Piali Sengupta

Brandeis Bio/Neuro. We study multiple aspects of sensory biology. Mostly in worms. Lab appears to be powered by vast quantities of junk food. Opinions mine.

[Piali Sengupta @SenguptaLab]

Multiple postdocs out to academic/industry jobs + 2 grant NOAs in = open postdoc position.

Worms are great to work with, sensory biology is an endlessly fascinating topic, and we are a group of good humans. Please email if interested!

[Piali Sengupta @SenguptaLab]

Opening for a lab manager/Res Asst! This is a great position if you want more research experience (& perhaps co-author a paper or two!) before heading to grad school. We are a sociable, supportive, inclusive, and dynamic group - come join us.
https://t.co/gxC0OOoFLJ

[Piali Sengupta @SenguptaLab]

🎉👏🏽Check out the brand new lab of our star (and much missed) ex-postdoc @nathanCSharris!!! He has a super cool planned research program and is going to be an awesome mentor. Go Nathan!!

[Piali Sengupta @SenguptaLab]

@rburdine1 That would be a dream come true! Come do a sabbatical!

[Piali Sengupta @SenguptaLab]

Multiple postdocs out to academic/industry jobs + 2 grant NOAs in = open postdoc position.

Worms are great to work with, sensory biology is an endlessly fascinating topic, and we are a group of good humans. Please email if interested!

[Piali Sengupta @SenguptaLab]

@MarinaP63 @KiaNobre @aa_fenton @c_eroglu @ArlottaLab @americanacad See you there this afternoon!

[Piali Sengupta @SenguptaLab]

@Roy_Lab_Thinks Mine too. Had no idea of the history - (wrongly) thought it had Indian origins. Fascinating.

[Semil Choksi @semilc]

We thought there wasn't much new to learn about the cell cycle. Turns out we were wrong! Our paper (out today @Nature) identifies a novel alternative cell cycle that regulates differentiation, not cell division. https://t.co/ayDhJtKK6U. 1/10

[Piali Sengupta @SenguptaLab]

@McIntyre_Lab Glad to see you still ♥️ cilia!

[Piali Sengupta @SenguptaLab]

Alison used a ts kinesin allele that she generated (thanks to Chlamy ts screens!) to show that
a) IFT is not necessary to maintain cilia of the AWA olfactory neurons, &
b) even w/o cilia, AWA can respond to some food-related odorants. 2/6

[Piali Sengupta @SenguptaLab]

@MahjoubLab My deepest condolences Moe. So sorry to hear this.

[Piali Sengupta @SenguptaLab]

TL;DR: IFT & cilia structure shape responses to stimuli sensed by a single neuron type in different & unexpected ways. Alison untangles this complexity by conditionally manipulating IFT & measuring response dynamics to individual chemicals. Questions/comments welcome! 6/6

[Piali Sengupta @SenguptaLab]

What about sensory response adaptation? By acute manipulation of IFT, Alison shows that IFT is needed for diacetyl but not pyrazine adaptation, likely by trafficking the diacetyl but not the pyrazine receptor. 5/6

[Piali Sengupta @SenguptaLab]

🎉New lab preprint! 🔥🔥work by super postdoc @alison_marie1.
C. elegans sensory neurons have gorgeous #cilia at their dendrite ends. We’ve always thought that a) no cilia = no sensory responses, & b) no IFT = no cilia. Punchline is we thought wrong. Read on for more. 1/6

[bioRxiv @biorxivpreprint]

Differential modulation of sensory response dynamics by cilia structure and intraflagellar transport within and across chemosensory neurons https://t.co/VDRQ4LQyOI #bioRxiv

[Piali Sengupta @SenguptaLab]

@Mill_lab 🥳!!

[Piali Sengupta @SenguptaLab]

Woo-hoo! Go invertebrates and small (not necessarily 'simple' circuits and of course, go @betenoire1 and Gerry Rubin!

[HHMI @hhmi_science]

Congratulations to @HHMIJanelia's Gerry Rubin & @RockefellerUniv’s Cori Bargmann (@betenoire1), recipients of the 2024 Gruber Neuroscience Prize for their pioneering work on the circuitry of behavior & development of new tools for neuroscience research.

🔗https://t.co/Lt9xq37U8I

[Piali Sengupta @SenguptaLab]

Popping back on here to thank my mentors, colleagues and friends @BrandeisScience & elsewhere, my funders, & my very patient family. Most importantly, thank you to all the students & postdocs who chose to science along with me. And of course 🙏🏽 to our beloved worms!

[American Academy of Arts & Sciences @americanacad]

Announcing our new members! The Academy is honoring excellence in an array of disciplines and professions, and inviting these new members to join our work to advance the common good. The first members were elected in 1781. Learn who was elected in 2024: https://t.co/TtvnZxeJXk

[Piali Sengupta @SenguptaLab]

@MadS100tist @ReiterLab Thank you!