Christophe Galichet

Researcher at @thecrick via #NIMR and @IGBMC / interested in genome editing, stem cell and animal in science / food passionate & school governor

[Christophe Galichet @tin_tooh]

@Dan4Barnet do you find it acceptable to stop hard worker constituent to get to work on time?

[Christophe Galichet @tin_tooh]

@TfL why passengers are not your priority? Cancelling train from Mill Hill East and the train before that closed the door on passenger and stayed on the platform for 30s refusing to reopen the door 😤

[Christophe Galichet @tin_tooh]

@TfL why passengers are not your priority? Cancelling train from Mill Hill East and the train before that closed the door on passenger and stayed on the platform for 30s refusing to reopen the door 😤

[Christophe Galichet @tin_tooh]

@TfL why passengers are not your priority? Cancelling train from Mill Hill East and the train before that closed the door on passenger and stayed on the platform for 30s refusing to reopen the door 😤

[Christophe Galichet @tin_tooh]

https://t.co/mHnwC8InlN

[Christophe Galichet @tin_tooh]

Poop saved my research #reproducibility. Thanks to ⁦@TheCrick⁩ https://t.co/cgSIfElgjw

[Labroots @Labroots]

The Impact of Genetic Mutations may be Affected by the Gut Microbiome | "It was a huge surprise to find that changes in the gut microbiome reversed hypopituitarism..." said Dr Christophe Galichet. #microbiome https://t.co/2AGp9Mk7Aj

[Christophe Galichet @tin_tooh]

Mon ancien patron et moi donnons un résumé de l'article (en anglais)

https://t.co/mnNL9iEFMa

[Christophe Galichet @tin_tooh]

Un article discutant de la reproductibilité en science, des traitements thérapeutiques potentiels (aspirine ou microbiote intestinal) et du type cellulaire à l'origine d'une maladie génétique rare affectant les niveaux d'hormones (Sox3).

https://t.co/mHnwC8HPwf

[Christophe Galichet @tin_tooh]

Je n'aurais jamais pensé que déplacer des souris d'un institut à un autre aurait un impact énorme sur mes recherches (perte de phénotype). @TheCrick

@EARA_FR

[Christophe Galichet @tin_tooh]

Research reveals surprising impact of gut microbiome on hormone levels in mice https://t.co/oYxD4RAMau

Thanks @AMIposts for the article!

[Neuroscience News @NeuroscienceNew]

@tin_tooh 2 - Aspirin treatment and gut microbiome changes reversed hypopituitarism in mice.

[Neuroscience News @NeuroscienceNew]

Gut Microbiome and Aspirin May Reverse Hormonal Issues

Researchers have discovered that mutations in the Sox3 gene lead to hypopituitarism, a condition where the pituitary gland produces insufficient hormones, causing growth issues and fertility problems.

The study found that the mutation affects NG2 glia cells in the brain’s hypothalamus, which are crucial for hormone regulation.

Treating mice with low doses of aspirin or altering their gut microbiome restored NG2 glia levels and reversed the symptoms of hypopituitarism.

The surprising role of the gut microbiome suggests that environmental factors can influence genetic conditions.

The findings offer potential for developing treatments targeting the gut microbiome or using aspirin to treat hormone deficiencies.

Future research will explore the precise mechanisms behind these effects and their application in humans.

[Christophe Galichet @tin_tooh]

How the mouse microbiome impacts hormone levels, discovered by chance https://t.co/EzZ4LHecjw via @YouTube

@newscientist @ScienceNews @ScienceMagazine @guardianscience @WIREDScience @wonderofscience @France24_en @SkyNews

[Christophe Galichet @tin_tooh]

@TheCrick @SWC_Neuro @NC3Rs @LASA_UK @BBCScienceNews reproducibility in science - here a story of not being able to reproduce my own data - importance of gut microbiota

https://t.co/mHnwC8InlN

[The Francis Crick Institute @TheCrick]

When moving mice from one of our predecessors to our new building in 2015, a chance discovery helped Crick scientist Christophe, now at @SWC_Neuro, find that the microbiome impacts hormone levels in mice 🏫🐁 https://t.co/ljMAZsREaR

[Christophe Galichet @tin_tooh]

One open question would be how widespread is the influence of our gut onto disease appearance
#nature versus #nurture

[Christophe Galichet @tin_tooh]

‘You are what you eat’ now makes total sense.

A paper discussing reproducibility in science, potential therapeutic treatments (Aspirin or gut microbiora) and the cell type at the origin of a rare genetic condition affecting hormone levels (Sox3).

[The Francis Crick Institute @TheCrick]

When moving mice from one of our predecessors to our new building in 2015, a chance discovery helped Crick scientist Christophe, now at @SWC_Neuro, find that the microbiome impacts hormone levels in mice 🏫🐁 https://t.co/ljMAZsREaR

[Christophe Galichet @tin_tooh]

I could have never done without the support from past and current members of the lab, friends and colleagues @TheCrick and previously at NIMR , and, more recently, colleagues @SWC_Neuro .

[Christophe Galichet @tin_tooh]

@GunesTaylor They are so lucky to have you. Congrats! You will be brilliant (as usual).