof” that the Commission’s framework is confusing and dismissing a legitimate scientific debate held @ObesityCan as “unhelpful”—frankly makes little sense…unless the aim is to foment controversy, for whatever reason.
That is what’s truly unhelpful

[ADA Professional Publications @ADA_Pubs]

📢 New journal launch
The first article in Diabetes, Obesity, and Cardiometabolic CARE has been published.

📝 "Pharmacologic Treatment of Obesity in Adults: Standards of Care in Overweight and Obesity" presents evidence-based guidance for medication use as part of comprehensive, person-centered obesity care.

🔗 Read more: https://t.co/UtaeCgF7Zy
#DOCMCARE #ObesityCare #StandardsOfCare

[Prof Kamlesh Khunti @kamleshkhunti]

Our Delphi published

Nutritional and lifestyle supportive care recommendations for management of obesity with GLP-1 - based therapies: An expert consensus statement

https://t.co/gGa2Ed3OQo

with @TinaVilsb et al

[Circulation @CircAHA]

AHA/ACC have released the 2025 High Blood Pressure Guideline, emphasizing prevention and early treatment to reduce cardiovascular disease risk.

Read the Guideline in @HyperAHA & @CircAHA and check out our hub with commentaries and more:
https://t.co/RUfDglhsCr...

[Prof Kamlesh Khunti @kamleshkhunti]

Staying active = living longer

Meta-analysis 85 studies:

✅ Consistent or increasing physical activity over adulthood linked to:

🔻20–40% lower all-cause mortality
🔻30–40% lower CVD mortality

🩺 Even PA below guidelines offered benefits

https://t.co/urhtZDnfbN

[Prof Kamlesh Khunti @kamleshkhunti]

📊 Tirzepatide: Don’t stop at 12 weeks!

Post-hoc analysis

🕒 Early vs Late Responders (Week 12)
🔹 Early: ≥5% weight loss → 82%
🔹 Late: <5% weight loss → 18%

📉 But by Week 72…
✅ 90% of late responders achieved ≥5% wt loss
📈 Most by ~25 weeks

https://t.co/BKcPueD3m3

[Radcliffe CKM @RadcliffeCKM]

💡Dr @ArunJSanyalVCU shares insights from the phase 3 ESSENCE trial examining #semaglutide 2.4 mg for metabolic dysfunction-associated #steatohepatitis.

📽️Watch here👉 https://t.co/0WDRvUsRBk

#MASH #CKM #CVRM #CardioX #CardioEd

[Jonathan G. Stine, MD MSc, FACP @JonathanStineMD]

The muscle–adipose–liver axis is critical, yet underrecognized, in #MASLD.

Sarcopenic obesity affects ~50% with #MASLD and drives ⬆️ ASCVD and liver fibrosis.

@ChannapragadaV and I argue it's time to standardize definitions and intervene early:

https://t.co/q6f465tgJZ

[ADA Professional Publications @ADA_Pubs]

🚨 New ADA Consensus Report: A multidisciplinary call to action on NAFLD and MAFLD in people with diabetes. Learn how early detection, screening, and team-based care can change outcomes.
📰 Read now: https://t.co/nib1VROEIP
#Diabetes #NAFLD #MAFLD
@AmDiabetesAssn @ADA_DiabetesPro @DiabetesCareADA

[Prof Kamlesh Khunti @kamleshkhunti]

Study showing 98% of individuals identified as having obesity based on BMI have excess adiposity.

https://t.co/pgmvS0pH6W

[Prof Kamlesh Khunti @kamleshkhunti]

please do help Zara our PhD student with this study is you are able to
Thank you

[Circulation @CircAHA]

Compared to low-volume physical activity, high-volume physical activity is associated with a lower risk of all-cause mortality but similar risk for clinical CAD events. https://t.co/DyBUpmPavR

[American Diabetes Association - DiabetesPro @ADA_DiabetesPro]

Happy World Liver Day! The liver is often overlooked in diabetes care.
New guidance from @AmDiabetesAssn is coming soon—stay tuned!

#WorldLiverDay #LiverHealth #DiabetesCare

[Liz Pekas, PhD @physliz]

@KatyWala @AHAScience @AANmember WOO!

[UNO College of Education, Health, & Human Sciences @UNOCEHHS]

🎉 Help us congratulate Dr. Adam Rosen who was selected as the new director of the School of Health & Kinesiology after a national search!

[Prof Kamlesh Khunti @kamleshkhunti]

For all those #coffee lovers

Drinking coffee in the morning may be more strongly associated with a lower risk of mortality than drinking coffee later in the day

Have it am and pm - to be on the safe side 😊

https://t.co/preWdwVVXJ

@mmamas1973

[Liz Pekas, PhD @physliz]

FINALLY back to (light) squatting and it feels so good 🙌
Last set 6x3 @ 205lb

[Prof Kamlesh Khunti @kamleshkhunti]

Great to see post trial follow-up of a CVOT!

EMPAKIDNEY

Empagliflozin continued to have additional cardiorenal benefits for up to 12 months after it was discontinued.

@NEJM

[Prof Kamlesh Khunti @kamleshkhunti]

Now data on metformin benefits and hearing loss!

Metformin use is associated with a dose-dependent reduction in hearing loss risk and lower mortality in people with T2 diabetes!

Metformin keep giving!

https://t.co/hZm0Ktdvb6

[Scott Isaacs @scottisaacsmd]

Intermittent fasting at any time of day is good for losing (some) weight but does not reduce visceral adipose tissue.
https://t.co/usAO7av50c