Sam Lord

Research Associate | Proteomics Core Facility | CRUK

[Sam Lord @SamLord98]

Excited to share our latest review in the Journal of Cachexia, Sarcopenia and Muscle @JCSM_cachexia. Here we show how mass spectrometry can be used to profile ubiquitin signalling in skeletal muscle. Great team effort with @HarveyEJohnston and @SamantLab

https://t.co/Bux0pmImGf

[Nature Methods @naturemethods]

News & Views from @DemichevLab and @LrSinn: Advances in single-cell proteomics allow quantification of half of the expressed proteome in an individual cell.

https://t.co/FQKjmDddAY

[Sam Lord @SamLord98]

Really grateful to have been given the opportunity to present at another @physoc conference. Great to catch up with colleagues and meet new researchers in the muscle field. Nice bonus to have been chosen for the ECR oral communication award 😀

[The Physiological Society @PhySoc]

🎉 Many congratulations to the #EarlyCareerResearchers competition winners!

The winners & runners ups for the Flash Talks & Oral Communications were announced at our #MuscleLoss meeting @UniofExeter.

Well done to all the awardees and presenters, see details below 🧵 1/3

[Archie Belfield @BelfieldArchie]

Sarcopenia prevalence using handgrip strength or chair stand performance in adults living with type 2 diabetes mellitus...

https://t.co/GydvmisrXb

[Sam Lord @SamLord98]

Really enjoyed learning more about Genomics, Proteomics and Biodata. Always a bonus to showcase some of our work on the ageing muscle proteome and engage in some great discussions #FOG2024

[Sam Lord @SamLord98]

Happy to see my first PhD project now published! Here we studied the mechanisms of ubiquitylation utilised by a family of muscle-specific enzymes known as MuRF E3 ligases.

https://t.co/SuCvCoQ07g

[Lamming Lab @LammingLab]

Really cool new paper "The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency" at @Cell_Metabolism ! An entirely new way in which mTOR senses AA deficiency https://t.co/SH9ZteL5In Thanks @pak_heidi for pointing out this one.

[Babraham Institute @BabrahamInst]

We’re excited to plant the seed of a UK-wide network bringing together researchers at all levels with an interest in #proteostasis #ProteinQualityControl. 1/4

https://t.co/51rCPAGTIW

[Kylie Walters (she/her) @kyliejwalters]

With a fixed typo, I re-invite you to come chat Ub & Targeted Protein Degradation with our welcoming community at the @FASEBorg #UBPSRC where full days of exciting science with joyful interactions will be capped by nightly fireworks over the natural wonder of Niagara Falls.

[Sam Lord @SamLord98]

Great to have been part of this larger project! I’m now very intrigued about the Leloir pathway and studying it further with our new cell line 🧫

[Gareth Wallis @gareth_wallis]

Lots of questions here around if the circulating galactose is/was used for glycogen synthesis. We don't have the answers. Our exploratory analysis by @alex_seabright @SamLord98 and @RitaCivil saw human skeletal muscle expresses Leloir pathway enzymes at gene and protein level 6/7

[Sam Lord @SamLord98]

Global analysis of ubiquitylation site occupancy, revealing how this effects ubiquitin turnover rate (DUBs) and signalling (proteasomal or non-proteasomal).

https://t.co/qazuyTOXuO

[Rita Civil @RitaCivil]

New paper out! Bone🦴 markers responses to running 🏃‍♂️

@Sale_ExNut, @ElliottSale, Phil Atherton, Ian Varley, @Liv65761161, @PaulSwinton9, and @eimeardol

https://t.co/gmDZxZKnnI

[Jatin Burniston @ExercProteomics]

Some snapshots from our poster session today #HMAC2023 ⁦@ARThealthyaging⁩ ⁦@LJMUSportSci⁩ ⁦@physoc⁩ ⁦@BiochemSoc⁩

[Pastel BioScience @PastelBio]

One-Pot Analytical Pipeline for Efficient and Sensitive Proteomic Analysis of Extracellular Vesicles | https://t.co/fp5euQDwQo #proteomics

[biorxiv_physio @biorxiv_physio]

Beyond Myosin Heavy Chains: Ribosomal Specialization Drives Human Skeletal Muscle Fiber Heterogeneity https://t.co/jvU8YvRUwm #biorxiv_physio

[Inside Exercise @inside_exercise]

Now online. I really liked this chat!:

Muscle atrophy with aging mainly protein breakdown

New thinking on muscle nuclei/satellite cells

Drugs not as good as exercise for healthspan

Thanks (no Twitter) Benjamin!

Spotify (https://t.co/QZQSi4ZmaR), Apple Podcasts, YouTube etc

[Sam Lord @SamLord98]

Great time competing in my first Racketlon competition, certainly more to come…

[UK Racketlon @UKracketlon]

Well done to Jordan Marcus (Men's B) and Saul Abbiss (Men's C) who both won their first UK Racketlon titles at the 2023 York Open 👏

[Sam Lord @SamLord98]

Glad you enjoyed it 😊. Thanks @physoc for the opportunity to present this work, the feedback has been great. #Physiology2023

[Sam Lord @SamLord98]

Really interesting panel discussion about the process of publishing. Great to hear honest views from peer reviewers and editors #Physiology2023

[Andrew Mackenzie @awmackenzie]

🥳Final countdown! @physoc annual conference starts Monday morning. Looking forward to joining hundreds of physiologists from 40 countries in Harrogate to discuss the latest science & forge new collaborations. See you there!

https://t.co/VVS7Mt7MUU