Susanne

[BryanRoth @zenbrainest]

Wow!!
https://t.co/jO27LPwfNT

[David Sykes @Z7biotech]

Visualization of membrane localization and the functional state of CB2R pools using matched agonist and inverse agonist probe pairs - now published in Chemical Science https://t.co/rtOCB5xP3u

[RCNS MedChem Research Group @keserulab]

Read our @NaturePortfolio Behind the Paper blog post on our recent work on photoaffinity-based fragment libraries here: https://t.co/GVghXhMMt0

[BryanRoth @zenbrainest]

'These findings imply that vascular anatomy sets a resolution limit on functional imaging signals... individual blood vessels inaccurately report neuronal activity in their immediate vicinity ...'
https://t.co/xHP3iGKJr8

[András Tóth @AndrasDToth]

Our perspectives on the various aspects of bias in GPCR function, with a special focus on their relevance to the kidney, have been published in @NatRevNeph. https://t.co/knY2bAZKBE

[András Tóth @AndrasDToth]

Astonishingly, differences in beta-arrestin recruitment almost completely disappeared without endocytosis. Since beta-arrestins form stable interaction with AT1R, even at endosomes, we speculated that agonist-specific differences occur endosomally.

[Science Signaling @scisignal]

A new paper shows that the #endocytosis of #GPCRs such as AT1R can influence biased signaling through #BetaArrestin, suggesting the efficacy of beta-arrestin-binding ligands depends on spatial location as much as on receptor conformation. @semmelweishu https://t.co/ReFrZhsmNO

[Science Signaling @scisignal]

Research reveals how location within cells can influence the phenomenon of biased signaling, a Focus dissects recent research spotlighting a potential target for cognitive enhancement, and more in the new issue of #ScienceSignaling. https://t.co/kZX8b9FwAo

[Nikon Microscope Solutions @NikonInst]

Congratulations to @katonalab and colleagues on their new article! They combine #Electrophysiology and correlative #Confocal and #SuperResolution #Microscopy to identify and study single synapses, providing insights into retrograde cannabinoid signaling: https://t.co/xiy4s3xuFc

[Cell Reports @CellReports]

ArreSTick motif controls β-arrestin-binding stability and extends phosphorylation-dependent β-arrestin interactions to non-receptor proteins https://t.co/L39N56kZ3G

[Barna Dudok @BarnaDudok]

DSI is a form of synaptic plasticity mediated by endocannabinoids (eCBs). With @LinlinZFan, we demonstrated in vivo that place cell activity triggers eCB signals affecting GABAergic inputs; and that cannabinoid receptors modulate place cell tuning.
https://t.co/3Lbq50ggWu

[Arun K. Shukla @arshukla]

I had read a paper on GPCRs and arrestins in @jbiolchem several years ago and sent a congratulatory note to the authors. I met the 1st author in Budapest last week and he mentioned how motivating that email was to him and inspired him to continue in this field. #Win#For#Science.

[András Tóth @AndrasDToth]

A few years ago, I conducted an experiment with an endocytosis inhibitor that completely changed my understanding of signaling bias. We dove deeper into the spatiotemporal aspects of bias. See our @biorxiv preprint for more: https://t.co/C9d0U0n3rg #GPCR #signaling #pharmacology

[Bence Szalai @ben_szalai]

Excited to share our recent review in @FrontSystemsBio, which highlights the use of perturbation gene expression profiles to connect causal perturbations to gene expression changes for drug discovery applications. https://t.co/Rn09jUnMol

[RCNS MedChem Research Group @keserulab]

We congratulate our colleague, Péter Ábrányi-Balogh, for his recent achievements: in addition to being promoted to senior research fellow, Péter was recently awarded with the Zemplén Géza Prize for his work in organic and medicinal chemistry! 👏👏

[Bence Szalai @ben_szalai]

Can we identify common mechanisms behind antiviral drug effects by analysing drug and SARS-CoV-2 induced gene expression signatures? Our latest project, led by @BarsiSzilvia is now published in @PLOSCompBiol: https://t.co/290C0N74mh

[DrGPCR @DrGPCR]

Just in time before the holidays! Congrats @AndrasDToth for your presentation @DrGPCR Summit! Enjoy the goodies! #gpcr #drgpcr

[Nature Biotechnology @NatureBiotech]

A fluorescent sensor for spatiotemporally resolved imaging of endocannabinoid dynamics in vivo #PKU https://t.co/Mg9dDjUT3e

[Matt Hill @canna_brain]

The opening keynote session of the #CannabinoidGRC is in full steam, so great to see science in person @zenbrainest @HurdLab @katonalab

[Journals of The American Psychiatric Association @APAPubJournals]

A systematic review presents evidence that psychosocial interventions for adults with schizophrenia improve functional outcomes, quality of life, and core illness symptoms. Read more: https://t.co/rwn1AjY3au