Peter Tsvetkov

Biologist, scientist, proud father of three girls. Believe in Innovation, exploration and useless knowledge.

[Avner Schlessinger @SchlessingerLab]

New paper from the lab. Using AI-guided modeling and experiments, we identified a hidden allosteric pocket in the cancer kinase PKMYT1. Led by @NHerrington24 in collaboration with @LazarusLab https://t.co/TOVfd0tesd

[Sam Peng @CTSPeng]

Excited to share our work on ErbB receptors published today @CellCellPress! Using multicolor, photostable UCNPs, we perform long-term (>15 min) single-particle tracking of EGFR, HER2, and HER3, enabling direct visualization of dimerization in live cells. https://t.co/BZdJHyctl2

[BIDMC Cancer Center @BIDMC_CancerCtr]

Join us Wed. 2/25 (after the blizzard 🌨️) for our Cancer Research Institute seminar series w/ Sara Buhrlage, PhD @DanaFarber. Her lab specializes in deubiquitinase (DUB) biology, building a chemical biology platform to discover and validate DUB inhibitors as therapeutic targets.
#CancerResearch #CancerBiology

[Catalina Vasilescu, PhD @_CVasilescu]

A wonderful collection of literature from #week8 on #Mitochondria in #Health & #Disease! 📚

https://t.co/Ee9h6D11cS

@Bims_BiomedNews @gavinmcstay2 @mitoscientist @MitoAging @Mito_News

A [..] bifunctional enzyme mitigates redox imbalance and lipotoxicity
https://t.co/u23a0rZG87

[Nature Metabolism @NatMetabolism]

RESEARCH | @thebioKIMist @JasonRCantor et al. (@Morgridge_Inst):

Differential localization of the hexokinase HK1 isoform compared to the HK2 isoform, explains the conditional essentiality of HK2 in cancer cells cultured in physiologic media.

https://t.co/9DluG7FUQZ

[Barkai Lab @BarkaiLab]

(1/8) Still wondering how low complexity intrinsically disordered regions (IDRs) guide transcription factors (TFs) to bind in genomes? Previous studies on sequence grammars; our new @MolCell paper takes the next step: de novo design of functional TF IDRs!
https://t.co/qJugw2V3qE

[Shingo Kajimura Lab @KajimuraLab]

An excellent review of our recent paper on mitochondrial control of fuel switching – thank you!! The bottleneck of fat burning | Science https://t.co/Bi90o098nm

[Peter Tsvetkov @ptrtsvetkov]

Feels like my grant submissions 😂

[PUNS @ThePunnyWorld]

The bartender says, “We don’t serve time travelers in here.”

A time traveler walks into a bar.

[Jason R. Cantor @JasonRCantor]

For nearly a century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @NatMetabolism, led by @thebioKIMist! Leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q 🧵

[Alice Ting @aliceyting]

Can we design mutations that predictably bias proteins towards desired conformational states?

Today in @ScienceMagazine, we introduce Conformational Biasing (CB), a simple and scalable computational method that uses contrastive scoring by inverse folding models to identify conformation-biasing mutations.

https://t.co/lbWzHNdMRJ

[Peter Tsvetkov @ptrtsvetkov]

@VFCracan Great review !

[Peter Tsvetkov @ptrtsvetkov]

I love this concept. Although framed around #aging research, I think it can extend beyond that. We can use a synthetic approach, to study basic principles of cell biology and potentially mitigate human disease by engineering unique bacterial enzymes. https://t.co/6RTAhFbElS

[Peter Tsvetkov @ptrtsvetkov]

@VFCracan Agree ! We do the same for our favorite metabolic pathways . But hard to conceptualize how this could be streamlined as some enzymes need specific adaptation in human cells , and the readout for “screening” is not trivial . But definitely this is the way moving forward 🤓

[Peter Tsvetkov @ptrtsvetkov]

@silvirouskin @jeffreychsiao @DougWarui @JKwonBio @BookerMan_PSU @BIDMC_CancerCtr @BroadCancer Thanks Silvi 🙏

[Peter Tsvetkov @ptrtsvetkov]

Great way to end the year with our Deep Mutational Scanning of #FDX1 paper out, uncovering new mechanisms regulating #cuproptosis. Led by @jeffreychsiao and @DougWarui, and made possible by @JKwonBio and @BookerMan_PSU. @BIDMC_CancerCtr @BroadCancer https://t.co/Y3Vx0uz2P6

[Peter Tsvetkov @ptrtsvetkov]

New preprint out!
Deep Mutational Scanning of FDX1 Identifies Key Structural Determinants of Lipoylation and Cuproptosis
A quick twitorial 🧵https://t.co/lbHcRWG8Ir

[Peter Tsvetkov @ptrtsvetkov]

@DanLevy_BGU @jeffreychsiao @DougWarui @JKwonBio @BookerMan_PSU @BIDMC_CancerCtr @BroadCancer Thanks ! 🙏

[Peter Tsvetkov @ptrtsvetkov]

Join us on December 1, 3–4 pm, for another great set of talks on ferroptosis and apoptosis at the Boston Cell Death Initiative @BIDMC_CancerCtr.

[Kristopher Sarosiek @CellDeathLab]

➡️Join our upcoming BCDI discussions on the role of ferroptosis in autism led by Sundari Chetty @harvardstemcell and targeting apoptosis to overcome cancer chemoresistance led by Xingping Qin @HarvardChanSPH

Monday December 1st at 3PM @harvardmed Quad. https://t.co/uOJiL148QG

[Peter Tsvetkov @ptrtsvetkov]

Exciting work from @LevKats and team showing a direct link between heme homeostasis and #cuproptosis and how heme depletion can naturally induce cuproptosis, highlighting a targetable vulnerability in AML. Well done 👏👏.

[Cell @CellCellPress]

Now online! Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia https://t.co/GuCcuMHbkO

[Peter Tsvetkov @ptrtsvetkov]

Who decided rejection emails should hit at 4:59 PM on a Friday?
I just want a word. #ilovescience

[Peter Tsvetkov @ptrtsvetkov]

Inspiring talk by @KivancBirsoy today - great example of how functional genomics can uncover fundamental principles of cell metabolism, with a fascinating look at still-unresolved questions in mitochondrial redox regulation and the possible involvement of metals.

[BIDMC Cancer Center @BIDMC_CancerCtr]

Live from our #CancerResearch seminar series, @KivancBirsoy @RockefellerUniv speaks about understanding the role of compartmentalized metabolism in physiology and cancer. There’s a lot of interest in this subject, thanks to everyone who came, there isn’t a free seat left!