Rishabh

Rice with Rishabh! 🍚
PhD student@Ebitz lab, Université de Montréal 📌

[Ethan Lambeth @LambethEthan]

Two ant colonies have been fighting a war outside San Diego for decades.

~30M die a year. The front line is miles long.

[Simo Ryu @cloneofsimo]

It has to be some gods endgame plot that latest theoretical breakthrough on gradient descent and matrix multiplication came from
Gradient descent and matrix multiplication

[Saurav Das @SauravDassss]

🚨IMPORTANT NEWS🚨

Since Chief Election Commissioner Gyanesh Kumar is in the news, I have some very important but sad news to share about a Supreme Court judge.

Supreme Court judge Justice Satish Chandra Sharma. Just two months away from retirement.

If you remember, the Allahabad High Court had imposed a penalty on Medha Roopam, the DM of Noida and daughter of Gyanesh Kumar with a fine of five lakh rupees for irrationally issuing NSA order against a student Activist for Noida labour protest.

That order was challenged before the Supreme Court of India. Live Law, the news portal, reported that Gyanesh’s daughter’s case was listed before Justice Satish Chandra Sharma out of turn and in violation of the Supreme Court roster and rules and convention. The challenge ought to have gone before Justice Nagarathna’s bench, known to be an independent upright judge.

Two days back, when the matter was listed for hearing, Justice Sharma‘s bench switched off the audio of the Supreme Court proceeding, which is highly unusual and almost never done. ALARMING. There was no explanation from the judge’s side as to why this extraordinary favour was done for Gyanesh’s daughter.

In any case the fine and the adverse remarks of the Allahabad High Court were stayed by Justice Sharma immediately.

Same day, in another case related to Gyanesh Kumar—the constitutional challenge that was filed against the 2023 law on election commissioners of India was finally decided by a two judge bench of which Justice Sharma was a part of.

Under challenge was the appointments procedure where the leader of opposition today holds only an ornamental seat in the Three-member selection committee that selects Election commissioner of India. The other two are PM and his Cabinet Minister. Justice Sharma dissented which led to a split verdict and the case has now been sent before the Chief Justice of India for constituting a larger bench. This has delayed the case by years probably. This split verdict itself came after three years. This is how the Supreme Court refuses to hear most important cases that affect our lives and the country.

A separate blanket immunity granted to past and present election commissioners of India by Modi’s government is also pending for last 9 months before CJI Surya Kant. Today, the Chief Election Commissioner has been exposed for gross illegalities and for stealing votes and elections at the behest of powers that be. Any sane, sorted, neutral, just person can see that the selection process of ECIs is not independent and tilted in govt’s favour. But not Justice Sharma.

And here’s the big news: his son holds not one, not two, but four big, plum government counsel panels, including income, tax department, GST, customs, and excise, and a Madhya Pradesh government lawyer panel. I need not explain the great perks and influence that come along when you hold such plum government panels. Read my Justice Swarana Kanta Sharma report where I exposed the same thing.

I am withholding the name of the son for now.

The important question is: how can a judge be expected to do impartial and fair Justice in politically sensitive cases if his family members serve at the pleasure of the government? The judge is also retiring two months later, and several lawyers have informed me that there are vacancies in NCLAT and other search plum tribunals.

I’M SORRY TO SAY such a system of judiciary does not inspire confidence in its ability to do impartial justice. There is a reason why the ethics code for judges require them to maintain a sense of aloofness and not do anything which can harm the their image and that of the judiciary.

Both in Justice Swarna Kanta’s case and several other judges case, including that of the Supreme Court, it is TRAGIC to notice the complete capture of the institution of the Indian judiciary. Can the judiciary go on like this?

[Maitreyee Wairagkar @Maitreyee_W]

Excited to share that Brain2voice 2.0, a high-intelligibility, low-latency voice synthesis BCI, has been accepted to #NeurIPS2026! 🎉

Preprint: https://t.co/WH2JF5Fq3n

[Arthur Spirling @arthur_spirling]

Encouraging frontier labs to train on my research notes, just to set them back a few years. Doing what I can for AI safety

[Rishabh @rishabh9973]

This talks so much sense.

[Somi @somi_ai]

Derya Unutmaz asked GPT-6 Astra for a protein that doesn't exist in nature. Glowing jellyfish protein fused to an immune signaling molecule. It ran AlphaFold and handed back a 3D structure in about a minute.

Honestly, cool. But AlphaFold will give you a confident, beautiful structure whether or not the thing folds in a real cell. Someone still has to go make it and find out.

I'd bet wet lab queues get a lot longer this year.

[Rishabh @rishabh9973]

Would be even cooler if it was more like blue brain project.

[evnsnclr @evnsnclr]

I’ve successfully run the full retained MaleCNS v1.0 fruit fly connectome, all 166,700 neurons, inside Minecraft, with its simulated neural activity driving a fly’s movement.

V1 Currently in development. Built with the help of GPT-6 Astra.

Props to the @OpenAI team and @thsottiaux for this release. Code and mod coming soon!

[Dr. Swapneil Parikh @swapneilparikh]

Alright, time for a fact-check by a proud Indian doctor who studied peptides in MBBS and kept studying them afterwards.

The FDA is not “busy approving peptides.”

A US FDA advisory committee recommended SIX of seven unapproved peptides for possible inclusion on a compounding list. The recommendation is non-binding and is not FDA approval. So before lecturing Indian doctors about their “1998 textbooks,” perhaps learn what actually happened at the FDA. If you learn a little history about Vladimir Khavinson, maybe you won’t shit on 1998 textbooks so much.

You took BPC-157, TB-500, GHK-Cu, Semax and Epitalon and your back pain improved? Great. That is an anecdote. You have claimed a temporal association without even understanding causality. Next time you take Semax, see if the alleged cognitive enhancement can help you learn the difference between temporal association and causation.

Your digestion improved too? I don’t think so. You’re regurgitating too much BS to claim digestive health.

Your “biological age” came back 2.5 years younger? Now demonstrate that a 2.5-year movement in that assay represents a 2.5-year change in biological aging, a change in pace of aging, or even a clinically meaningful biological change. You can’t infer any of those things from the number alone.

You’re invoking Jennifer Aniston and Hailey Bieber while mocking doctors for wanting evidence? Celebrity endorsement is apparently your evidentiary hierarchy. Which celebrity did you consult for your shitty telehealth platform? Or did you consult Indian doctors?

You’re so scientifically unserious that you invoke celebrity endorsements while apparently being unable to conduct a basic literature review. Have some self-respect. At least bring animal data or a mechanistic argument.

Nobody is “denying an entire class of molecules.” Medicine uses peptides extensively. The scientific question is whether THESE molecules, at THESE doses, by THESE routes, for THESE indications, have evidence of efficacy and acceptable safety.

“Peptides clear out fast, therefore you can experiment fast” is pharmacology by slogan, and a remarkable display of scientific illiteracy. Plasma half-life does not determine the duration of every downstream biological effect, nor does rapid clearance magically eliminate immunogenicity, toxicity or other risks.

And “we need to cure aging” sounds impressive until someone asks you to operationalize it. What exactly are you curing? What endpoint are you modifying?
What validated measure of aging are you following? How will you distinguish modification of a risk factor, improvement in function, treatment of an age-related disease and actual modification of the biology of aging?

Caloric restriction where appropriate, resistance training, aerobic exercise, adequate sleep and aggressive management of cardiovascular and metabolic risk are considerably easier entry points into healthy longevity than peptides. They have the inconvenient advantage of substantial human evidence and, for several of them, hard clinical outcome data.

Run your N=1 peptide experiments. I strongly support your autonomy to do so. But an N=1 experiment does not become clinical evidence because you founded a shitty telehealth company, learned some longevity buzzwords and threw a peptide party.

You say no alcohol here but I bet you reconstitute your peptides in 0.9% Benzyl ALCOHOL. It’s literally an alcohol. And I bet there’s ETHANOL at your little party too. You don’t even understand basic chemistry and then say Indian doctors don’t understand peptides. You’re a joker.

Your origin story is boring. It’s a rerun of thousands of others just like you: intellectually lazy and pridefully overconfident.

Your startup, Zelta, is as unimaginative and uninnovative as you are. The only hack you should celebrate is that someone had the fiduciary irresponsibility to fund your POS startup.

[Rishabh @rishabh9973]

Indian medical commerce should focus on better use of AI (like discovering new enzymes, viruses, diagnosis) unlike these pseudoscience peddler @deepigoyal measuring whacky entropy of brain or this dude promoting consumption of unapproved peptides. 🫤

[TheLiverDoc™ @theliverdoc]

@sowmay_jain 🫶

[Sridhar Ramesh @RadishHarmers]

Jacobian conjecture 2: It works for everything except that particular counterexample.

[Rishabh @rishabh9973]

But ebola is also a peculiar virus with new arms coming out at each outbreak. Take utmost caution (although if it is the same strain as in Congo then it is not airborne.)

most likely the patient already had it before taking the flight and virus in its latent state.

[Prof. Devi Sridhar @devisridhar]

Reminder that Ebola is passed through bodily fluids- usually to someone caring or treating a patient in close proximity. It’s spread through blood, saliva, semen, vomit, urine, faeces. You’re unlikely to get it from being on the same plane, but best to get ahead and trace and monitor contacts.

[Poonam Agarwal @poonamjourno]

‘Tired of fighting alone’: Doctor, who campaigned against fake ORS, goes off Instagram
https://t.co/ETT0AFIJIy

[Rishabh @rishabh9973]

I have some big doubts about the controls and feasibility of eeg here. But it can also be an opportunity to dispel pseudo science beliefs with concrete evidence.

[Sandhya Ramesh @sandygrains]

There was a time the IITs were famous for scientific engineering and high-level research. How low they have fallen today. IIT Mandi, IIT Kanpur, and University of Virginia just concluded a special session on reincarnation and astrology. Absolute shame!!! https://t.co/Txvk9Vw9hR

[Rishabh @rishabh9973]

Rest in peace Dimitri Bertsekas . He was such a good author and teacher. I will miss more of his books but always remember him as a brilliant teacher.

[Yi Ma @YiMaTweets]

Professor Dimitri Bertsekas will be missed by many and many more to come… RIP.🙏🙏🙏

[Prof. Michael Lin @MichaelLinLab]

There is a big elephant in the room in experimental systems neuroscience:

Before many trainees can test a single hypothesis, they spend 1–3 years becoming expert mouse surgeons rather than scientists.

Here's my proposal for how we can waste less time and do more research🧵

[Benyamin Abramovich Krasa @BenyaminAK_BCI]

🧠🗣️ Ever stumbled over your words, realizing only after speaking them outloud? Your brain might not have followed the plan. New preprint on the neural ensemble organization of speech motor plans and what it means for speech BCIs https://t.co/f7zpqNDKSc 1/10

[Nature Rev Neurosci @NatRevNeurosci]

Large-scale electrophysiology at single-spike resolution — a Review by Joshua H. Siegle & Nicholas A. Steinmetz

https://t.co/LDnMNDCboO

[Rishabh @rishabh9973]

more I use claude more I want to do experimental neuroscience