Humboldt Research Fellowship 2027 in Germany | Fully Funded
🔗 Visit: https://t.co/jP8ofqrU7y
Benefits include: Monthly stipend (€3,000–€3,600), travel allowance, health insurance support, free German language course, family allowances, and strong academic support.
📍 Duration: 6–24 months
🌍 Open to applicants from all countries
A great study by the Hoffmann lab in @JExpMed shows innate immune memory can be propagated in a cell-extrinsic way via local cytokine trapping. In our Insight, Luca Frosio and I discuss how these findings suggest spatial niche-specific contron of trained immunity 🎯
The Alzheimer’s therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia @NatureNeuro
https://t.co/mAaXy9O8Mg
Deadline approaching! Submit your short talk abstracts or scholarship apps for the Symposia on Aging by Nov 20 (11:59pm MST). Don’t miss your chance to share your work with leading experts
🔗 https://t.co/hzcNR37TsK 🎥 https://t.co/wcalTMTS1d #KSAging26#KSAging26#aging
And #COVID can also damage the vision by crossing the blood-retinal barrier after systemic exposure. And don't forget the retina is part of the brain. #NeuroCovid
More here: https://t.co/Ew2ZafNrmD
A new Science #Immunology study in mice suggests that ectopic lymphoid follicles in the meninges may contribute to disease progression in #MultipleSclerosis by promoting T–B cell interactions that enhance #autoimmune inflammation. https://t.co/onV8waLaK7
Online now: Monocytes can efficiently replace all brain macrophages and fetal liver monocytes can generate bona fide SALL1+ microglia https://t.co/dimmbmysB9
📢 New webinar coming soon 📢
Dr. Gilbert Di Paolo from Denali Therapeutics will be our next speaker on February 4th. Check all the information in the flyer and add it to your calendar!
I think the field needs to start reconsidering #microglia as The single most important mediator of #SynapticPruning, a widespread concept.
We offered our Perspective on whether microglia are hunters or gatherers of brain synapses here
https://t.co/GZhdzSyx6i
Mind The Time! What time do you collect #microglia from your preclinical model for downstream analyses? Microglia undergo #transcriptional, #proteomic and #functional adaptations to the wake and sleep phases🧵https://t.co/KOFu1C1BLB
Immunohistochemical staining with Glyoxal as Fixative
9% Glyoxal/8% acetic acid
No antigen retrieval needed
PBS+ 0.1% Triton X-100
vs Formaldehyde fixation
▶️⏫immunostaining intensity
▶️Make FFPE-incompatible antibodies useful
Working on paraffin section, ultrathin resin section, & whole-mount tissue (with optical clearing)
▶️Less tissue preservation
Are we ready to replace 4% PFA or 10% formalin with glyoxal?
Let's test how serial sectioning & staining of glyoxal-fixed human muscle!😁
Masahiko Watanabe lab @ScienceAdvances 2023
https://t.co/iuqKuxosK7
Finally out! Check out our new paper in Nature Communication 10.1038/s41467-024-49596-0. In this new study, we established that microglia make their own TGF-β1 ligand to maintain brain homeostasis and cognitive function via autocrine signaling mechanism at a single-cell level!