Latest from the lab! Led by @XueningHe922, establishing a framework for interpretation of the motif syntax of regulatory elements and a quantitative model for TF cooperativity. Plenty of cool stuff revealed, including TF redundancy and synergy, and their regulatory roles!
Excited to share DeepCompARE + ISA - a lightweight deep learning model + efficient interpretation method, to uncover rules of TF cooperativity via genome-wide in silico motif ablations!
Preprint: https://t.co/e95WEt49Hv
Github: https://t.co/mIfrHKprBh
🚨Job alert! 🚨
We are hiring a computational postdoc or PhD student focusing on
- modeling gene regulation using single cell data
- investigating the mechanisms of regulatory genetic variants
PhD student: https://t.co/9JvmJrwnkf
Postdoc: https://t.co/K4JclsgALp
Check out our latest work, scE2G, for mapping the target genes of enhancers from single cell data! https://t.co/dz16ahux8O. See 🧵 below for highlights
Amazing work led by co-first authors @mayayayas and @613weilin in a great collaboration with @jengreitz 's lab
Excited to share our latest preprint on scE2G – a new model to link enhancers to target genes using single-cell data – with state-of-the-art performance across multiple perturbation benchmarks.
https://t.co/id1eCkQVdM
Read more below!
1/12
Happy to share our joint work with the Falsig Pedersen group on how the physical microenvironment can drive cells to acquire cancer hallmarks. https://t.co/LSHJ1lIZPz . In solid tumors, niches with low pH are common. We show that pancreatic cancer and normal organoids...(1/N)
Sooooo excited to share the first paper from the lab now online @NatureGenet 😀😀😀
Interested in MYC, transcriptional mechanisms and (breast) cancer? Check it out👉https://t.co/3FU5B2RNcO.
Short summary thread 👇
A true curiosity-driven journey, fulfilling one of my childhood dreams! The tail loss marks a pivotal evolutionary step towards humans and apes. But how did it happen? https://t.co/jTcOAH0Fcs @ItaiYanai@JefBoeke
7 days left to apply for our #postdoc position on RNA modifications at the University of Copenhagen!
If you’re interested in combining #CRISPR with #nanopore direct RNA sequencing to explore the role of #RNAmodifications in #RNAdegradation, apply here!
https://t.co/JbQNa10D4f
An encyclopedia of enhancer-gene regulatory interactions in the human genome
https://t.co/lxzN7cQTGA
Very proud—4 years in the making, huge team effort.
This is a paper where the author list cannot convey everyone's incredible contributions.
My holiday highlights below:
1/
“Transposable elements contribute to nearly 80% of human-specific candidate cis-regulatory elements in cortical cells” 🧠 …🤯 literally! Amazing dataset 🔥 Congrats to all involved!
https://t.co/75JfdawHMc
🧬Opening for a postdoc in my group @NCMMnews @UniOslo@UniOslo_MED@unioslo_mn to generate deep learning models to enhance JASPAR @jaspar_db & UniBind, boosting gene regulation research. Project in collaboration with @anshulkundaje, @WyWyWa.
Plz share
https://t.co/vXHWK4aDVd
Come and join us!
We are looking to recruit a Research Assistant/Technical Associate I to join our team Summer 2024.
This could be an ideal position for someone looking for 2 years of research experience before starting graduate school.
Apply: https://t.co/6nhNfbVTu4
Congratulations to all our students who have done an excellent work as part of our @HorizonEU network over the last 3 years. Our @EMBO workshop starting today is a great opportunity to add a new dimension to their scientific careers.
#EMBOenhanceropathies
@MSCActions
Two training sessions on communication, led by @AlberichJorda , kick off our final event this afternoon.
See our program
EVENT VI ▶️https://t.co/93xHhbE1fH
Learn more about @enhpathy_H2020 ▶️ https://t.co/qSRmZJ3cVb
@MSCActions
This will be my (academic) home during the fall. On a sabbatical at the Broad, kindly hosted by @kasper_lage and the @novonordiskfond center for genomic mechanisms of disease. Looking forward to lots of interactions and awesome science! Reach out if you want to meet up!