New @biorxivpreprint from us + Ionis: how ASO activity is distributed across cell types in deep brain regions of NHP https://t.co/cnZNCaHDiV
The take-home message in one figure👇
Padova, @GalileoFest
Evento di Fondazione Telethon, 9 maggio ore 21
“La sfida dei prioni: dalle ombre della biologia alle luci delle nuove terapie contro le malattie neurodegenerative”.
@prionicus , @UniTrento , con Nicla Panciera giornalista scientifica https://t.co/JZHK0ZrG2Y
Check out this article just published in @NatureComms Prion protein promotes copper toxicity in Wilson disease.
Great teamwork with Roman Polishchuk @Tigem_Telethon@prionicus@MarioNegriIRCCS https://t.co/McBFVnkj8J
Today we report in @NatureMedicine the development of a base editing strategy for prion disease, currently a fatal and rapidly progressing neurogenerative condition with no effective treatment. @PrionAlliance@DevermanLab (1/13)
https://t.co/jYVDj7JPBZ
A new gene-editing treatment extends lifespan by about 50 percent in a mouse model of prion disease and could lead to a preventative, one-time treatment for the deadly neurodegenerative disorder. https://t.co/s0tX7gbC4g
Cryptic phosphosites buried in protein cores may become exposed during folding, triggering degradation. Their evolutionary conservation and links to cancer mutations suggest a pivotal role in health and disease. #ProteinFolding#Phosphorylation https://t.co/n4fv5kER57
Fa piacere che Serra si sia accorto che quello economico è un potere a tutti gli effetti in grado di controllare la politica e che il capitalismo è dunque intrinsecamente anti-democratico. Dormiva comodamente da 20 anni sull'amaca e i rutti di Musk devono averlo svegliato.
Most of the people doing important work are people you’ve never heard of—they want it that way. Most happy people don’t need you to know how happy they are—they aren’t thinking about you at all.
I'm getting these funny death threats from Iranian bots, which are not really scary (and in funny Hebrew). If they really wanted to scare me they should have sent an email titled: "Cell Editorial Decision CELL-D-24-02485"