Dr. Reg So

organic chemistry, photo-triggered processes, DNA-templated synthesis

[Dr. Reg So @reg_so]

Happy to share that our seminal work on waixenicin A derivatization is now covered by a provisional patent:
“Waixenicin A Derivatives as Neuroprotective Agents against Hypoxic Ischemic Brain Injury Through TRPM7 Blockade.” @RomoGrp_Baylor

[Yulab @YulabJin]

Unlike functional group conversion, C-H bonds too far or too close are both hard to activate, but it is also the beauty if we can. Piperidine as the top pharmacophore, needs reaction to edit, but C-3 is too close, one bond extension works: Nat. Catal: https://t.co/NHrUU65h9m.

[Baran Lab @BaranLabReads]

Electrochemistry Goes Mainstream: Applications in Modern Total Synthesis, a review appearing today in @ChemRxiv :https://t.co/x4afIZCOLL

[J. Am. Chem. Soc. @J_A_C_S]

Versatile Synthesis of Cyclopentenones via Skeletal Editing of Phenols | Journal of the American Chemical Society https://t.co/ygEvznVSAk

[Yulab @YulabJin]

Sp3CHCoupling typically uses ArI and Ag, a huge drawback for process chemistry. With a long sigh, an unexpected Pd(II)/Pd(0)/Pd(II) cycle avoided both. Again and again, ligand design is the key for advancing CH activation: https://t.co/gFHEGPoH57

[Science Magazine @ScienceMagazine]

A vaccine that could provide protection against multiple pathogens would be invaluable, particularly during pandemics in which knowledge of the causative pathogen is limited.

In a new Science study, researchers found that a nasal vaccine designed to stimulate innate immune cells and T cells provided protection against both viral and bacterial lung infections in mice. https://t.co/SErpKv9RrB

[J. Am. Chem. Soc. @J_A_C_S]

Fe(porphyrin)-Catalyzed Alkene Epoxidation with NaOCl: A Practical Small- and Large-Scale Alternative to mCPBA | Journal of the American Chemical Society https://t.co/eo3z2DMm6k

[Krische Lab @KrischeLab]

Chiral-at-metal-and-ligand catalyst unlocks enantioselective alkynylation that is air/water tolerant and base-free. https://t.co/e29eIYpTVU

[Andrew Smith @ADS10_StAndrews]

Congratulations to Tengfei, Alister and Kevin - collaborative work with the Bühl group on the enantioselective dearomatizing [2,3]-Wittig rearrangement and divergent access to Sommelet-Hauser and [1,2]-rearrangement products is now online at @J_A_C_S .

https://t.co/8hA3JFzlz4

[Reggie Mills @reggiemills28]

In a tour de force of cobalt organometallics, PD Kavita @Kavita0809 has shed light on Csp2–Csp2 and Csp2–Csp3 cross-couplings, revealing weak field ancillary N,N ligands support diverging reactivities of high-spin and low-spin arylcobalt(II) catalysts
https://t.co/o0ZxmqmVh3

[KoenigChemistry @ChemistryKoenig]

Electrochemistry enables sustainable access to phosphorylated amine libraries from natural feedstocks, yielding bioisosteric analogues of amino acid derivatives.
Congrats to the team! @NayanSahaChem @OrgChemFront
https://t.co/YGEyPz1FQu

[J. Am. Chem. Soc. @J_A_C_S]

Stenhouse Zwitterion Photoswitches as Hydrogen-Bond Acceptors | Journal of the American Chemical Society https://t.co/W4KTExdaRY

[Chao Li Lab @LabChao]

Our latest work shows how modern total synthesis can enable therapeutically meaningful discovery, uncovering selective anti-C. difficile activity and toxin-protective effects of structurally complex polyether ionophores. Now available on ChemRxiv: https://t.co/iXiPUvBeja

[Michael Smietana @Smietana_M]

Excited to share our new paper in Nature Communications in collaboration with @OBasle !
We report the first artificial metallo-photoDNAzyme enabling highly enantioselective visible-light photochemistry via a DNA-embedded iridium photocatalyst.
https://t.co/CilVycEGeW

[Ohmiya Lab @OhmiyaLab]

Our work on deep-red/NIR light-driven Ni-catalyzed C(sp²)–C(sp³) cross-coupling has been published in ACS Catalysis (@ACSPublications). Congrats Kanji and Yusuke! https://t.co/pShlhMynY1

[Science Magazine @ScienceMagazine]

Researchers in Science report a kilogram-scale synthesis of enlicitide, a peptide drug for lowering low-density cholesterol that is in a Phase 3 clinical trial.

This new synthesis route leverages engineered enzymes and crystallization of key intermediates, substantially cutting down the number of reaction steps while improving yield. Learn more in a new #SciencePerspective: https://t.co/2g5nUA7d9G

[J. Am. Chem. Soc. @J_A_C_S]

Cobalt-Catalyzed Highly Regioselective Alkoxycarbonylation of Olefins Driven by Light | Journal of the American Chemical Society https://t.co/auqlYeYyCq

[PischelLab @LabPischel]

Our latest review titled "BASHY dyes as modular chromophores for multifaceted biorelevant applications: From imaging to photodynamic therapy" - now published in Chemical Communications https://t.co/tK5oJsvoAy @FcoGermanBldn @CIQSO_UHU @GoisLab @ChemCommun

[KoenigChemistry @ChemistryKoenig]

A mild strategy compatible with various solvents, air, and moisture @angew_chem
Congratulations to all involved!
Geminal Difunctionalization of Ketones via C─S Bond Insertion of Photogenerated Donor–Donor Diazo Compounds
https://t.co/yGa1DDOZ3F

[Yulab @YulabJin]

Methylene CH can now be coupled with Aryl CH. The scope is limited, but what new ligand can do is always a pleasant surprise: https://t.co/VvSwyYkMd1

[ACS Publications Bio & Med Chem Content @ACSBioMed]

X-Chem and CCG report DEL2PH4: a workflow that turns DEL data into predictive 3D pharmacophores, bridging DEL and medicinal chemistry to unlock actionable SAR for drug discovery. #ACSMedChemLett

https://t.co/SFl6XaNCDT