Urinary nitrite testing introduces diagnostic confusion without adding value with regard to the decision to treat
False +ve: asymptomatic bacteriuria, contamination
False -ve: UTI due to non nitrate–reducing bacteria (e.g. Enterococcus, Acinetobacter species)
H/t @ABsteward
Great recap, @PaulSaxMD.
Just sharing a few other #ESCMIDGlobal2025 pearls from the slides that caught my eye:
- Mortality was ~3x higher when source control lagged - antibiotic choice only goes so far.
- Flu(clox)acillin nephrotoxicity is real, not just an AKI epiphenomenon.
- PCN G may be better than ASPs for PSSA (posterior Pr superiority 0.89 for mortality, 0.98 for nephrotoxicity).
- Cefazolin non‑inferior to fluclox with lower early mortality and less nephrotoxicity; HR 0.87 (95 % CI 0.67–1.15).
And < 1 % of > 6,200 patients in high‑quality SAB RCTs (SNAP + BALANCE) were enrolled in the U.S. 😬
#SNAPtrial #StaphBacteremia @syctong @Josh_S_Davis
SNAP/COLCEBA trial session starting now @syctong @Josh_S_Davis@ABsteward
Staph aureus causes 1 million deaths per year worldwide. Less than 4.5k randomized in staph aureus bacteremia. Randomized care is better than random care. SNAP platform started on a napkin. #ESCMIDGlobal
@LiangRhea That line genuinely helps. For all intents and purposes I dressed as I would have done on a normal clinical day, just picked my nice outfit.
BREAKING: France's far-right National Rally (RN) party has been beaten into third place in France's parliamentary election, according to exit polls from BFM.
Sky's Europe correspondent @adamparsons says this is 'an absolute shock.'
Latest: https://t.co/uS5K3cAYyT
📺 Sky 501
The national service nonsense does give me the opportunity to tweet one of my favourite recent bits of polling when Ipsos actually ran the famous "Yes Minister" questions as a randomised experiment, and showed that it worked.
🧵 1/ What’s at stake with race-based equations for lung function? Clinical, occupational, and financial reclassifications for millions of patients.
I’m delighted to share this labor of love, published today in @NEJM and unveiled at #ATS2024.
https://t.co/9V0Bck071g
Very pleased to see a positive step here; however, boggles that other disciplines such as physios and med students have not been included. Our students show up, work, and are excellent members of the team. They should not be made to do it for free.
https://t.co/AqUCWq3dO4
Nothing portends the collapse of society quite as much as the way people stand right next to the baggage carousel at airports when their bags are nowhere in sight.
@PeterDTAdams @realCarrickRyan It’s also worth noting that this is much less than the 170K that Google gives.
(And also worth thanking you for highlighting that students are not paid on placement but ought to be!).
@PeterDTAdams @realCarrickRyan May assist with this discussion to know that junior doctors’ wages in each state are set by an enterprise bargaining agreement, not the award (which you’ve referenced here). Interns make about double what’s in the award + overtime. Most make about 100K
https://t.co/j2ZWT8blJ3
26/26 Small things like these by Claire Keegan. Rounding out the Keegans, and rounding out the reading challenge, this short story sees a fundamentally ordinary man grapple with the horror of Magdalen laundries. It’s quietly excellent
Another year another reading list. This year will be a busier one at and outside of work, but I’m determined to keep to a goal of 26 books read. Keep me honest below!