Antonio

[Antonio @secantmodulus]

@tmodarressi @Drlipid Please tell me more

[Antonio @secantmodulus]

@Drlipid How does lerodalcibep differ from the other pcsk9s? Would make for an interesting video 😊

[Antonio @secantmodulus]

@Drlipid Also do you think this could give us some insight on how obicetrapib could be priced (pending approval, of course)?

[Antonio @secantmodulus]

@SeanMcGuireMD @Lpa_Doc @derlinge @UCSDCardiology If one does not carry the rs3798220 variant and still has very high lpa, would ASA therapy still help in a primary setting? Thank you!

[Antonio @secantmodulus]

@hsbhatia @AlexRazavi @UCSDCardiology @UCSDCardFellows @FamilyHeartFdn @nationallipid @ASPCardio What about those who do not have the rs3798220-c mutation but still have very high serum levels of lp(a)? Does
ASA offer the same level of RR?

[Antonio @secantmodulus]

@MohammedAlo Apart from lipid management, do you also recommend a baby aspirin? Thank you !

[Antonio @secantmodulus]

@DrDerekConnolly @DrScottMurray @ZSiudak @DrKoltowski @CotsCardiology @LondonCardiacCT @NickCurzen @mirvatalasnag @ColinBerryMD @HRahbi @danmckenzie73 @BudoffMd Why so? Even in the context of Lp(a)?

[Antonio @secantmodulus]

@DrScottMurray @DrDerekConnolly @ZSiudak @DrKoltowski @CotsCardiology @LondonCardiacCT @NickCurzen @mirvatalasnag @ColinBerryMD @HRahbi @danmckenzie73 @BudoffMd If intolerant to Aspirin, could clopidogrel be an option?

[Antonio @secantmodulus]

@Drlipid Do you find this result somewhat surprising? A particle that is supposedly 6x more atherogenic than ldl is almost eliminated from plasma, and this has no effect on MACE..

[Antonio @secantmodulus]

@doctorvasan @AaronGuidice99 @drpablocorral Thank you for your reply. What is btd?

[Antonio @secantmodulus]

@doctorvasan @AaronGuidice99 @drpablocorral Wouldn’t this also depend on whether NAMS actually apply for early approval? Do you have a source for whether they have done this/intend to do this?

[Antonio @secantmodulus]

@im_dori2 Where abouts in Europe? Even if you pay out of pocket?

[Antonio @secantmodulus]

@WilliamsCatcher @doctorvasan @Drlipid @DLipid0607 Thank you Barbara. If I may ask, on what selection criteria were you accepted into the trial? I mean, there is an ldl-c cutoff and not Lp(a). Were you refered by your doctor?

[Antonio @secantmodulus]

@WilliamsCatcher @Drlipid @doctorvasan What was your starting ldl-c during the trial ? Would you be comfortable sharing your numbers? Thank you!

[Antonio @secantmodulus]

@Drlipid @MohammedAlo @AhmedYAzzam Is one CVOT trial enough for approval from a primary prevention point of view?

[Antonio @secantmodulus]

@doctorvasan Newb here. Is CVOT data absolutely necessary for regulatory submission/approval?

[Antonio @secantmodulus]

@JohnKastelein @Lpa_Doc Lipid novice here. Why would alcohol increase HDL-c?

[Antonio @secantmodulus]

@Drlipid @nationallipid @society_eas @escardio @atherosociety @FamilyHeartFdn @fhpatienteurope A very useful and informative video on the upcoming ASO and siRNA drugs. Thank you doc!