Danny Saban

Immunologist leveraging the eye to study #neuroimmunology #mucosalimmunology #immuneprivilege #macrophage

[Danny Saban @SabanLab]

So the question is not only: where do resident macrophages come from? It is also: when does self-maintenance become durable, and when does it fail to do so? That is the problem Establishment Kinetics is meant to solve. Full paper in Advances in Immunology https://t.co/JtcwezzZTB

[Duke Eye Center @dukeeyecenter]

In the latest issue of VISION magazine, we reflect on the impact of Edward Buckley, MD.

[Shiri Gur-Cohen 🟦 @ShiriGurCohen]

Incredible work and phenomenal imaging! 🤩 congratulations @erturklab and team!

[John Lukens @LukensJohnR]

Spatial proteomic analysis in human Alzheimer’s disease brains enables identification of microenvironment-dependent microglial cell states
@NatureNeuro
https://t.co/TKNLb8cv2i

[Duke Eye Center @dukeeyecenter]

We’re proud to share that W. Daniel Stamer, PhD, FARVO has been elected the next Executive Vice President of @ARVOinfo

Join us in congratulating Dr. Stamer on this outstanding achievement and his continued impact on advancing vision research.

https://t.co/Tlf2wTPLhJ

[The Colonna Lab @TheColonnaLab]

What defines human pDC diversity? Our newest work led by @UlezkoAlina in @ImmunityCP uncovers a complex landscape shaped by age and tissue niche, including a cycling pDC subset that declines with age but persists in the BM & expands in malignant BPDCN. https://t.co/O0UJ5O02sa

[Waggoner Lab @LabWaggoner]

Spatial proteomic mapping of the human and mouse retina using IBEX @JCI_insight @ucl
https://t.co/Ouxh62YCjF

[Miriam Merad, MD, PhD @MiriamMerad]

The proposed FY2027 budget includes a $5.8B (−12.3%) cut to the NIH. United for Medical Research calculated this could cost ~50,000 jobs and $11.6B in economic activity, with 26 states losing >$100M each. A tragedy for science, patients, and the economy. #NIH

[Duke Eye Center @dukeeyecenter]

We’re proud to share VISION 2026, highlighting the momentum and progress across the Duke Eye Center.

Read: https://t.co/BOZzUEbolN

[Hen Mazzig @HenMazzig]

Artist Noga Erez became the first Israeli artist to perform at Coachella 🇮🇱

At the end of her set, she said she was deeply grateful to be there, adding that it took strength she didn’t know she had to get here.

She also said she loves making music and that she does it to bring people together.

What a show!

[Danny Saban @SabanLab]

Neutralizing antibodies are not the whole story. Very cool!

[Iannacone Lab @iannaconelab]

Neutralizing antibodies are not the whole story. In @NatRevImmunol, we highlight an alternative mode of protection: T cells can eliminate infection at its earliest stage, before it becomes detectable. We term this “abortive infection”
https://t.co/omOjotwLxZ
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[Danny Saban @SabanLab]

@jonykipnis חג שמח יוני!

[Danny Saban @SabanLab]

@SEStorck Agreed

[Danny Saban @SabanLab]

We argue for sunsetting the M1/M2 dichotomy in eye macrophage research, supported by single cell RNA-seq data demonstrating a complexity that does not conform to this binary framework. 50 day free link
https://t.co/PRmnHwo6vh

[Filiano Lab @FilianoLab]

Was a blast guest editing this special issue for @J_Immunol . Check out these amazing reviews on brain border sites.

https://t.co/JqFw5TGHFH

[Danny Saban @SabanLab]

50 day free link
https://t.co/uFPhkHJxt5

[Danny Saban @SabanLab]

Resident tissue #macrophages (RTM) are now recognized as integral regulators of tissue physiology, not transient immune sentinels. But one fundamental question remains unresolved: why do some populations achieve lifelong self-maintenance, while others are progressively replaced under steady-state conditions? 🧵

[Danny Saban @SabanLab]

So the question is not only: where do resident macrophages come from? It is also: when does self-maintenance become durable, and when does it fail to do so? That is the problem Establishment Kinetics is meant to solve. Full paper in Advances in Immunology https://t.co/JtcwezzZTB

[Danny Saban @SabanLab]

@r_sankowski @JustinPerryPhD https://t.co/uFPhkHJxt5 - does this work?

[Danny Saban @SabanLab]

@JustinPerryPhD We focused on normal physiological conditions as a starting point , but totally agree with you

[Waggoner Lab @LabWaggoner]

Macrophage lineage and spatial compartmentalization govern tumor immunity @NatImmunol @claudjak @soubhik1992 @RawatKSM @XinLi0419 @AishwaryaDighal @dartmouth
https://t.co/TF52PtAzmo

[Danny Saban @SabanLab]

this work would not have been possible without my incredible co-authors: Eden Jacob, @sfortma2 , Kyoung Woo Kim, @voigt_drew , Maria Grant, Dan Stamer, Katy Liu, Jeremy Lavine, and Peter Wieghofer.