*Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*
Before we even get into the nutrients, you must be aware of two things.
Number 1: Each macronutrient (protein, carbs, fats) relies on specific metabolic pathways that require distinct vitamins, minerals and cofactors for optimal function.
So basically, our micronutrient needs are influenced by our macronutrient intake.
Now, here are some micronutrient adjustments you can make for certain macronutrient splits.
In general:
If you are on a high-protein diet, you need to pay attention to:
-B6: Cofactor for transaminases and decarboxylases in amino acid metabolism.
-B9: Aids in methionine metabolism.
-B7: Supports amino acid catabolism and energy production from branched-chain amino acids.
-B12: Essential for methionine synthesis.
-Magnesium: Facilitates protein synthesis.
-Molybdenum: Cofactor in the urea cycle (via xanthine oxidase), helping detoxify nitrogen waste from protein breakdown.
-Balancing methionine:glycine
-Polyphenols since too much tryptophan can increase quinolinic acid a lot and one of the most useful tools against its excitotoxicity are polyphenols.
If you are on a high-carb diet, you need to pay attention to:
-B1: Essential for pyruvate dehydrogenase.
-B3: Needed for NAD+ synthesis in glycolysis and oxidative phosphorylation.
-Magnesium: Cofactor for enzymes in glucose metabolism.
-Zinc: Supports insulin signaling and glucose uptake.
-Potassium: Supports insulin signaling and glucose uptake.
-B5 : Precursor to coenzyme A, vital for metabolizing carbs into energy via the Krebs cycle.
-Chromium: Enhances insulin sensitivity, improving glucose uptake in high-carb diets.
If you are on a high-fat diet, you need to pay attention to:
-Choline: Critical for fat transport (via lipoproteins).
-Electrolytes (Sodium, Potassium, Magnesium): Low-carb intake = can’t hold onto enough electrolytes in the long run.
-L-Carnitine: Transports fatty acids into mitochondria for energy.
-Coenzyme Q10 (CoQ10): Supports mitochondrial energy production from fats, reducing fatigue in depression.
-Glycine and taurine (for bile)
-B2: Deriving > 65 % of energy from triglyceride oxidation requires 80–100 % more riboflavin per ATP generated than an isoenergetic carbohydrate-based diet.
@billieeilish@grok please roast Eilish’s hypocrisy in hating on capitalism and “stolen land” while selling perfume and living in luxury on that same land
The LARGEST human ivermectin cancer study EVER conducted found 84% of patients declared their cancer DISAPPEARED, SHRUNK, or STOPPED SPREADING after 6 months.
Our study is now OFFICIALLY PUBLISHED by the International Institute of Anticancer Research.
Nattokinase SHRANK arterial plaque by 36% with ZERO adverse effects.
The study found 95.4% of patients taking 10,800 FU daily for 12 months experienced some degree of cardiovascular improvement.
The 36% plaque reduction was verified using carotid artery ultrasound.
THE GALLBLADDER PRESERVATION PYRAMID
A step-by-step approach to supporting your gallbladder.
If you've been told, "You have gallstones. You need your gallbladder removed," you may believe there is nothing else to consider. But before we assume an organ is destined for removal, we should ask:
What is happening to the gallbladder—and WHY?
Gallbladder preservation isn't about refusing surgery when surgery is necessary. It's about identifying people who may still have a safe opportunity to support gallbladder function, improve bile flow, reduce the factors that promote stone formation, and potentially preserve the organ.
Think of it as a pyramid.
For reasons i truly don't understand, Boswellia has to be the number 1 supplement people with gut issues are aware of but never try.
Yet:
-82% of patients taking 350 mg of Boswellia serrata gum resin three times daily for 6 weeks achieved remission, compared to 75% taking sulfasalazine (1 g three times daily).
-A small trial of 30 patients with chronic colitis reported that 14 out of 20 patients (70%) given Boswellia gum resin (300 mg to 350 mg three times daily) went into remission, compared to 4 out of 10 patients (40%) on sulfasalazine.
https://t.co/34VmAOhQ5E
It's always nice to make X News!! 😃
I have to say something about the American Society of Clinical Oncology.
$50+ billion spent on Cancer Research, and cancer patients taking cheap dewormers: Ivermectin, Mebendazole and Fenbendazole are still outperforming every Cancer Center in America! 😃
I now have hundreds of American Oncologists on record, admitting that they have never seen results like this in their careers! Mayo Clinic, MD Anderson, I have them all!
If ASCO has any reason to exist at all, it should be celebrating these results and pushing for more research funding.
"ASCO warns cancer patients there is no strong evidence for why they've gone from Stage 4 to Cancer Free"
Very good ASCO, now let's see what you can accomplish with the next $50 billion in cancer research funding 😂
Well, I guess it's still better than Grok telling cancer patients they should go home and die instead of trying Ivermectin and Mebendazole. 🫣
BREAKING: FDA approves new pancreatic cancer drug, daraxonrasib, after a key trial showed patients lived more than twice as long as those on chemotherapy.
🔥 Just published!
The lipid-lowering landscape is changing and statins are no longer the whole story.
Proud to contribute to this timely review in Frontiers.
https://t.co/p9rxq3TxUl
A new study found a SINGLE 5g psilocybin dose RESTORED speech, memory, AND bladder control in an advanced Alzheimer’s patient.
After 1 month, the patient was STILL functionally improved.
No approved drug has EVER done anything close.
"I am so tired during the summer".
Dude, you sweat like a racehorse and consume the amount of potassium that's in one banana and the amount of sodium that's in one 3 bottles of soy sauce.
No shit why you're tired.
"Ignore bananas for potassium. Meat has more".
*Sodium : potassium ratio. Sodium : potassium ratio. Sodium : potassium ratio.
PREGNENOLONE: A fountain of youth
1. Pregnenolone lowers stress - restores youthful appearance
As we age, we:
☞ Put on more fat
☞ Lose muscle
☞ Produce less energy
☞ Do so in a more stressful manner
The primary stress hormone, cortisol, actually predicts your perceived age.
In other words, the lower your stress, the younger you appear to other people, and the younger you likely are biologically!
Stress directly promotes the breakdown of
☞ Skin
☞ Hair
☞ Muscle
while promoting the creation of fat mass.
Pregnenolone INHIBITS the release of CRH, the hypothalamic precursor of cortisol.
Prengnolone’s ability to inhibit the release of CRH/CRF is unique, targeting stress at the most basic biological root cause.
Pregnenolone also functionally inhibits the receptor for cortisol.
The "pregnenolone facelift" phenomenon is real.
The production of pregnenolone and its metabolites like DHEA, declines in aging, while the production of stress steroids like cortisol continue to rise.
The ratio of DHEA/Cortisol is one of the best predictors of disease and mortality, and declines with aging.
Pregnenolone also gets metabolized in large quantities to progesterone, which also inhibits CRH release and is a direct antagonist on the cortisol receptors.
Progesterone has GABAnergic effects, which is the key relaxing signaling molecule in the body.
Another compound which pregnenolone largely gets converted into is allopregnanolone, our body’s primary endogenous GABAnergic steroid.
2. Pregnenolone is anti-inflammatory
CRH, independently of cortisol production, also contributes to stress, disease and aging, by initiating inflammation.
Inflammation is uniformly seen in all chronic diseases and in the aging process, as it
☞ Breaks down our tissue
☞ Dampens energy production
☞ Generally makes us feel crappy
Pregnenolone actually degrades the toll like receptors (TLRs) that initiate inflammation in conditions from Alzheimer's disease to IBS.
These types of conditions are things we help our clients with daily. If you want personalized help with that, just click the link in my bio to schedule a free call.
3. Pregnenolone increases energy
As we age, our mitochondria become:
☞ More susceptible to damage
☞ More fragmented
☞ Smaller
☞ Less effective at producing energy,
☞ More prone to generate free radicals
but pregnenolone allows them to
☞ Produce more energy,
☞ Produce less with oxidative stress
☞ Undergo fusion, when mitochondria come together and become more robust.
The pro-energy effects of pregnenolone have been observed for nearly a century.
Some early studies showed that workers, especially those under stress, subjectively felt better when doing so with pregnenolone.
This anti-fatigue effect was also demonstrated in arthritic patients.
100-500 mg of pregnenolone taken orally has consistently shown an anti-fatigue, cognitive enhancing and anti-stress/anxiety effect.
I'll link the pregnenolone we use ourselves and with clients below.
Perhaps the most noteworthy testimonial:
" 'I didn't have my usual summer recovery from "winter sickness,' during a two week trip I felt perfectly well, but except for that short time I kept getting sicker and sicker (with inflammation of arteries, dental abscesses, asthma, migraines, and colitis).
Lying in bed one day trying to understand what had happened during that two week trip, I remembered that I had used the vitamin E containing a residue of pregnenolone on the trip, but used pure vitamin E after I got home.
I immediately got out of bed and took a pinch of pregnenolone. In about an hour, all of my
symptoms had stopped, and for over a week I was healthy and energetic.
But then I got sick again, and was so distracted by the pain that it was several days before I remembered the pregnenolone. Another pinch had the same dramatic sudden effect.
Since then I have taken some almost every day."
- Ray Peat
Look at his transformation!
Did you know that, on average, 25% of patients suffering from gastrointestinal motility (and some functional) disorders have low vitamin B1 levels?
That's 1 in 4 people whose gut issues come from a thiamine deficiency.
Without B1, the vagus nerve cannot make acetylcholine, meaning your stomach acid drops and your MMC almost shuts down.
But thiamine (B1) is responsible for much more.
So here's how to properly use thiamine for your chronic fatigue, gut issues and much more.
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