Geoff @ Picodesic

Picodesic makes biomedical animation.
End-to-end by one animator.

[Geoff @ Picodesic @picodesic]

@_Wienman_ love the toon-shaded look. Easy on the eyes, better for comprehension I find especially when molecular dynamics motion is added

[Geoff @ Picodesic @picodesic]

New reel, new logo, new site. Who dis?

[Geoff @ Picodesic @picodesic]

@town_in_new 😮😳🫣

[Geoff @ Picodesic @picodesic]

@town_in_new 🤯

[Geoff @ Picodesic @picodesic]

@town_in_new Perfect colors

[Geoff @ Picodesic @picodesic]

@town_in_new Just amazing. Is this using openframeworks?

[Geoff @ Picodesic @picodesic]

@EricTopol @tylercowen @MargRev @cowenconvos @TheFP @bariweiss @patrickc Is this a photo of a Penrose triangle?

[Geoff @ Picodesic @picodesic]

This is probably the pinkest/orangest scene I've ever done (thank you, ACES). Had chatgpt o3 write this scene's description, which sounds accurate:

Cell‑free therapy at the blood‑brain barrier: Nanometer‑scale EVs bind to endothelial receptors and undergo transcytosis across the tight junctions of the BBB. Once inside brain parenchyma, they deliver neurotrophic factors (BDNF, GDNF, NGF), anti‑inflammatory cytokines, and regulatory miRNAs (e.g., miR‑124) directly to injured neurons and glia. The cargo dampens neuro‑inflammation, promotes neuronal survival, and supports synaptic repair—achieving targeted regeneration without the risks associated with whole‑cell therapies.

[Geoff @ Picodesic @picodesic]

There is more. These mysterious guys are fibroblasts. Activated by EV growth factors (TGF‑β, PDGF‑BB, FGF‑2) they are depicted here remodeling the extracellular matrix (ECM), actually pushing the collagen fibers around as they migrate through it, secreting matrix‑metalloproteinases (very cool name), which slice damaged collagen into smaller fragments. The fibroblasts realign and synthesize new fibers—restoring the matrix’s strength and flexibility.

This is the type of thing that makes your skin look nice.

Or if this ECM is destined to be mineralized into trabecular bone (which we fly through at the end) osteoblasts will be doing the maintenance job instead, also receiving EV growth factors.

[Geoff @ Picodesic @picodesic]

Got a m4pro mac mini w 48gb ram a few months ago just so I could keep working on comps/edits and fire off teamrenders to my pc (of which I’ve built my own for 15+ years). It’s a third the price of any pc i’ve built and now I use it for everything but redshift renders and upscaling in topaz. Will grab an Ultra when possible and enjoy lookdev on that too.

[Geoff @ Picodesic @picodesic]

Ok bear with me on this one. This cell-free therapy scene starts out with some swelling hepatocytes (liver cells) nearing the point of cell death. Yes, they're arranged in these unbelievable hexagonal, cartridge-like structures called liver lobules, processing waste all day long.

We drop into a portal venule and follow an EV into the porous hepatic sinusoid, where it directly fuses with a swelling hepatocyte. Delivered growth factors (HGF, EGF, TGF-β), anti-inflammatory cytokines, protective miRNAs, and signaling molecules like mRNA help prevent cell death and coordinate the regenerative response between cells.

[Geoff @ Picodesic @picodesic]

Another cell-free therapy scene with a lot going on: Damaged muscle tissue releases an enhanced payload of growth factors (VEGF) delivered to damaged cells by EVs, triggering angiogenesis. Tip cells grow toward the damage, extending the existing capillary network. Myosatellite stem cells receive HGF from EVs, differentiate into myoblasts, and migrate to the tear in the muscle fascicle to accelerate repair...

[Geoff @ Picodesic @picodesic]

@cgpov I actually want this for the bissell ad I’m working on though.

[Geoff @ Picodesic @picodesic]

This is a scene from a recent production on cell-free therapy, an improved form of stem cell therapy. It shows a cross-section of an inflamed joint's synovial membrane. Extracellular vesicles (EVs) travel via the bloodstream to the site, fusing with resident cells to reduce cytokine production...

[Geoff @ Picodesic @picodesic]

@jessesingal objects

[Geoff @ Picodesic @picodesic]

@alexolegimas It’s a play on those hydraulic press vs objects videos that are popular now and the fact that it’s the thinnest apple device ever, couldn’t be thinner you see… I’m not even an apple fanboy, but the histrionics over this are even more theatrical than the ad.

[Geoff @ Picodesic @picodesic]

@tracewoodgrains Ugly is funny. American cartoons made partially for adult consumption are made to be funny. They’re caricatures of types of people. These other cultures with beautiful cartoons don’t seem to be as concerned with humor as a primary form of entertainment.

[microscopic images. @microscopicture]

various ciliates (single celled organisms) under the microscope

[Geoff @ Picodesic @picodesic]

@bryan_caplan It’s playful, light, and makes me want to build something, which works in its context. Technology centers are the place for this style.

[Smart Biology @SmartBiology3D]

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