Sunny Tzu-Ching Su

1st year PhD Student at Indiana University School of Medicine / Alzheimer’s Disease | Therapeutic Development | Neuroimmunology

[Nat Rev Neurology @NatRevNeurol]

Priming of CD8+ T cells by peripheral dendritic cells exacerbates tau-mediated neurodegeneration https://t.co/7M9xFMmnG9

[Network Glia | European Glia Meeting @gliameeting]

Microglial #autophagy helps contain amyloid plaques and prevents cellular #senescence. Disruption worsens pathology, while removing senescent #microglia improves outcomes—highlighting a promising therapeutic avenue in #AlzheimersDisease.

https://t.co/6miTS1vzcn

[Waggoner Lab @LabWaggoner]

@biorxivpreprint Depletion and replacement of tissue resident macrophages in mice with germ-line deletion of a conserved enhancer in the Csf1r locus
https://t.co/EeLkkkB39U 🇦🇺

[Waggoner Lab @LabWaggoner]

Genetically altered chimeric antigen receptor astrocytes targeting amyloid-β reduce a cardinal pathological feature of Alzheimer’s disease @ScienceMagazine @TheColonnaLab @WashU
https://t.co/vrK9RCO1I7
https://t.co/uJLSl1ZTV7

[Science Signaling @scisignal]

The calcium channel Orai1 present in immune cells called #microglia may explain how neuroinflammation can induce depressive-like behaviors, according to new experiments in mice in this week’s issue. @NUFeinbergMed https://t.co/arguFJ2xvN

[Alzforum @alzforum]

Could Zolpidem benefit people with Alzheimer’s disease? In amyloid mouse models, the sleep drug nudged down amyloid a lot, and nudged up memory a tad. @MassGeneralNews https://t.co/WNIwZbC3c6

[John Lukens @LukensJohnR]

cGAS-mediated IFN-I signaling contributes to disease progression in drug-refractory epilepsy https://t.co/YjsCd1oKX5

[Carlos Cruchaga @ccrugom]

Aging populations make neurodegenerative diseases an urgent challenge.
Our review shows how genomics, transcriptomics, and proteomics are reshaping our understanding of AD, PD, DLB, and FTD—revealing pathways, biomarkers, and new therapeutic opportunities https://t.co/3HCBCOUA8i

[IdoAmitLab @IdoAmitLab]

Excited to share two back-to-back studies with @jonykipnis @boskovic_p showing the promise of CAR T beyond cancer — in Alzheimer’s and stroke — inspired by the visionary work of Zelig Eshhar.

[Pavle Boskovic @boskovic_p]

Excited to share our new paper out in PNAS today: we developed amyloid-β–targeting CD4 CAR-T cells and demonstrate their ability to alter amyloid pathology and immune dynamics in an Alzheimer’s disease models.
https://t.co/XEMZOv0B8W

[nature @Nature]

Parkinson’s disease has the fastest-growing prevalence of any neurodegenerative disorder worldwide

https://t.co/ncLeJCrNcJ

[WashU Medicine Knight ADRC @WashUMedADRC]

Researchers find new way to slow memory loss in Alzheimer’s | Cold Spring Harbor Laboratory https://t.co/QPsMhfnlMe

[John Lukens @LukensJohnR]

Generation and characterization of iPSC‐derived microglia for in vitro modeling of stimuli‐specific neuroimmune responses @alzdemjournals https://t.co/AzIufFxk0n

[Pluchino lab - Regenerative Neuroimmunology @Pluchinolab]

TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism https://t.co/VMPNu6mtaw

[John Lukens @LukensJohnR]

Clonal CD8+ T cells populate the leptomeninges and coordinate with immune cells in human degenerative brain diseases
https://t.co/VUQTqrWcnn

[Fei Dong @daydreamerscent]

@AOSasmita and @ConstanzeDepp insightfully discuss non-neuronal Amyloid-β production and amyloid precursor protein processing in non-neuronal cells in the context of #AlzheimersDisease. See here: https://t.co/SXuXcrD4ry

[Nature Metabolism @NatMetabolism]

AMPK at the interface of nutrient sensing, metabolic flux and energy homeostasis https://t.co/U863JNMaSA

[Gilles Gouspillou @GGouspillou]

Mitochondrial transfer from glia to neurons protects against peripheral neuropathy | Nature https://t.co/70DfpvAADf

[John Lukens @LukensJohnR]

State-specific enhancer landscapes govern microglial plasticity https://t.co/zDRwehWKH4

[Trends in Immunology @TrendsImmuno]

Microglia in systemic neuroimmune communication: functions beyond phagocytosis https://t.co/Y057bIcE5L #immunology