Si Fang

Senior Research Associate in Genetic Epidemiology & Causal Inference @MRC_IEU @BristolUni

[Si Fang @sifang1678]

I'm glad to announce that our polygenic score-metabolite atlas has been published on @eLife 🥳 This atlas contains associations between 125 PGS for complex traits and 249 NMR-derived metabolic traits from up to 83,004 individuals in the UK Biobank. https://t.co/4U5iYUGLmu

[Alice Carter @alicerosecarter]

There's been a lot of discussion recently about the misuse of MR, except the proliferation of incorrectly drawing your assumptions doesn't seem to stem from the recent explosion in papers. Rather, many high impact papers seminal to the field feature an "incorrect" arrow

a 🧵

[Marie Sadler @smarie_smarie]

Can we use biobank #EHRs to study the genetics of drug efficacy? 💊🧬
How to best model drug response and longitudinal biomarker progression in an unbiased manner? 📊
Do #PRS predict treatment outcomes?
Check out our new preprint https://t.co/Ki326tUn7t and the thread 🧵 below👇

[george davey smith @mendel_random]

I'm talking on "Mendelian randomization: what it was, what it is, and what it should become", in person at Sir Ambrose Fleming Lecture Theatre @ucl London, 25th April 3.30-6pm (with reception) or online (you can drink during it), MC'd by @AdamRutherford https://t.co/r8c16dbCqG

[Louise AC Millard @louise_millard]

Devastated I won't get to celebrate its anniversary each year (as I of course do for all my papers) ...

Our paper evaluating a global randomisation test for MR is now published in EJE –

https://t.co/aMMw7bpyW0

Thanks to @mendel_random and Kate Tilling

[george davey smith @mendel_random]

Yes indeed if there is nothing beyond the mechanical analysis - no triangulation in other words. For reasons to give to editors see https://t.co/Mchjef6XvL and https://t.co/6jSFEy3RRT and https://t.co/K1kUwFCNhV

[Golam Khandaker @golam_khandaker]

🔥 Do immune pathways causally affect psychiatric conditions? 🔥 Could they be new treatment targets?

Check out our most extensive proteo-genomic study to date of 735 immune related proteins & 7 conditions (SCZ, BPD, MDD, ANX, ADHD, Autism, Alzheimers).

https://t.co/yXdQBWueaQ

[Brenda Cabrera Mendoza @brendacabreram]

Very proud of our latest study, where we explored the impact of assortative mating, participation bias and socioeconomic status on the genetic risk of mental health traits. Check it out! 😊 https://t.co/yVKHuIKWqU

[Liza Darrous @LizaMGD]

Check it out 🧵👇! Our PWC-MR approach aims to tackle the some of the sources of bias that affect MR causal estimation: heterogenous causal effects & confounding. https://t.co/DmAluiCViO
Often studied separately, PWC-MR has shown that classifying instruments into clusters...(1/n)

[george davey smith @mendel_random]

What could be more thrilling than 3 days in ever-sunny Bristol debating the future of Mendelian randomization 19-21st June 2024? The 6th International MR conference, in the year MR gets its key to the door - but where will that door lead to? https://t.co/GnSBgXdNOb

[george davey smith @mendel_random]

Next @mrc_ieu webinar 3rd Nov 1pm UK time with @minouye271 on "Systems genomics for population health: From risk prediction to aetiology", in person and online https://t.co/wCXoOIFwWA

[Si Fang @sifang1678]

@AndrewHaoyu @nilanjan10c @XihongLin @JiananZhan @Jin_10ustc @JingningZhang35 Awesome work! Congratulations 🥳 Thank you for your detailed post and for sharing the datasets.

[george davey smith @mendel_random]

Looking forward to visiting sunny Exeter to talk on “Noodles, No Nulls and Numb Skulls: Threats to the future of Mendelian Randomisation” on 21st September at 11.00am (UK time). Also available online for those not lucky enough to live in sunny Exeter
https://t.co/axHl9s64Sz

[Zoltán Kutalik @zkutalik]

It's a pleasure to let you know that within the @DEMONNetworkUK we are organising a Mendelian Randomisation Symposium at the @turinginst. Invited speakers include @stevesphd, Kate Tilling and @jack_bowdenjack ! Abstract submissions are open until 30 Sep: https://t.co/XLQBp0G53l

[Alex Bick @AlexBickMDPhD]

Academics outside the US can now apply to access @AllofUsResearch. Please spread the word!
https://t.co/JnzPRyEpep

cc: @dgmacarthur @ceclindgren @timfrayling @minouye271 @nicolesoranzo @GLettre @samrip @ShaiCarmi @jgustavsmith @andganna @PaulLacaze @drjamesware @nickywhiffin

[Yi Liu @YiLiu6240]

A fully funded PhD opportunity in @mrc_ieu working with me, Zahraa Abdallah, @tomrgaunt, and supervisors from @Roche on automating literature mining and triangulation with AI and knowledge graphs https://t.co/O7oW9qpms0

[george davey smith @mendel_random]

Fantastic PhD opportunity on testing out the potential contribution of automated AI in triangulation with Yi Lui, Tom Gaunt et al @mrc_ieu https://t.co/VcFQW2Lxu8

[Verena Zuber @VerenaZuber]

Our multi-response Mendelian randomization MR2 model for the analysis of multiple related outcomes
→ To account for information shared between outcomes
→ To define shared causes of disease
is out @AJHGNews
https://t.co/iHSJWyBpmu
For a 🧵 please check
https://t.co/mZc2sZiWUt

[Si Fang @sifang1678]

Congratulations @QianYang_UOB 🥳

[The Neonatal Society @NeonatalSociety]

Kicking off the afternoon session of day 2 @NeonatalSociety summer meeting is our guest lecturer and Young Investigator Prize winner @QianYang_UOB presenting her work on effects of chronotype and sleep patterns on pregnancy and perinatal outcomes. #neoEBM #neoTwitter #perinatal

[Flo Martin @_flomartin]

Another exciting addition to our public engagement webinar on July 11th - @mrc_ieu's very own @eimear_foley1 to talk about her engagement & content curation work @Mental_Elf 🧠

Sign up using the link below - this is not one to miss! 👇

[george davey smith @mendel_random]

So this is happening tomorrow at 3pm in Boston, followed by what I've been told will be a champagne reception (tho' I fear warm Budweiser), in person @broadinstitute ground floor auditorium (no need to book - just turn up) & online (eg 8pm UK time) https://t.co/tE3Zh4Pf3h