Soumitra Pal

PostDoc at NCBI. Bioinformatics, Applied Algorithms. Prev: PostDoc@UConn, PhD@IIT Bombay.

[Soumitra Pal @soumitrakp]

Honored to receive the Richard Newton Lolley Memorial Travel Grant at the ARVO Annual Meeting in Seattle! Thank you @ARVOinfo for this incredible opportunity to connect with fellow researchers & advance vision science. More about the grant: link #ARVO2024 #Research #VisionScience

[Soumitra Pal @soumitrakp]

@elonmusk @aelluswamy Could Tesla add a “record macro” feature for regular trips? Let me drive from home to office once, save my route and driving preferences, then have FSD repeat the trip—always obeying traffic rules and adapting to traffic and road conditions.

[Soumitra Pal @soumitrakp]

Why revisit it now?
• MicroPublications make valuable results citable
• Open data, PubMed indexed
• Might spark someone’s next project
@AsifaAkhtar1,@ErcanLab,@XistHarvard,@NBrockdorff,@PlathLab,@CRougeulle,@PageLabXY,@rafaelgalupa
#Drosophila #DosageCompensation #OpenScience

[Soumitra Pal @soumitrakp]

(1/6) Different organisms solve sex chromosome imbalance in different ways.
• Humans: females dial down one X
• Drosophila: males turn up their single X
Same goal—balanced gene expression.
🧬 #XChromosome

[Soumitra Pal @soumitrakp]

(5/6) Patterns emerged 👀
• Male reproductive cells → lower compensation
• Neural cells → higher compensation
Known regulators (RoX1 & RoX2) were involved—but didn’t explain everything.
More biology to uncover 🔍

[Soumitra Pal @soumitrakp]

Using FlyCellAtlas+experiments, we reveal how organs scale via cell size/number diffs: bigger female flight muscles from more myoblasts, larger hearts from bigger cardiomyocytes & fat body tweaks. Allometric Framework for sex diffs in growth! #Drosophila #SSD #Allometry #Preprint

[Soumitra Pal @soumitrakp]

𝗛𝗮𝘃𝗲 𝘆𝗼𝘂 𝗲𝘃𝗲𝗿 𝘄𝗼𝗻𝗱𝗲𝗿𝗲𝗱 𝗵𝗼𝘄 𝗺𝗮𝗹𝗲𝘀 𝗶𝗻 𝘀𝗼𝗺𝗲 𝘀𝗽𝗲𝗰𝗶𝗲𝘀 𝗹𝗶𝗸𝗲 𝗵𝘂𝗺𝗮𝗻 𝗮𝗿𝗲 𝗯𝗶𝗴𝗴𝗲𝗿 𝘁𝗵𝗮𝗻 𝗳𝗲𝗺𝗮𝗹𝗲𝘀 𝗲𝘃𝗲𝗻 𝘄𝗵𝗲𝗻 𝘄𝗲 𝗲𝘅𝗰𝗹𝘂𝗱𝗲 𝘁𝗵𝗲 𝘀𝗲𝘅-𝘀𝗽𝗲𝗰𝗶𝗳𝗶𝗰 𝗼𝗿𝗴𝗮𝗻𝘀?

[Soumitra Pal @soumitrakp]

Excited to share our new preprint on bioRxiv: "Cell type specific allometry controls sex-differences in Drosophila body size"! https://t.co/YDSbwIwggN

[Soumitra Pal @soumitrakp]

Great job!
It’s a #Bestseller

[Sunayna Pal @sunayna_pal]

Please #welcome my #firstpost about #newbook #WashyWashybook
Discover the joy of clean hands with #WashyWashy"! This delightful #book turns #handwashing into a fun, empowering experience for #kids and parents alike.
Ideal for #parents, #teachers, and #caregivers

[Eytan Ruppin, MD, PhD @EytanRuppin]

How can tumors evolve by non-genetic mechanisms? It turns out adaptive expression patterns may also drive tumor evolution! Check out our melanoma evolution model @CellSystemsCP study in collab with M.G. Hirsch and Teresa Przytycka (@NLM_NIH, @NIH). https://t.co/CmviGm9OlV

[NEI @NatEyeInstitute]

(3/4)

More poster and paper presentations for tomorrow's schedule at #ARVO2024!

@soumitrakp

[Michael F. Chiang, MD @NEIDirector]

In just 12 days, at #ARVO2024 @NatEyeInstitute will have a big presence!

This will include updates, funding sessions, chances to meet program officers, presentations from our intramural research program, and more. @ARVOinfo

Here’s a summary: https://t.co/dcyfqkUk4u

[ARVO @ARVOinfo]

Save the date for the Friedenwald Award Lecture on May 6 (#ARVO2024, Seattle). Join Anand Swaroop, PhD, FARVO (@NatEyeInstitute) for an exploration of genes, networks and karma in #RetinalDevelopment and disease. Learn more: https://t.co/mrzMLzF2TQ
@ARVOinfo #VisionResearch

[Soumitra Pal @soumitrakp]

📢 #ISO #WetLabs in #India that do #SingleCell #RNAseq. Any leads or recommendations? Appreciate your expertise! #ScienceTwitter #Bioinformatics #Genomics #ResearchHelp #IndiaLab

[Simona Cristea @simocristea]

New preprint on scGPT: first foundation large language model for single cell biology, pretrained on 10 million cells.

Just as text is made of words, cells are characterized by genes

Some thoughts on how cool this is & why it challenges the status quo of single cell analysis🧵🧵