tryptaseplace

[Jesse Morse, M.D. @DrJesseMorse]

Another vaccine failure!

This time it’s Merck hit with a $50M settlement they’ve agreed to pay out as a result of their Gardasil HPV vaccine causing premature menopause, seizures, POTS, POI and other autoimmune disorders.

I’m glad they were held accountable!

[tryptaseplace @tryptaseplace]

@SethSHowes 1 in 20 Americans carries hereditary alpha-tryptasemia — a genetic variant linked to treatment-resistant ADHD, POTS, hypermobility, chronic inflammation, and early cardiac death across generations.

It requires a simple blood test to screen for. It is almost never ordered.

[tryptaseplace @tryptaseplace]

@SethSHowes This is exactly the energy we need. At-home genome sequencing today. At-home TPSAB1 copy number analysis tomorrow.

The lab is coming to the people. The diagnostic gap is closing whether medicine is ready or not.

[Adam Urato, MD @AdamUrato1]

NEW Study: SSRIs are associated with ⬆️bleeding risk -especially intracranial hemorrhage & GI bleeding- after percutaneous coronary intervention (PCI).
https://t.co/TFE1PXRreB

[Dr. Satish Raj’s Research Team @TeamSRRaj]

With the link below, you can get further details on Raj Lab MSc graduate Jaiden Uppal's paper: "A Randomized Crossover Trial of Ivabradine, Propranolol, and Placebo in Postural Orthostatic Tachycardia Syndrome: A Detailed Description" https://t.co/GG0WeLX0PB

[tryptaseplace @tryptaseplace]

@NIH_Innovates @NIH @NIHFunding No animal models needed. Real-world data. Genetically identifiable population. Immediately actionable.
This is exactly what NAMs research looks like in practice.
🔗 https://t.co/wVZLg4cxsP
#HαT #NIHAM #NAMs #HighlightedTopic43 #MAHA #FindTheThread

[tryptaseplace @tryptaseplace]

@NIH_Innovates @NIH @NIHFunding The Sentinel Initiative is a human-based platform trial using existing approved drugs in confirmed HαT patients.

[Valerie Anne Smith @ValerieAnne1970]

RFK Jr: "GROUNDbreaking HISTORIC WIN for American Health!"

"For the 1st time in history, doctors will finally get PAID to take patients OFF unnecessary medications...to DEPRESCRIBE harmful pharmaceuticals."

No more rewarding over-medication. This is the beginning of putting patients first, reversing polypharmacy, and delivering true healing.

Wellness over pills. Freedom over dependency.

[tryptaseplace @tryptaseplace]

@NEJM $50 test. Never ordered.
🔗 https://t.co/wVZLg4cxsP
#HαT #InflammatoryMyopathy #Rheumatology #MAHA #FindTheThread

[tryptaseplace @tryptaseplace]

@NEJM @NEJM
Inflammatory myopathies published today.
One question worth adding to the workup:
Was basal serum tryptase measured?
🧵

[tryptaseplace @tryptaseplace]

@NEJM 1 in 20 patients carry HαT — constitutively elevated tryptase continuously degrading connective tissue and fascia via MMP activation.
Treatment-resistant inflammatory myopathy in an HαT carrier may not respond to immunosuppression.
Because the upstream driver was never identified

[HHS Rapid Response @HHSResponse]

“We are going to turn off the money”

🚨 BREAKING: @VP announces that @WHFraudTF is requiring all state Medicaid programs to show they are aggressively prosecuting fraud.

[tryptaseplace @tryptaseplace]

NIH found the hardware. We found the software bug.
1 in 20 have perfect islets but still get diabetes.
HαT: extra tryptase → mast cells on fire → insulin signaling broken.
https://t.co/wVZLg4cxsP #HαT

[NIH @NIH]

NEWS: An NIH-funded research team has uncovered new clues about diabetes risk and the genetic and cellular factors that contribute to it.

Read more ➡️ https://t.co/dxORU6y5wn

[tryptaseplace @tryptaseplace]

@NIH Adding BST to the IIDP donor registry costs under $50 per donor.
It would tell you whether the residual variance in your model has a genetic explanation hiding in plain sight.
We published the research. 38 gaps. OSF timestamped.
🔗 https://t.co/wVZLg4cxsP

#HαT #Diabetes

[tryptaseplace @tryptaseplace]

@NIH IL-6 and TNF-α are already confirmed early biomarkers in gestational diabetes.
In HαT carriers they’re not a response to metabolic stress.
They’re the baseline. The outliers in your dataset — those whose diabetes risk doesn’t match their islet composition — may carry HαT.

[Adam Urato, MD @AdamUrato1]

FDA must warn the public.

With this new study, there are now 13 -yes 13- consecutive MRI studies showing that SSRIs alter fetal brain development. (Listed below)

There is scientific agreement. Common sense, basic science, & animal/human studies all show this.

The Studies:
#1 Wu, Y., Andescavage, N., Wisner, K. L., Kapse, K., Murnick, J., Ngwa, J. S., & Limperopoulos, C. (2026). Prenatal serotonin reuptake inhibitor exposure and maternal depression symptoms are associated with altered fetal brain and placental development. Neuropsychopharmacology. https://t.co/GBZb3M28Ti

#2 Zanni, G, et al (2025). Perinatal SSRI exposure impacts innate fear circuit activation and behavior in mice and humans. Nature Communications, 16(1), 4002. https://t.co/CxSMGEdHla

#3 Koc, D., et al (2023). Prenatal antidepressant exposure and offspring brain morphologic trajectory. JAMA Psychiatry, 80(12), 1208–1217. https://t.co/jk076qyza3

#4 Moreau, A. L., et al (2023). Biological Psychiatry: Global Open Science, 3(2), 243–254. https://t.co/a0uFWgAjs9

#5 Campbell, K. S. J., et al (2021a). Prenatal antidepressant exposure and sex differences in neonatal corpus callosum microstructure. Developmental Psychobiology, 63(6), e22125. https://t.co/7r2kKdKHNg

#6 Salzwedel, A., et al (2020). Functional dissection of prenatal drug effects on baby brain and behavioral development. Human Brain Mapping, 41(15), 4123–4135. https://t.co/WwJ9OVpSfp

#7 Rotem-Kohavi, N., et al (2019a). Hub distribution of the brain functional networks of newborns prenatally exposed to maternal depression and SSRI antidepressants. Depression and Anxiety, 36(8), 753–765. https://t.co/dUmhzy7Dr1

#8 Rotem-Kohavi, N., et al (2019b). Alterations in resting-state networks following in utero selective serotonin reuptake inhibitor exposure in the neonatal brain. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 4(1), 39–49. https://t.co/oxavYacorN

#9 Lugo-Candelas, C., et al (2018). Associations between brain structure and connectivity in infants and exposure to selective serotonin reuptake inhibitors during pregnancy. JAMA Pediatrics, 172(6), 525–533. https://t.co/yrZsh2PTGI

#10 Podrebarac, S. K., et al (2017). Antenatal exposure to antidepressants is associated with altered brain development in very preterm-born neonates. Neuroscience, 342, 252–262. https://t.co/6JqtBfcZ8x

#11 Jha, S. C., et al (2016). Antenatal depression, treatment with selective serotonin reuptake inhibitors, and neonatal brain structure: A propensity-matched cohort study. Psychiatry Research: Neuroimaging, 253, 43–53. https://t.co/ssy8vEUKR1

#12 Salzwedel, A. P., et al (2016). Thalamocortical functional connectivity and behavioral disruptions in neonates with prenatal cocaine exposure. Neurotoxicology and Teratology, 56, 16–25. https://t.co/lM31RBLIEY

#13 Knickmeyer, R. C., et al (2014). Rate of Chiari I malformation in children of mothers with depression with and without prenatal SSRI exposure. Neuropsychopharmacology, 39(11), 2611–2621. https://t.co/py7FszONmh