Frankel Lab, Imperial College London

Frankel lab, Imperial College London.
#microbiome #hostpathogen #t3ss -
Tweets from lab members.

[Frankel Lab, Imperial College London @TheFrankelLab]

Great visit to Tokyo University. Thank you Hideaki and Chiho for wonderful hospitality.

[Tomoko Kubori @tomoko_kubori]

Thank you, Gadi ⁦@TheFrankelLab⁩, for visiting us in Gifu and for the wonderful talk with many inspiring topics!

We totally enjoyed your lecture and the pleasant time over dinner and the Ukai cruise with you❣️

[Frankel Lab, Imperial College London @TheFrankelLab]

We are happy to share our new preprint characterising production of the conserved polysaccharide PNAG, a potential vaccine target produced by many pathogens, in #Klebsiella pneumoniae during infection. Congratulations to everyone involved,especially Jonny! https://t.co/wyy5aVsjBb

[Frankel Lab, Imperial College London @TheFrankelLab]

We are happy to share our recent results on conjugation surface exclusion with a chromosomal twist. Must mention Chloe’s and Sophia’s incredible contributions.

Cryo-EM structure and evolutionary history of the conjugation surface exclusion protein TraT https://t.co/9EQypfWZvC

[Aran Singanayagam @SinganayagamLab]

New paper from the lab now published @NatureComms We show that NETs drive immunopathology in exacerbated #COPD. Work led by the talented @OrestisKats (now moved onto pastures new) with help from our friends @ProfJDChalmers group.

https://t.co/1OOmeyM7CJ

[Frankel Lab, Imperial College London @TheFrankelLab]

Counterintuitively, induction of hyper gut inflammation restores neutrophil migration and infection resolution. Big thank you to everyone involved! @CBRB_Imperial @ImperialSci @ImperialMDR

[Frankel Lab, Imperial College London @TheFrankelLab]

We are happy to share our recent publication linking severe infectious colitis with reduced migration of neutrophils to the infection site, leading to their accumulation in the submucosa where they undergo NETosis causing tissue damage: https://t.co/0E8NG62xTQ

[Frankel Lab, Imperial College London @TheFrankelLab]

Global, regional, and national incidence and mortality burden of non-C... https://t.co/e7KsRIbtZt

[Waggoner Lab @LabWaggoner]

Subset of absorptive colonic epithelial cells elicit MHCII-dependent help from IL-22+ T cells to orchestrate regional immune protection against Citrobacter in the intestine @Nature @cgarrettwilson Weaver & Zindl
https://t.co/lEFAt2PHwa

[Frankel Lab, Imperial College London @TheFrankelLab]

Complement in breast milk modifies offspring gut microbiota to promote... https://t.co/hgAHabfaND

[The Infectious Diseases Research (Gal-Mor) Lab @InfectiousGal]

How does Salmonella infection become persistent? We are so proud to share our publication in @cellhostmicrobe
Congratulations to Alex, Bar, Jonathan, Ashlee and all the coauthors. That was an amazing journey with @sheba_medical and @broadinstitute
https://t.co/m75xegHCLs

[Luis Ángel Fernández @lafdez_synbio]

Excellent news for @PharmaT3 and for the whole field of therapeutic synthetic bacteria !

German pharma company acquires University of Basel start-up for 450 million Swiss francs | University of Basel https://t.co/m0dZpoL5DS

[C. LESTERLIN - TacC LAB @tacc_c]

New publication from the TacC Lab in collaboration with the Erhardt Lab. A long-awaited proof of DNA transfer via the extended conjugation pilus.
https://t.co/cY1mv91coH

[Frankel Lab, Imperial College London @TheFrankelLab]

Functional features of KPC-109, a novel 270-loop KPC-3 mutant mediatin... https://t.co/7IBkiKR1eP

[Frankel Lab, Imperial College London @TheFrankelLab]

Bacterial pathogens deliver water- and solute-permeable channels to plant cells https://t.co/ayDX8eu9MU

[Imperial Department of Infectious Disease @ImperialInfect]

🦠 Research from @CBRB_Imperial shows that antibiotics promote the growth of antibiotic-resistant bacteria in the gut.

The study could lead to better patient risk assessment and treatments to help combat antibiotic-resistant bacteria. ⤵️
https://t.co/qJVrRw2HCy

[Sorek Lab @SorekLab]

Proud to share our latest discovery: Bacteria conjugate ubiquitin-like proteins to interfere with phage assembly

A new concept in antiphage immunity, and a mechanism for ISG15-like antiviral defnese in bacteria. Big congrats to talented @Jens_Hoer!

A 🧵
https://t.co/w9TQ9zf0yx

[Frankel Lab, Imperial College London @TheFrankelLab]

Very happy to share our review and view on bacterial conjugation
Plasmids pick a bacterial partner before committing to conjugation https://t.co/GGcYvnCCy6

[Frankel Lab, Imperial College London @TheFrankelLab]

Huge congratulations for this great story @BenWiggins_093, @cschieri and everyone else that contributed! Check out the article (and thread) if you want to know more about the importance of endothelial cells in maintaining gut health 🦠����🧍

[Ben Wiggins @BenWiggins_093]

I am delighted to announce our manuscript on aryl hydrocarbon receptor (AHR) ligand sensing by gut endothelial cells is now out in @Nature! This has been a lot of collective hard work over the last 3 years, and I am proud to see this work across the line! https://t.co/23fxaGMcUH

[JChen Lab @JchenLab]

Thanks to @gileadamit @TheEconomist for wading into the world of SaPIs and phages! Making science accessible to the public is tough work. I can barely explain it to other scientists!

Tiny hitchhikers on viruses could promote resistance to antibiotics https://t.co/fSK18jtynX