sanatabish

[World Tumor Registry @WTumorRegistry]

☀️ WTR Case Series | August Edition ☀️

🔬 Case 9: Poorly Differentiated Thyroid Carcinoma – Childhood & Adolescence

Key Features:
• Solid growth pattern
• >5 mitoses/2 mm²
🧬 DICER1 (E1813D)

👉 Explore the full case: https://t.co/xcB5dc8wuC

#WorldTumorRegistry #Pathology

[Katrina Collins, MD || Pathologist @katcollmd]

#slidearchiveseries perinephric myxoid pseudotumor of fat #gupath #pathtwitter #pathoutpic

🔬 fat with lymphoplasmacytic infiltrate and myxoid change
📍non-neoplastic renal disease and transplant
⚠️ mimics WDLPS and IgG4-related sclerosing disease

🔗 https://t.co/0P5xiAh0bu

[Matthew Zaba @mattzaba1]

🟪Uterine myxoid leiomyosarcoma🟪

Macroscopic:
➡️WHO: myxoid tumours may be gelatinous and friable
➡️May look deceptively circumscribed. Still sample the interface

Diagnostic criteria 🔬
WHO Female Genital 5e, essential criteria box, myxoid:
One or more of:
➡️Moderate to severe cytological atypia (2+/3+)
➡️Tumour cell necrosis
➡️> 0.4 mitoses/mm² (equating to > 1 mitosis/10 HPF of 0.55 mm diameter and 0.24 mm² area)
➡️Infiltrative borders / irregular margins

For contrast, conventional spindle LMS (same box): two or more of marked atypia (2+/3+), tumour cell necrosis, or ≥ 4 mitoses/mm² (equating to ≥ 10 mitoses/10 HPF of 0.55 mm diameter). That mitotic number does not apply here.

Myxoid leiomyoma (WHO leiomyoma box):
➡️Circumscribed, hypocellular and myxoid, lacking cytological atypia or mitoses

STUMP (WHO): exceeds the leiomyoma box, below the LMS box.

Tips:
☑️Extensive sampling may be required to find the diagnostic areas (WHO)
☑️Confirm myxoid stroma (Alcian blue–positive acid mucin), not hydropic oedema (WHO leiomyoma chapter)
☑️Desmin, h-caldesmon, and SMA may be weak or patchy in myxoid tumours (WHO)
☑️CD10 is often positive (WHO). It does not separate this from a stromal tumour
☑️If it sits between the two boxes, that is STUMP. WHO: try to land leiomyoma or LMS first, with generous sampling

#PathTwitter

[A. Sarah Erem @CakePath]

Warty Dyskeratoma Rocks:
🕳️ Crater / cup-shaped lesion = Architecture clue → start thinking WD immediately
🔓 Suprabasal acantholysis →Loss of cohesion (Darier-like)
🧬 Corps ronds + grains = Dyskeratosis → confirms pattern
🌿 Villous projections 🧱Sealing feature → helpful, almost specific
#dermpath #dermatology #dermatologia #dermtwitter #pathology #pathologists #pathTwitter

[Benard Solomon @BenServiceNotes]

Experts Argue Over Cytology Images_89
Many
ASC_H
Some
CIS
Few
HSIL
Me
HSIL
What's Your Opinion?

[Elizabeth Montgomery, MD @LizMontgomeryMD]

A technically terrific endoscopic submucosal dissection (ESD) specimen with a gastric intramucosal adenocarcinoma (T1a) that has pyloric/cardiac gland differentiation. @xiahepublishing @UMiamiPathology @ModernPathology @science_press

[Janira Navarro @Janiranavarro]

WHAT'S NEW IN GASTROESOPHAGEAL TUMORS (WHO 6TH EDITION 2026)
Epidermoid metaplasia was added as a precursor lesion (new to WHO)

Dr. Montgomery PathCast GIPS
https://t.co/cLz2yW20FH #PathX #pathology

[Gerônimo Jr. @GeronimoJrLapac]

Uterine Smooth Muscle Tumors -Types necrosis. Left: tumor cell necrosis ; right:Infarct-type. N= necrosis : H =Hyali

[Scholarship for PhD @ScholarshipfPhd]

A great research paper is more than good results.

It tells a clear story:

1. Introduction → Why the study matters
2. Methods → How the study was conducted
3. Results → What was found
4. Discussion → What the findings mean

Strong research isn't just about discovering something new. It's about communicating it clearly so others can understand, evaluate, and build on your work.

[Felipe Templo Jr. ,MD, MBA 🕊 @thejourneymate]

Approach to Soft Tissue Tumors:
A Stepwise Diagnostic Algorithm 🔬

[Researchable @Researchable_SA]

طريقة كتابة وتصميم وعرض الـ Research Poster بشكل احترافي 🎓📌

هذا الدليل مفيد جدًا للمبتدئين، خصوصًا إذا كانت هذه أول مشاركة لك في مؤتمر علمي أو أول مرة تعرض فيها بحثك 👇🏼

[Ting Zhao, MD @TingZhaoPathdoc]

70s F, renal mass. Diagnosis?
#PathX #PathTwitter
@MGBpathology

[GU Pathology Society (GUPS) @GU_Path_Society]

Dr. Epstein sharing case examples of medicolegal cases & lessons to learn! #GUPath

[C. Christofer Juhlin @DrJuhlin]

SYP+ adenocarcinoma has been previously reported, and occasionally these cases display focal CgA+, but this didn't feel right. So I threw in the 2nd gen NE marker INSM1...

[C. Christofer Juhlin @DrJuhlin]

To be able to discern between these entities, allow me to introduce this fabulous algorithm from Dr Rindi and colleagues in @EndoPath!

https://t.co/sq8jZcxeI5

[Tim Bracey @drtimbracey]

Incidental polyp in the terminal ileum of a colon cancer right hemicolectomy. IHC negative apart from patchy CD34. This is a benign calcifying fibrous tumour. Can be found anywhere in the GI tract and do not have any syndromic associations (IgG4 IHC was less than 40%) #GIpath

[Charlie Herndon @DrCycloPath]

#CytoQuiz #Thoracic 🫁

A) Adenoid cystic carcinoma
B) Typical carcinoid
C) Adenocarcinoma
D) Basaloid squamous cell carcinoma

#Pathology #Cytology
Clue in caption 🧐

[Charlie Herndon @DrCycloPath]

#CytoQuiz 🧐🔬
A) Solitary Fibrous Tumor
B) Inflammatory Myofibroblastic Tumor
C) Schwannoma
D) Dermatofibrosarcoma Protuberans
#Pathology #Cytology
Clue in caption 🧐

[Janira Navarro @Janiranavarro]

How to differentiate between adenoid cystic carcinoma and basaloid squamous cell carcinoma?

p40 stains basal/myoepithelial cells only in ACC and is diffuse in SCC.
Pitfall ⚠️: SOX10 and MYB IHC can be positive in both.

Dr. Nishino - 2025 Diagnostic Pathologic Update #USCAP #pathology #PathX