Thorén lab

NK cells; neutrophils; cytokines; cancer; inflammatory diseases etc |@sahlgrenskaAcad | @goteborgsuni

[Thorén lab @thoren_lab]

We are hiring!
Join our great team as a PhD student to develop future’s NK cell-based immunotherapy! Fully funded 4-year position available at Sahlgrenska Center for Cancer Research in Gothenburg.
Apply before Feb 27, or please spread in your network! https://t.co/9Ka2becHHZ

[Quirin Hammer @QuirinHammer]

Happy to share the final work from my post-doc with @MalmbergLab published in @CellStemCell today https://t.co/ZcC8Q32kts
extensive 15-post-🧵 below

[Thorén lab @thoren_lab]

Dissertation day @goteborgsuni @SahlgrenskaAcad.

Excellent performances by @LinneaKristensn and faculty opponent @MalmbergLab. 🥂🥳🍾 #nkcells #crispr

[Thorén lab @thoren_lab]

TMEM30a mutations are recurrently found in lymphoma, and our study thus suggests that this may be an NK cell-evasive strategy in these malignancies. Thanks to co-authors @chiarabadami256 @BrwaAliHussein @group_tang @YarongTian @FbThoren and others not on X/Twitter

[Thorén lab @thoren_lab]

It is out in PNAS!
A new study, led by @LinneaKristensn from us demonstrates that loss of function mutations in TMEM30a enable escape from NK cell cytotoxicity.
https://t.co/oBHsjkdmGF
A thread...

[Thorén lab @thoren_lab]

The NK-resistant phenotype of TMEM30a-deficient cells was not specific for K562 cells. Several leukemia and lymphoma cell lines displayed elevated PtdSer levels and reduced sensitivity to NK cells after deletion of the TMEM30A gene.

[Thorén lab @thoren_lab]

Great performance by @hana_komic today when she defended her PhD thesis! Thanks to faculty opponent @BjornTG

[Thorén lab @thoren_lab]

Celebration day in the lab! @hana_komic nailing her thesis before the dissertation on Feb 29th. @goteborgsuni @SahlgrenskaAcad @sahlgrenska

[Mjösberg Lab @MjosbergL]

Interested in single cell sequencing and have a passion for cancer or mucosal immunology? Come join our lab! A great opportunity to grow your career as a postdoc: https://t.co/DciOXkAGSj

[Thorén lab @thoren_lab]

Today on World #CML day, we are happy to present our latest preprint on leukemic stem cells #LSC. For the first time, we combine CITEseq with concomitant BCR-ABL1 detection. Great collaboration with @Martnerlab @MalinNilsson__ @hana_komic https://t.co/qcil05mWCc

[Brwa Ali Hussein @BrwaAliHussein]

Thrilled to see our latest work @thoren_lab is published!

We reported biological/clinical impact of NKG2A rs1983526 https://t.co/UeD31C6jrr

Grateful to all co-authors for their help and input!

Thank you to the editor/reviewers & the rest of #JITC team for their efforts!

[Journal for ImmunoTherapy of Cancer @jitcancer]

New #JITC article: NKG2A gene variant predicts outcome of immunotherapy in AML and modulates the repertoire and function of NK cells https://t.co/MTI8nLtaBP @thoren_lab @BrwaAliHussein

[Johan Norberg @johanknorberg]

How did Sweden fare during the pandemic? Back then, the world was shocked by our openness. New York Times called us a “cautionary tale”, Trump said “Sweden is suffering very greatly”. But we never heard how it all turned out.

Now I’ve looked: Sweden did better than others. 🧵

[Malcolm Sim @mjwsim]

Last chance to apply for this postdoc position in my group!

[@SN_Oncology @SN_Oncology]

HLA-B*44 and the Bw4-80T motif are associated with poor outcome of relapse-preventive immunotherapy in acute myeloid leukemia: https://t.co/zDL8tzRK1I #AML #CancerImmunotherapy #NKCellTherapy

[Thorén lab @thoren_lab]

We found that individuals with this weak 80T-Bw4 ligand had less functional NK cells and inferior survival after HDC/IL-2 immunotherapy in AML.
Thanks to all involved, @elinbernson @BrwaAliHussein @chiarabadami256 and others not on Tw/X

[Thorén lab @thoren_lab]

Happy to see this paper out in CII, a project started by @Hallner90 and finalized by @hana_komic. Full text here, https://t.co/8nXgZeBACT
@SahlgrenskaAcad @goteborgsuni
A short 🧵...

[Thorén lab @thoren_lab]

The association w inferior survival was not shared across the HLA-B44 supertype, which comprises HLA-B alleles that present similar peptides. But interestingly, HLA-B*44 harbors an 80T-Bw4 motif – a weak ligand to the NK receptor KIR3DL1.