Frankie

Geneticist - all tweets are my own

[Frankie @PolymorphicGod]

@dccommonsense Dan I Love what you do for the world. I don’t always agree but you’re a national treasure.

[Frankie @PolymorphicGod]

@landau_lab @LGMartelotto Exceptional work from an exceptional team! Congrats!

[Dan Landau @landau_lab]

Big, beautiful trees!!

SMART-PTA for whole-genome+transcriptome on thousand of single cells from the normal human esophagus 🤯 Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life.
https://t.co/pciw5yME0x

[Luciano Martelotto 🛠🧬💻🇦🇺 @LGMartelotto]

YES!!! It’s out! 🔥

One of the most amazingly beautiful collaborations.

I’ve admired @AnnaEnim since her original GoT - so much so that I flew from AUS to Cornell just to meet her in person (she’s learning this now!). Instant connection. Many coffees, visits, and brainstorming years later…

👉 GoT just went to the next level.

-What’s new

We developed Genotyping of Transcriptomes for multiple targets and sample types (GoT-Multi) - a next-gen single-cell multi-omics platform that:

•Links somatic genotypes to whole-transcriptome states in thousands of cells
•Works beautifully on FFPE tissues (hello, clinical archives!)
•Uses probe-based ligation + ML-optimized genotyping

In short - high-throughput, scalable, and accessible single-cell genotype–phenotype mapping.

-What we found

Applying GoT-Multi to Richter transformation (CLL → aggressive lymphoma):

•Mapped 27 mutations across thousands of single cells
•Reconstructed clonal architectures and their transcriptional programs
•Found that distinct genotypes - including therapy-resistant subclones - converge on an inflammatory state
•Discovered hints of subclonal cooperation, where small clones may actually support the fitness of others

Different genotypes. Shared transcriptional destiny. That’s how cancer learns to resist.

-Why it matters

GoT-Multi finally bridges the gap between clonal architecture and cell-state heterogeneity - directly, scalably, and even from FFPE samples.
It opens the door to retrospective clonal tracking, precision biomarker discovery, and spatial-genotypic integration.

Proud, grateful, and honestly blown away by what this collaboration achieved. None of this wouldn’t have happened with the amazing talents of Minwoo and Mirca…two incredible talented next generation scientists!

This is what happens when technology meets persistence and vision.

#GoTMulti #SingleCell #MultiOmics #FFPE #CancerEvolution #CellGenomics #Innovation #TeamScience

[Frankie @PolymorphicGod]

@dccommonsense Agree that’s what independent means. Who the hell is ever Neutral? Don’t say Switzerland 😆

[Frankie @PolymorphicGod]

@ufc @SugaSeanMMA Love Aljo - not sure why he gets hate. 90/100 times he wins this fight IMO

[Frankie @PolymorphicGod]

@NoContextHumans The hours

[Alejandro Montenegro @aemonten]

PIs: "but you're still coming to the lab, right?"

https://t.co/f9T22D6LrX

[Frankie @PolymorphicGod]

@notSoJunkDNA Goodnight!

[Frankie @PolymorphicGod]

@SJosephBurns All of them

[Dan Landau @landau_lab]

Great news to start the year for the amazing @C2iGenomics team! 🥂🥳

#DreamComeTrue for a physician scientist to see an idea once drawn on a blackboard moving closer to helping patients

https://t.co/WLuaFDsDdm

[Frankie @PolymorphicGod]

@BillyM2k

[Frankie @PolymorphicGod]

@lionisfun @ufc True - great performance by Drew. Tough sport. Still love what Bobby brings to the sport.

[Frankie @PolymorphicGod]

@RampCapitalLLC Yikes

[Frankie @PolymorphicGod]

@SJosephBurns Stress

[Frankie @PolymorphicGod]

@fdmts Identical twins have different fingerprints 😂

[Frankie @PolymorphicGod]

@RepAOC @SenSanders @RepBowman @RepCori @RepRashida @RepDonaldPayne I’m not 7 days is still a crime but good work

[Tuuli Lappalainen @tuuliel]

Huge congratulations to Molly Martorella @mollymozzarella for a stellar defense of her PhD thesis today! 🎉 @nygenome @Columbia

[Björn Schumacher @schumacherbj]

The supplementary figures https://t.co/gTE2WqPtsQ