Sofia Toniolo

Neurologist (MD, DPhil, MRCP, FEBN) - in love with AD research - Senior Research Fellow in Cognitive Neurology at the University of Oxford

[Jake Vogel @_JakeVogel_]

‼️Alert‼️Massive open dataset release!!

The world’s largest proteomics dataset for neurodegenerative disease, including:
* 250M+ protein measurements
* 35,000 biosamples
* 23 contributing cohorts
* +50 harmonized clinical variables
* AD / PD / FTD / ALS / Normal Aging

1/

[Masud Husain @MasudHusain]

What are the mechanisms underlying apathy in people with #AlzheimersDisease and subjective cognitive impairment? Here's a first attempt to answer this question using effort based decision making for reward by @bahaatallah @toniolo_sofia @neuroRaquel
https://t.co/MiStjGqIBY

[Sofia Toniolo @toniolo_sofia]

@SJ_Schreiner Totally agree!

[Chuck Lynch @cl9681]

Happy to share that our work applying precision mapping to individuals with depression sampled longitudinally over an extended period has been published this week in @nature. Brief recap of the main findings and their potential implications below.

https://t.co/ZbTj6x7eyV

[Sebastian Palmqvist @SebastianPalmqv]

Very proud of this study! We have worked for many years now and finally show that BBMs work when implemented prospectively in primary and secondary care.

[RikOssenkoppele @RikOssenkoppele]

Revised criteria for diagnosis and staging of Alzheimer’s disease

The criteria will obviously have a profound impact on the field. Couple of key points:

1⃣ Alzheimer's disease is defined as a biological process that begins with the appearance of AD neuropathologic change while people are asymptomatic.

2⃣ An abnormal "early-stage" Core 1 biomarker (amyloid PET, approved CSF biomarkers, accurate plasma biomarkers) result is sufficient to establish a diagnosis of AD.

3⃣ Later-changing Core 2 biomarkers (biofluid and tau PET) can provide prognostic information and increase confidence that AD is contributing to the symptoms.

4⃣ The criteria are not intended to provide step-by-step clinical practice guidelines for clinical workflow or specific treatment protocols.

Link to paper @alzdemjournals >
https://t.co/SceTVZp91k

[RikOssenkoppele @RikOssenkoppele]

Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS

Very promising study!

Background: Minimally invasive biomarkers are urgently needed to detect molecular pathology in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS).

Main result: Plasma extracellular vesicles (EVs) contain quantifiable amounts of TDP-43 and full-length tau, which allow the quantification of 3-repeat (3R) and 4-repeat (4R) tau isoforms.

Conclusion: The combination of EV TDP-43 levels and EV 3R/4R tau ratios may aid the molecular diagnosis of FTD and ALS, providing a potential biomarker to monitor disease progression and target engagement in clinical trials.

Link to paper @NatureMedicine >

https://t.co/uHoBm8U3MJ

[Sofia Toniolo @toniolo_sofia]

Digital testing is increasingly used in Alzheimer's Disease. There are plenty of platforms out there, but very few can be administered fully online, are patient friendly and validated against AD biomarkers. Check out Sijia's Zhao amazing platform - OCTAL! https://t.co/v047EJH5hk

[Bahaa Attaallah @bahaatallah]

Very happy to finally see this one out in @NatureHumBehav after a few years in the making!

With @PetitetPierre @BrainInTheMind @MasudHusain @toniolo_sofia @neuroRaquel @Mayo_AING @NDCNOxford

https://t.co/BqhA9qM6wS

[Masud Husain @MasudHusain]

It's one thing to have plasma biomarkers for #Alzheimers but which one is most closely related to cognitive function. Our @UniofOxford experience led by @toniolo_sofia & @sijiazhao92 using digital cognitive testing platform reveals pTau to be the winner
https://t.co/TzzAMLgI8v

[Michele Romoli @MicheleRomoli]

Hey @EpilepsiaJourn, it seems CT perfusion can catch status epilepticus in time!
@ISA_AII_Young congress in @univaq

[Alzheimer's Research UK @AlzResearchUK]

Two world-class research teams – based at @ucl & @DementiasUK at @UniofOxford - will carry out UK-wide clinical trials to identify blood tests to boost dementia diagnosis.

We hope this will lead to blood tests for diagnosing Alzheimer’s & other forms of dementia becoming available on the NHS within five years.

[Nicholas Ashton @NicholasAshton]

You may not know it but a significant amount of signal from #pTau217 blood tests come from p-tau212.

This study developed #pTau212 specific antibodies & evaluated its individual contribution as a blood Biomarker for #Alzheimers

Led by Przemek Kac

https://t.co/V7fghte5h5

[Marc Suárez-Calvet 🧠🧪 🩺🌈 @M_SuarezCalvet]

Ultrasound Blood–Brain Barrier Opening and Aducanumab in Alzheimer’s Disease | NEJM https://t.co/wJ8Ao0f1Gz

[Michele Romoli @MicheleRomoli]

NCSE is a time-dependent neurological disease. Hyperperfusion on CTP may suggest #statusepilepticus and save time for treatment. Think about a pragmatic workflow!
Have a look at our paper out @JNNP_BMJ
Led by @ZiniAndrea @AUSLBologna
https://t.co/uvbMq7fQ83

[Sofia Toniolo @toniolo_sofia]

Amazing discovery of new hybrid cells that lie between neurons and astrocytes - likely to be key players for hyperexcitability in the CNS, with potential implications for AD. Check out the article in Nature! https://t.co/LfMusm8jiC

[Masud Husain @MasudHusain]

We're looking for a dynamic person to join us @UniofOxford as a Research Co-ordinator on an exciting new @wellcometrust Discovery Award to study motivation and apathy in health and in brain disorders, with Cath Harmer @OxfordPERL @brain_apps @littleneuro
https://t.co/J5Pj9L7BV6

[Masud Husain @MasudHusain]

Some of the cognitive, neurological and psychological effects of #COVID on the brain discussed in our new review with @sijiazhao92 @toniolo_sofia @ProfHampshire
https://t.co/Estl9ek1PT

[Sofia Toniolo @toniolo_sofia]

What a week! Thanks #AAIC2023 for the great science and very inspiring talks - including new criteria for AD, exciting results from the phase 3 Donanemab trial, and new developments in the fields of plasma biomarkers and digital tools!

[Adolfo García @AdolfoMGarcia]

Fantastic and productive Include meeting in Amsterdam, with friends and colleagues from all over the world. For more equitable language research on brain health.

@UdeSA @CNCUdeSA @UsachFAHU @GBHI_Fellows @atlanticfellows @include_network @LACCD9 @ReDLat_Dementia @gerochile