Matthias Lutolf

Institute of Human Biology (IHB), Roche, Basel, Switzerland. Institute of Bioengineering, EPFL, Switzerland. #organoids, #tumoroids, #stemcells, #bioengineering

[Matthias Lutolf @TheLutolfLab]

@CedricBlanpain @ChenJiang919 @yura__song @Alessia100nze Huge congrats @CedricBlanpain, @ChenJiang919 and team to this beautiful paper! We are happy that we were able to make a small contribution.

[Matthias Lutolf @TheLutolfLab]

Transgels enable live imaging of parasite infection in caecal models. Watch larvae invade epithelia in real-time & observe mechanisms like syncytial tunnel formation. Huge congrats to super talented @MoritzHofer_ and thanks to Maria Duque-Correa for the fantastic collaboration!

[Matthias Lutolf @TheLutolfLab]

Bioengineered GI organoids just got an upgrade! Our new Transgel system combines 3D complexity with bilateral accessibility & remarkable observability, enabling advanced studies on tissue dynamics, stem cell niches, and host-pathogen interactions.🔬
��� https://t.co/OeiSs0ehdO

[Matthias Lutolf @TheLutolfLab]

From gastric to colonic tissues: Transgel organoids replicate GI tissue architecture, including stem cell patterning and improved differentiation over time! There seem to be conserved mechanisms for geometry-induced stem cell organization and differentiation across the GI tract.

[Matthias Lutolf @TheLutolfLab]

Join us @Roche's Institute of Human Biology (IHB) as a Scientific Group Leader! Lead innovative research in #HumanModelSystems such as #Organoids. We especially seek applications aligned to our commitment to diversity and inclusion.  More https://t.co/3uVStARGPR  #TeamIHB #pRED

[Matthias Lutolf @TheLutolfLab]

Please join us in shaping the future of human biology research and help to translate it into real-world applications in pharmaceutical research and development!

[Institute of Human Biology @IHB_Research]

📢Open call for Scientific Group Leads! #TeamIHB seeks stellar Junior & Senior scientists to start research groups on innovative and translational #HumanModelSystems. Expertise in #Immunology, #Neurology, #Ophthalmology, #Metabolism or #Oncology a➕! More https://t.co/iM4y4WwbdL

[Matthias Lutolf @TheLutolfLab]

@milicaruoft @Roche @IHB_Research @AnnieMoisan_wl @ElisaDarcangelo Many thanks for the fascinating lecture and the introduction to the art of organ-on-a-chip engineering and its implementation into real-world applications!

[Matthias Lutolf @TheLutolfLab]

@SonnenKatharina congrats!

[Matthias Lutolf @TheLutolfLab]

Fantastic paper that exemplifies the credo and mission of @IHB_Research: bold and creative young scientists as hands-on leads + projects combining biology, engineering, computation and drug development + extremely close collaboration between multiple research groups! Congrats!!

[Gray Camp @GrayCampLab]

Exciting new inroads into human biology and therapy development: Human intestinal organoids with an autologous tissue-resident immune compartment! #Gjorevski #Cabon #IHB @Nature @IHB_Research https://t.co/x6YWSjl8yp

[Matthias Lutolf @TheLutolfLab]

This work has been led by the brilliant @LFranciscoLM, with invaluable support from @NicoBroguiere, @JakobJLanger, Lucie Tillard, @mike_nikolaev, @CoukosGeorge, and Krisztian Homicsko. 🙏🙏!!

[Matthias Lutolf @TheLutolfLab]

Following our recent breakthrough on mouse mini-intestines for ex vivo tumor development, we asked ourselves: can this technology be applied to cells from cancer patients? We are excited to announce the answer to this question in our latest publication: https://t.co/Uck4EyBXeK

[Matthias Lutolf @TheLutolfLab]

and the identification of immunomodulatory interactions among different components of the tumor microenvironment.

[Matthias Lutolf @TheLutolfLab]

@kafloyd06 thanks!

[Matthias Lutolf @TheLutolfLab]

Imagine growing a miniature version of the human intestine in the lab to study gut biology in great detail and test medicines before clinical trials? We are happy to share our latest publication on bioengineered human mini-intestines: https://t.co/0AvDkk9R3S Let’s dive in!

[Matthias Lutolf @TheLutolfLab]

@OttiCroze @mmanich75 Thanks! Yes, ongoing work with colleagues at IHB

[Matthias Lutolf @TheLutolfLab]

@dagarfield Thanks, David! Will do 😄

[Matthias Lutolf @TheLutolfLab]

@AIneurolab thanks!

[Matthias Lutolf @TheLutolfLab]

@AProfAram thanks!