Sibin Stephen

℞ medical scientist | psychedelic researcher | perpetual learner

[Sibin Stephen @sibinRx]

Unconditional love is an oxymoron

[Sibin Stephen @sibinRx]

Aliens - A Sibin Perspective https://t.co/UmalnyJIk0

[Jesse Michels @AlchemyAmerican]

In light of today’s revelations around Apollo 17 interacting with UFOs, here’s Japanese NASA historian Takano Jousen: He was close with astronaut Eugene Cernan who told him during the mission, aliens gave him a message never to return to the moon - that’s why they stopped at 17

[Bryan Johnson @bryan_johnson]

5-MeO-DMT gave me a single idea that won't leave.

Our minds are not naturally capable of understanding the preciousness of our existence.

Not "life is precious" as printed on a poster. It's something much more specific. That the hardware we're running, human consciousness, cannot render the full resolution of what it means to be here. Like a 480p screen trying to display an 8K image. The information is there but the display can't hold it.

It's been 3 weeks and I still feel childlike and fresh. My mind feels free of the accumulated barnacle. My dreams are alive.

The brain data is now coming in and it matches my reported subjective experiences. I'm excited to share it with you.

But the data doesn't complete the picture. The feeling is that I found a home I didn't know I was looking for and I don't have a biomarker for that.

[Sibin Stephen @sibinRx]

@0x_ultra What was your workflow to make this? This is awesome btw

[Bryan Johnson @bryan_johnson]

I did a 40 hr and then a 70 hr social media fast.
I’ve come to believe that social media is pollution. 

Not a vice or guilty pleasure.
It’s closer to water toxins, air pollution and microplastics.

Social media has been on my mind because I can feel how bad it is for me. For my health and agency. I am a professional rejuvenation athlete. For five years, I’ve engineered my life around biological renewal and the elimination of decay. After hundreds of experiments across food, sleep, exercise, therapies, and toxins, I’ve developed both data and intuition about what strengthens or degrades my system.

I can viscerally feel that social media is bad for me.  It erodes my autonomy and increases cognitive entropy.
Like other toxins, it accumulates. You can’t unsee or unfeel what you’ve consumed. It settles into mental tissue like heavy metals, producing chronic low-grade inflammation.  Evidence suggests even after you stop scrolling, attentional fragmentation and emotional priming persist. Your thoughts begin to mirror the algorithm’s incentives. Independent cognition quietly erodes and you don’t notice the loss.

Time away and getting lost in deep focus is the only remedy.

When something erodes your agency, the rational response is elimination. The problem is, elimination isn’t realistic. “Just put the phone down” is as practical as telling someone in 19th century London to stop breathing coal smoke.

You need to know what’s happening in the world, be in touch with your friends and be part of the tribe.

That necessity is what allows companies to harvest your emotions, intellect and time for their profit. You are their raw material they exploit. Then in an ironic twist, the system gets you to exploit yourself by engineering an environment where it takes more effort to stop than to continue scrolling.  Pollution exposure by default.

What specifically makes social media toxic is that value and poison are inseparable by design.  You go to hear from friends and you leave an hour later absorbed in outrage that serves no biological interest of yours. The water is real. The lead is in the pipes.

The performance metrics (likes, views, etc.) bleed you of independent thought. They create quantified social proof, triggering ancient hierarchy reflexes. You no longer evaluate signal from noise; the engagement metrics do it for you.

Like all toxins, the damage is cumulative. We live inside the exposure long enough that it feels normal.  The 40 and 70 hour social media fasts did that for me. Gave me just enough separation to feel and diagnose the poison. The obviousness of it feels like when I went to India and saw their humanitarian crisis of air pollution which no one sees anymore.

So what do we do?

Neither platforms nor individuals are likely to change on their own. AI may be the countermeasure. An AI layer between you and the feed. Filtering rage, removing vanity metrics and translating sensationalism into calm, factual language. Preserving signal and eliminating noise.

I want social media to become a longevity intervention, not a longevity threat. I never want to see the raw feed. I want an AI agent to read it for me, strip the engagement metrics that hijack my judgment, filter the rage, and return only what I actually came for.

Every generation faces its pollutants. When cholera spread through London's water, the answer wasn't telling people to drink less. It was building filtration. The same logic applies here. Best next move is to design the filter to avoid being the raw material.

[Andreas Storm @avstorm]

Love these new Anthropic videos

[Elica Le Bon الیکا‌ ل بن @elicalebon]

What’s going on in Iran, how did we get here, and why you should pay attention.
In collaboration with @TheFP

[Eric Weinstein @ericweinstein]

I cannot wait to visit Tehran.

Persia is of our world’s greatest cultures. Iran has been almost half a century under this oppressive theocracy.

Wishing you all every success. Good luck out there.

I do not understand the lack of our coverage here. But we still hear you.

LFG.

[Nicolas Rouleau @DrNRouleau]

My essay on the brain as a electromagnetic receiver of consciousness, entitled "An Immortal Stream of Consciousness" was one of the winners of the Bigelow Institute for Consciousness Studies (BICS) @BigelowInst Essay Competition. Is survival possible?

Read it here: https://t.co/GgzPVNHpsO

[Bryan Johnson @bryan_johnson]

I think magic mushrooms are a longevity therapy.

After seeing the data from two doses, psilocybin offers unique longevity effects that complement the best performing therapies I’ve done to date including sauna, hyperbaric oxygen therapy, sleep, nutrition and exercise.

This was the most quantified psychedelic experiment ever done.

It's noteworthy that even though many of my biomarkers are already in the 99th percentile optimal, psilocybin still showed multi-system improvements. Something other therapies have not been able to accomplish.

Of course, my data will need to be replicated and the magnitude and duration of benefits needs further assessment.

Here is what we learned:

0. We observed broad benefits across mental, hormonal, metabolic, and anti-inflammatory systems. Since these are the primary drivers of biological aging, this multi-system signal offers a compelling case for longevity potential.

1. Psilocybin may be a metabolic reset button for the brain. We expected brain changes, but not a potential metabolic breakthrough. My blood sugar control improved from the top 2% of the population to 0.2%, better than 99.75% of 18-25 year olds.

2. Psilocybin reduced my inflammation (hsCRP) to below detectable levels one week post dose.

3. Psilocybin calmed my body and mind.  Lower cortisol, and an inhibited HPA-axis in the days following the dose. Both my cortisol and DHEA (another product of the adrenal cortex) dropped 42% and 45% respectively, indicating an overall adrenal reset associated with rest and recovery.

4. Psilocybin increased brain plasticity, desynchronized default networks, resulting in enhanced creativity, playfulness, and openness, with reduced mental rigidity.

5. A second psilocybin dose built on the first and pushed sensory integration even further, increasing primary sensory-motor integration beyond the peak of the first dose.

6. Psilocybin induced an intense blend of joy, deep insight, and a subtle hint of melancholy,  also detectable by thermal biometrics.

We had two significant firsts in this experiment:

0. First documented human CGM-based observation of improved post-psilocybin glucose control.

1. First-ever thermal profile of an intense psilocybin dose.

Pending data:
+ Telomere length and relative telomerase activity (telomere regeneration capacity).

+ Epigenetic measurements

+ Microbiome

Experiment details

Here are more details about my two magic mushrooms trips, doses, and the results of my measurements up to date.

I had two doses of dried and powdered Psilocybe Cubensis (Variety  B+) mushrooms, three weeks apart.

First dose Nov 9th: 4.67g (24.98 mg psilocybin and 3.5 mg psilocin). Setting: relatively private, only with @_katetolo and the accompanying guide.

Second dose Nov 30th: 5.35 g (28 mg psilocybin and 4 mg psilocin). Setting: relatively open, with friends and family joining virtually, and live streaming.

I dissolved the first dose in orange juice but used lemon juice for the second, for the following reasons:

+ Lemon is more sour, which delays the conversion to psilocin and breakdown in solution, thus preserving more total psilocybin to be activated to psilocin after ingestion.

+ Lemon juice has, on average, 70% less sugar and 45% less calories, making it less disruptive to my otherwise faster state throughout the journey, and leading to a much lower glucose peak.

Rewired brain connectivity

Kernel Flow measurements after the first dose showed shifts in my brain connectivity mirroring my subjective experience, and the mapping of 5-HT2A receptors.

These included the inhibition of my default networks and command centers including prefrontal context and a shift towards increased functional connectivity and hyperintegration between primary motor, sensory, auditory, and speech integration. This coincided with an entropic brain pattern, more open, flexible, exploratory, and creative, indicating a shift from aged and rigid to open youthful brain state.

The baseline measurement before the 2nd dose indicated a strong lasting effect from the first dose 3 weeks earlier, post-peak measurement after the 2nd dose indicated an additive effect of the 2nd dose, with a brain entropic and increased primary sensory-motor integration beyond the peak of the first dose. Most notable was the increased intensity of integration and activation of the auditory, speech, and language networks, coinciding with the second dose being joined by family, friends, where I enjoyed expressing and describing my feelings.

Face and body thermal biometrics

We produced the first ever face and upper body thermal map of a magic mushroom journey.

A core temperature increase of 1.5–2°F suggests an intense psychedelic experience, likely due to a large psilocybin dose (28 mg psilocybin, 32 mg combined psychoactive content).

Heat was redistributed to the core, consistent with 5HT2A–mediated autonomic activation, which can include increased sympathetic tone, lasting through the peak and early post-peak of the experience.

Facial and body thermal shifts indicate a potential blend of intense joy, insight, and subtle sadness or melancholy.

First documented human CGM-based observation of improved post-psilocybin glucose control

Psilocybin appears to have triggered a previously unknown metabolic reset in my brain, an unexpected breakthrough.  Comparing the 3-day periods before and after the psilocybin dose:

My blood glucose control dramatically improved, moving from the top 2% to the top 0.2% of the entire population, including healthy 18-25 year olds.

+ 8% reduction in mean blood glucose, reaching 80.84 mg/dL, a new personal best.

+ 11% reduction in fluctuation, indicating smoother glucose peaks and improved control.

+ This single session reduced my estimated HbA1c 0.3 6.8% from 4.7% to 4.4%, (a relative reduction of 6.8%).

+ Durability: The positive effect was still as strong on Day 3 post-dose as it was on Day 1.

Note: A long trip to China on Day 4 interrupted this streak. We plan to explore the full durability of this effect with the next dose.

This matters because we treat diabetes and metabolic dysfunction with chronic daily medication (Metformin, Insulin, GLP-1s). This data suggests that a neuroplastic event might have downstream effects on the liver and pancreas that mimic or exceed these drugs.

Systemic inflammation was below detectable levels

Five days after the first dose, my hsCRP dropped to an undetectable level (below 0.15 mg/dL), representing a 35-100% decrease from the pre-dose level of 0.23 mg/dL.

Three days post-second dose, hsCRP was barely detectable at 0.18 mg/dL, which is still a 22% drop from the initial baseline.

Tumor necrosis factor-alpha (TNF-alpha) remained unchanged between baseline and post-second dose. It was not measured after the first dose.

For the next dose, we will measure a wider panel of inflammatory markers, including IL-6 and IL-10, and cover several time points post-dose.

High cortisol at Peak, low cortisol and stress the following week

Cortisol spiked at the peak of the acute phase, followed by a decline in morning cortisol levels and HPA-axis inhibition, consistent with a relaxed "after-glow" phase in the week following the trip.

My cortisol spiked to 3x morning spike levels four hours after taking the mushroom dose. Levels returned to normal nightly baseline before bedtime.

Five days post-dose, my morning cortisol levels had dropped by 42%, and DHEA-S (a marker of adrenal activity) also dropped by 45%, aligning with inhibited HPA-axis and adrenal activity.

Estradiol levels increased by 200%, consistent with preliminary published evidence that peripheral 5HT2A activation increases cortisol by driving aromatase expression.

[Chris Ramsay @chrisramsay52]

A conspiracy theory that’s so crazy it just might be brilliant!

The theory goes like this: Spielberg has been chosen to deliver the next phase of disclosure. Not a leak in the traditional sense, but a carefully constructed big reveal.

What if Spielberg has been granted unprecedented access to real UAP footage or better yet, an actual UFO?

No better way to get disclosure then by the very means which have conditioned us to believe in them in the first place. The silver screen.

Imagine watching the opening credits to see these words:

“This film features an actual UFO”

It instantly becomes the highest grossing film of all time and Americans get to serve disclosure while we eat our butter popcorn.

I wouldn’t be mad.

Here are a few interesting facts: multiple congress people have shared the new Title change from “The Dish” to “Disclosure” with some pretty cryptic tweets. (See below)

Also, they’re filming in New Jersey… could explain the drone situation somehow..

OR

More likely, This is another way to control the narrative.. Good luck searching “UFO Disclosure” after this movie hits the theatres…

I don’t know. Fun theory for sure. How would you react?

[eigenron @eigenron]

One of the best things I’ve heard @naval say and you’ve probably never heard this so I’ll just drop it here. Ties to the theory of analogy and natural philosophy.

[Jesse Michels @AlchemyAmerican]

This will change the world

[Bryan Johnson @bryan_johnson]

Doing magic mushrooms this Sunday.

Protocol
+ dose: 5 grams
+ frequency: 1x/mo for 3 mo
+ objective: exploring longevity effects

Measurement
+ 249 independent biomarkers
+ 29 vials of blood
+ brain scans
+ urine, stool, saliva, fertility
+ multi-omics profiling (DNA, epigenetics, metabolism, hormones, microbiome, proteins, cognition)

Cardiovascular
+ LDL-C
+ HDL-C
+ Triglycerides
+ Total cholesterol
+ Apolipoprotein B
+ Apolipoprotein A-1
+ Lipoprotein(a)
+ LDL-P
+ HDL-P
+ Small LDL-P
+ LDL size
+ Large VLDL-P
+ Large HDL-P
+ VLDL size
+ HDL size
+ LP-IR score
+ Oxidized LDL
+ Lp-PLA2 activity
+ Myeloperoxidase (MPO)
+ Homocysteine
+ VEGF

Hematology
+ WBC
+ RBC
+ Hemoglobin
+ Hematocrit
+ MCV
+ MCH
+ MCHC
+ RDW
+ Platelets
+ Neutrophils
+ Lymphocytes
+ Monocytes
+ Eosinophils
+ Basophils
+ Immature granulocytes
+ Erythropoietin (EPO)
+ ABO/Rh typing

Hormonal
+ Thyroid panel with TSH
+ Free T4
+ Testosterone
+ Dihydrotestosterone (DHT)
+ 5α-DHT
+ Prolactin
+ Estradiol
+ LH
+ FSH
+ Estrone (E1)
+ Estriol (E3)
+ Androstenedione
+ Androsterone
+ 5β-Androstanediol
+ Etiocholanolone
+ Cortisol
+ Cortisone
+ DHEA
+ DHEA-S
+ Pregnenolone
+ IGF-1
+ Melatonin (6-hydroxymelatonin sulfate)

Metabolic
+ Glucose
+ Insulin
+ Hemoglobin A1c
+ α-Hydroxybutyrate
+ β-Hydroxybutyrate
+ Uric acid

Kidney
+ BUN
+ Creatinine
+ eGFR
+ BUN/Creatinine ratio
+ Cystatin C
+ Urinalysis (specific gravity, pH, color, appearance, leukocyte esterase, protein, glucose, ketones, occult blood, bilirubin, urobilinogen, nitrite, WBC [hpf], RBC [hpf], epithelial cells, casts, bacteria)
+ Albumin/Creatinine ratio

Pancreatic
+ Total protein
+ Albumin
+ Globulin
+ Total bilirubin
+ Alkaline phosphatase
+ AST
+ ALT
+ GGT
+ Amylase
+ Lipase

Minerals
+ Sodium
+ Potassium
+ Chloride
+ CO₂ (bicarbonate)
+ Calcium
+ Magnesium
+ Iron
+ TIBC
+ UIBC
+ Iron saturation
+ Ferritin
+ Zinc

Vitamins
+ Vitamin B12
+ 25-hydroxy Vitamin D
+ Coenzyme Q10
+ α-Tocopherol
+ β-Carotene
+ Glutathione
+ Total glutathione

Amino Acids
+ Cysteine
+ Methionine
+ Taurine
+ Glycine
+ Serine
+ Threonine
+ Alanine
+ Valine
+ Leucine
+ Isoleucine
+ Phenylalanine
+ Tyrosine
+ Tryptophan

Inflammation
+ Interleukin-6 (IL-6)
+ Interleukin-10 (IL-10)
+ Tumor Necrosis Factor-α (TNF-α)
+ Rheumatoid factor (RF)
+ ANA by IFA
+ Calprotectin (GI inflammation),
+ Secretory IgA (mucosal immunity)

Neurology
+ P-tau217
+ Epinephrine metabolites (metanephrine, normetanephrine)
+ Homovanillate (HVA)
+ Vanilmandelate (VMA)
+ 5-Hydroxyindoleacetate (5-HIAA)

Toxicology
+ Lead
+ Lithium

Urology
+ PSA total

Fertility
+ Total Motile Count
+ Sample Volume
+ Concentration
+ Motility
+ Morphology
+ Count

Metabolomics
+ Citrate
+ cis-Aconitate
+ Isocitrate
+ α-Ketoglutarate
+ Succinate
+ Fumarate
+ Malate
+ Pyruvate
+ Lactate
+ 2-Hydroxyglutarate,
+ Hydroxymethylglutarate,
+ 3-Methylglutaconate,
+ 2-Methylsuccinate
+ Formiminoglutamate (FIGLU),
+ Methylmalonate (MMA),
+ Xanthurenate
+ Kynurenate,
+ Quinolinic acid
+ Glucarate,
+ 8-Hydroxy-2′-deoxyguanosine (8-OHdG),
+ Pyroglutamate
+ 3-Hydroxyphenylacetate,
+ 4-Hydroxyphenylacetate,
+ 2-Hydroxyphenylacetic acid
+ 4-Cresol,
+ p-Hydroxybenzoate,
+ Benzoate,
+ Hippurate/Hippuric acid
+ Phenylacetate/Phenylacetic acid,
+ Indoleacetate/Indoleacetic acid
+ Arabinose,
+ Citramalic acid,
+ α-Hydroxyisobutyric acid

Microbiome
+ Bacteroides fragilis
+ Bacteroides vulgatus
+ Faecalibacterium prausnitzii
+ Akkermansia muciniphila
+ Roseburia spp.
+ Eubacterium rectale
+ Lactobacillus spp.
+ Bifidobacterium spp.
+ Escherichia coli
+ Clostridium difficile
+ Enterococcus faecalis
+ Candida albicans
+ Saccharomyces boulardii
+ Prevotella copri
+ Ruminococcus spp.
+ Methanobrevibacter smithii
+ Blautia spp.
+ Proteobacteria spp.
+ Firmicutes/Bacteroidetes ratio
+ Beta-glucuronidase
+ Butyrate
+ Propionate
+ Acetate

Aging & Epigenetics
+ Telomere length
+ Relative telomerase activity
+ DNA methylation age
+ DNA methylation levels at CpG sites associated with biological aging
+ Glucocorticoid receptor methylation (NR3C1)
+ SIRT1 methylation
+ MTOR methylation
+ Oxidative stress response genes (NFE2L2 promoter methylation)

Cognitive
+ Brain age score
+ Functional connectivity strength
+ Global connectivity index
+ Hemodynamic response amplitude
+ Hemodynamic response latency
+ Resting-state oxygenated hemoglobin (HbO) concentration
+ Resting-state deoxygenated hemoglobin (HbR) concentration
+ Total hemoglobin (HbT) concentration
+ Oxygen saturation (O₂Sat)
+ Cerebral blood volume (CBV)
+ Cerebral blood flow (CBF)
+ Neurovascular coupling index
+ Prefrontal cortex oxygenation
+ Parietal cortex oxygenation
+ Temporal cortex oxygenation
+ Occipital cortex oxygenation
+ Task-evoked hemodynamic response (HbO/HbR)
+ Temporal autocorrelation of hemodynamics
+ Functional brain network modularity
+ Inter-regional coherence
+ Brain lateralization index
+ Oscillatory power (slow cortical fluctuations)
+ Phase synchronization index
+ Mean reaction time (during cognitive tasks)
+ Reaction time variability
+ Heart-rate variability (HRV)
+ Resting heart rate

[American Alchemy @AmericanALCHMY]

An Alien Explains RELIGION To Man Hired By NSA To Speak To Aliens👇

[Miyra ﾒ𝟶 @ST4RG1RL4ABEL]

@MementoMoriXO Until I Bleed Out needs its credits

[Sibin Stephen @sibinRx]

Your aura is the
subtitle to your speech.

People read it even if they don’t know the language.

[Sibin Stephen @sibinRx]

“I think, therefore I am” assumed that thinking proves existence.

But what if a machine “thinks” without
existing as a subject?
AI shows us that thinking alone doesn’t imply being.

There must be a witness of thought — a presence that experiences it.

Otherwise, we have syntax without soul.