Johannesburg to St. Louis to Philadelphia
St. Olaf '13 | Jefferson MDPhD '21 | Penn Neurology '25
Neurology, epigenetics, bioinformatics, and board gamez.
A genomic test is the optimal way to rapidly diagnose central nervous system infections, 7-year performance data @UCSF in thousands of patients
for metagenomics next-gen sequencing https://t.co/frtkhX2dMk
@NatureMedicine @PBenoit93 @chiulab@UCSFMedicine
Ahmed et al. summarize putative mechanisms linking neuronal cholesterol with Alzheimer’s disease, and discuss current strategies to develop a brain cholesterol-modulating pharmacotherapy. https://t.co/7EOXt1PfQU
Spatial transcriptomic patterns underlying amyloid-β and tau pathology are associated with cognitive dysfunction in Alzheimer’s disease https://t.co/FVKmzeFAco
What do you do when a patient has simultaneous, potentially life threatening intracranial bleeding and a large pulmonary embolus? Excellent and nuanced discussion from @caseyalbin ⬇️
Patients with FTD often present with repetitive behaviours, including compulsivity, stereotypy, and hoarding. Restrepo-Martínez et al. review established definitions of repetitive behaviours and propose operational definitions applicable to FTD. https://t.co/3W7r8ehtPn
#AI is a winner at (the game of) diplomacy.
In a new Science study, researchers from @MetaAI describe CICERO, an artificial intelligence agent that has mastered the online board game of Diplomacy. Learn more: https://t.co/2yYKOaKFTY
Disease Reactivation After Cessation of Disease-Modifying Therapy in Patients With Relapsing-Remitting Multiple Sclerosis: https://t.co/TpWuZ2rRpk #NeuroTwitter#MS
A paper in @NatureNeuro presents an atlas of neurotransmitter receptor/transporter densities in the human cortex and shows that receptor achitecture reflects brain structure, function, dynamics, cognitive specialization and disease vulnerability. https://t.co/hQD7673W9S
A study in @SciReports finds that a deep learning method can identify which patients on Bi-Level Positive Airway Pressure are likely to fail with good discrimination, oftentimes days before they are intubated in usual practice. https://t.co/bwoDvVZNpz
A study in @NatureGenet examined the genome of 178,076 siblings to estimate the effects of genetics and environment on health and social outcomes. https://t.co/fobEOL5C2P
Steinkellner et al. report that dopaminergic neurons capable of co-releasing glutamate are more resilient to degeneration in animal models and in patients with Parkinson's disease, suggesting that a glutamatergic identity may be neuroprotective. https://t.co/buXNBaxUeN
A Review published in @NatureRevGenet discusses the diverse and multilayered mechanisms by which transgenerational epigenetic inheritance can occur in different species. https://t.co/PtEKjdxE5S
Use of an AI algorithm for interpretation of electrocardiograms in primary care practices increased the frequency at which impaired heart function was diagnosed during a clinical trial, according to a paper in @NatureMedicine. https://t.co/755AQmVaQK
DeJesus-Hernandez et al. use long-read targeted sequencing to investigate clinicopathological associations with the length of the expanded repeat in C9orf72-linked diseases. https://t.co/SHzI7wppP5
Stefani et al. show that RT-QuIC can detect α-synuclein in olfactory mucosa samples obtained by nasal swabs from patients with Parkinson’s disease, or isolated REM sleep behaviour disorder, with moderate sensitivity and high specificity versus controls. https://t.co/OsKB5wTvji