Shivani Sachdev, PhD

👩‍🔬 Assistant Professor @ACTREC_TMC | Postdoctoral Fellow @NIDDKgov @NIH | Pharmacology & Chemical Biology | Editor @BrJPharmacol | Views my own

[Cancer Research Institute - ACTREC @CRI_ACTREC]

PhD August 2026 intake:
2nd round of in person interviews for PhD kick off from today. Best wishes to all the candidates appearing for the interviews this week. Pls read up on the labs & projects you are interested in!
@biopatrika @ACTREC_TMC

[Rohan Khadilkar @RohanKhadilkarr]

ACTREC Life Sciences PhD Intake
August 2026 batch
List for 2nd round announced
In person interview from June 1 to June 5, 2026! Pls plan your travel
@biopatrika

[CSIR-IGIB @IGIBSocial]

Terrific science, engaging discussions, and wonderful camaraderie — the IGIB-ACTREC Conclave beautifully captured the spirit of collaborative science. Conversations with like-minded people are always a pleasure.

@IGIBSocial
@singhajay518
@foldingINvivo
@arpan_parichha @shruthy_suresh @BhallaSherry @Ankesh1406

[Shivani Sachdev, PhD @ShivDoesScience]

4/ Leaving with a heavy heart, but excited to step into a new role — stay tuned 🚀

[Shivani Sachdev, PhD @ShivDoesScience]

1/ A bittersweet goodbye to the #Cheloha lab at the @NIDDKgov🥹 Five years into this postdoc, and I am walking away with so much more than I ever expected 😇

[Shivani Sachdev, PhD @ShivDoesScience]

3/ Grateful for an extremely supportive mentor, Ross Cheloha, and for everyone in the lab who made this time so special 🥳

[Cornelius Gati @CorneliusGati]

Excited to share @Nature: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein (wt) structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation. 🧵
https://t.co/E2fZXw2Pom

[Ah-Ram Kim @ahramkim1128]

Evaluation of Alphafold modeling for elucidation of nanobody-peptide epitope interactions https://t.co/fkBO7lOvct

[Shivani Sachdev, PhD @ShivDoesScience]

Here to put the “boo” in boo-orthogonal click chemistry—and maybe pull a few tricks (or treats)! 🎃🧪

Happy #Halloween from the lab! #SpookyScience #LabHalloween

[BowTiedBiotech 🧪🔬🧬 @BowTiedBiotech]

Degrader Tac-opedia

🔘PROTAC: E3 ligase-targeted proteolysis
🔘DUBTAC: Deubiquitinase stabilization
🔘LYTAC: Lysosome-targeted degradation
🔘Trivalent PROTAC: Multivalent E3 ligase
🔘AUTAC: Autophagy-targeted degradation
🔘RIBOTAC: RNA-targeted degradation
🔘RNA-PROTAC: RNA-binding E3 ligase
🔘BioPROTAC: Antibody/peptide proteolysis
🔘Aptamer-PROTAC: Aptamer proteolysis
🔘GlueTAC: Lysosomal traffic & degradation
🔘Peptide-PROTAC: Peptide-based E3 ligase
🔘NanoTAC: Nanobody-based E3 ligase

H/T: Donggeon Kim on the HR app!

[Andrew Akbashev @Andrew_Akbashev]

Nobel Prize is NOT about h-index or citations.
It is about the emergence of big new fields.

So many posts discuss Nobel awardees.
And so many misunderstand the Nobel Prize.

📍 A bit of clarification from my side:

1⃣ Nobel Prize is NOT about how useful your work is.

It’s about how useful it WILL BE.
Science is not about real-world impact.
It is about new knowledge, new understanding.
It’s about nucleating new ways of thinking.

Applications can come decades after the discovery.

2⃣ Nobel Prize is NOT about just doing risky research.

Many of us take on risky projects. But most stay as niche studies that could have been done by others.

It’s about doing what others are AFRAID to do.
It's about looking like a reckless scientist.
It’s about succeeding where others have failed (despite numerous attempts).

3⃣ Nobel Prize is NOT about a small study.

It’s about nucleating a BIG research direction.
It’s about "OMG, I didn't know it's even possible!"

Yes, sometimes it takes decades to recognize a scientist. But in many cases, the prize was given to those who published the "nucleating studies" and pushed hard to grow the new field.

4⃣ Nobel Prize NOT about a lot of citations.

Metrics doesn't matter.
Forget this "Stanford top-2% ranking".
Your peers' opinion is what really matters.

Are you recognized by your peers SO MUCH that they want to see you as a Nobel Laureate?

Do they see you as someone who created their field and made their research possible?

Do they see you as their thought leader?

▫️

My HUGE congratulations to all Laureates.

AI has changed science a lot.

Those who made it possible deserve this recognition.

#science #AcademicChatter

[NIH @NIH]

Congratulations to the 2024 #NobelPrize in Chemistry winners, Drs. David Baker, Demis Hassabis and John M. Jumper! Dr. Baker’s #NIH-supported work at @UWMedicine building new kinds of proteins is an incredible example of the value of taxpayer investment in biomedical research.

[David K Smith @professor_dave]

So she was first author on his key paper - in fact she's on most of his key papers, yet she didn't get the Nobel Prize, in spite of the fact they could have given 3 awards, not just 2. Explain to me how STEM is not institutionally sexist.

[Sudarshan Rajagopal @SudarRajagopal]

Excited to share new work from our lab led by Uyen Pham – “Location-biased β-arrestin conformations direct GPCR signaling.” We demonstrate that b-arrestins display distinct conformations in different subcellular locations in regulating ERK MAP kinases. https://t.co/kf2dRBNkBt

[Nature Communications @NatureComms]

Cryo-EM structure of GPR179, a GPCR crucial for visual signalin, reveals how its dimer architecture fits curved membranes . @KLabGPCR

https://t.co/EUUUOBPWeh

[ECI GPCR symposium @cool7TMs]

👩‍🔬 👨‍🔬 Join us for the 4th Transatlantic ECI GPCR Symposium this Thursday and Friday!
Come for science done by ECIs, ask about current & future trends in lunch sessions, hear career panel discussion, and network! Last hours for registration: https://t.co/HHCAx1avGh

[Ben Myers Lab @Myers_lab]

Now published in @PLOSBiology: How GRK kinases control #GPCR signaling in the #Hedgehog transduction cascade in primary #cilia.

https://t.co/BRi7tOMZ4A