Trotman Lab

Cancer Genetics

[Bianca Jones Marlin, PhD @bjmarlin]

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[Bianca Jones Marlin, PhD @bjmarlin]

To Black Academics,
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[Cold Spring Harbor Laboratory @CSHL]

CSHL Cancer Center Director David Tuveson was chosen President-Elect of @AACR: “AACR’s mission is to improve the lives of people world-wide... Collectively we can solve the hardest problems and help the most cancer patients.”
https://t.co/IvI3P1A1lL

[Takahiro Maeda @TMHemOnc]

We are recruiting post-docs and technicians in our lab at the newly-established Precision Medicine Division at Kyushu University (no website yet!). We are looking for enthusiastic, self-motivated individuals who can interact well with others as part of a team! Plz RT.

[Trotman Lab @trotmanlab]

I agree, and the solution is key to our survival: more money for research and education. Fortunately, it’s an election year and we’ll all be fighting the good fight, right?

[Magdalena Skipper @Magda_Skipper]

History is a great teacher; we should pay more attention so we don’t repeat the mistakes made during the 1918 flu pandemic; some very poignant graphs in this @NatGeo story #COVID2019 #CoronavirusPandemic https://t.co/DsRjduUIkl

[Trotman Lab @trotmanlab]

Awesome NYT ‚Exposé’ with mugshots of the Coronavirus proteins that are harmless to bats and lethal to us. https://t.co/rkKwAh9rBv

[Dr. Glaucomflecken @DGlaucomflecken]

I swear to god if the cure for COVID-19 ends up having something to do with the Krebs cycle I'm gonna fucking lose it

[Trotman Lab @trotmanlab]

Intriguing new role for LKB1 in preventing squamous PC, the most lethal type of prostate cancer. Happy to have written a JEM Insight on the emerging concept with Grinu.
https://t.co/ioIyld5VVy
https://t.co/oo6oyJqXGI

[Trotman Lab @trotmanlab]

@MarkJHandley You did amazing work to help prevent even more damage! Your early analysis was key to closing local schools in our NY area at a time when everyone was focused on testing and Italy.

[Trotman Lab @trotmanlab]

Disease carriers vs those with symptoms impressively captured in Iceland vs. Netherlands.

[alexandre afonso @alexandreafonso]

Here is a distribution of recorded Covid-19 cases in Iceland (which tests broadly, even people with no symptoms) and the Netherlands (which tests narrowly, only those with severe symptoms)

[Trotman Lab @trotmanlab]

Excellent discussion of the gender distribtution of #COVID19 and potential link to androgens/ TMPRSS2.

[Rafael Fonseca MD 🦔🇺🇸🏜🇲🇽 @Rfonsi1]

*** COVID19 and males***
Is infection with SARS-CoV-2 more virulent among males, and if so why? Can we do anything about it, or use this information for treatment purposes. This thread is a compilation of thoughts & ideas by various colleagues: @AlanBryce9 & @lbaughn
#COVID19
1/x

[Trotman Lab @trotmanlab]

@HaigisLab Brain Child and Brain Games. Take care! L

[Trotman Lab @trotmanlab]

50 lines that tell our story. Research is the antidote.

[Trotman Lab @trotmanlab]

Does anybody know about emerging clinical data on Covid impact on men that are on anti-androgens versus not?

[Trotman Lab @trotmanlab]

Amazing data on gender differences. TMPRSS2 is essential for CoV-2 entry. Its levels may be higher in lungs of men. https://t.co/PMy1PhSDUB

[William K. Oh MD @WilliamOhMD]

The gender difference is striking. Is androgen signaling important?

[Nima Sharifi @NimaSharifiMD]

Not subtle: “FOXA1 was the most highly mutated gene in our Chinese cohort (41%). By contrast, FOXA1 was mutated in only 4% of TCGA prostate cancer and in 8–9% of primary prostate cancer and 12–13% of metastatic prostate cancer” ⁦@nature https://t.co/2dHCIScGzf

[Takahiro Maeda @TMHemOnc]

@ScienceMagazine @GaviSeth @gavi I am a bit shocked by this tweet by Science…
An ideal scientific collaboration should be “without” terrible implications for humanity...

[Kevan Shokat @kevansf]

#NoMTA_Required

[Trotman Lab @trotmanlab]

Literally sickening. Which other democracy puts up with this kind of opposite of a leader?

[Trotman Lab @trotmanlab]

@NimaSharifiMD What do you think about including DHT in lung cell culture experiments with COVID-2?

[Trotman Lab @trotmanlab]

Would definitely be worth testing. Unfortunately, if I remember discussion with @NimaSharifiMD correctly, mouse does not show the androgen levels seen in human lung, so would be a bad model- but I may be wrong here...

[William K. Oh MD @WilliamOhMD]

Would AR targeted therapies work here, @trotmanlab?