Valentin L'Hôte

🧑‍🔬 MSCA Postdoc @UmeaUniversity @Wanrooij20 Lab
🧬 mtDNA replication and dynamics in health, senescence and cancer
📕 PhD from @UnivParisSaclay

[Valentin L'Hôte @val_lhote]

In our new review @RSocPublishing from the Mann/Thuret lab @UnivParisSaclay @CEA_Officiel @I2BCParisSaclay we propose a classification of #senolytics based on their mechanisms of action, and discuss their selectivity in different types of #senescent cells: https://t.co/3OzSD8QUlD

[Sholto David @addictedtoigno1]

Surprised to discover that Thermo Fisher appears to show a fake western blot for the validation of one of their p53 antibodies. I've added a diagram to show the very similar bands. This does not appear to be one of the "published figures", but their own internal data.

[MITOtalks @MitOtalks]

The MITOscience of tomorrow is back. Three short mitochats presented by
Débora Santos Rocha @usponline @helmholtz_diabc ,
Valentin L’Hôte @val_lhote and
Marijana Croon @MarijanaCroon
Visit https://t.co/3L1pgw0rt8 for zoom link details.
Will you time travel with us?

[yICSA @YicsaC]

Highlights from yICSA at #ICSA2025Rome 🌍✨ ✔️Networking Social Event 🤝
✔️Special Session with career insights from
@DiMiccoLab & @narita_lab
🙌 Thank you to everyone who joined us! #yICSA #Senescence #ECR

[Valentin L'Hôte @val_lhote]

I had a great time presenting my work on mtDNA replication and senescence from the @Wanrooij20 lab
@umeauniversity today at the #ICSA2025Rome conference, with super exciting discussions. Thanks a lot @ICSA_senescence and @YicsaC!

[Valentin L'Hôte @val_lhote]

On a road trip from Umeå (SE) to Rokua (FI) to attend the #Mitochondria Summer School this week!

[Valentin L'Hôte @val_lhote]

Amazing to be back at @UnivLaRochelle today to talk about #mtDNA, #senescence and #cancer at @LIENSsCNRSULR and have exciting discussions! Going back to Sweden tomorrow, but I hope to return to La Rochelle soon.

[International Cell Senescence Association @ICSA_senescence]

Save the date! @marc_dema announced that the next ICSA meeting will be held in Rome, marking the 10th anniversary of the ICSA meetings. Get ready for #ICSARome2025! 🇮🇹

[Valentin L'Hôte @val_lhote]

@jclandoni @NatureComms @AWartiovaara @seminerkul @JMitophile @Kivela_lab @WickstromLab Well done Juan!! I will read it soon 😁

[Baris Olivier @BarisOlivier]

More to come soon...

[Sjoerd Wanrooij @Wanrooij20]

From our lab: The POLγ Y951N Mutation, disrupts the Key Switch Between DNA Synthesis and Proofreading, Triggering Mitochondrial DNA Instability https://t.co/nxgTYrwWM3

[Freed Assange - #FreeAssange @FreeAssangeNews]

JULIAN ASSANGE IS FREE

[Science Magazine @ScienceMagazine]

Begin universe.
Wait three minutes to enter.
Stay cool. Don't react.

What's your favorite element haiku? Discover your answer on #WorldPoetryDay. ⬇️ https://t.co/sHHcjiKsYz #ChemHaiku

[Sjoerd Wanrooij @Wanrooij20]

Exciting collaboration with the Erik Chorell lab!
G4-Ligand-Conjugated Oligonucleotides Mediate Selective Binding and Stabilization of Individual G4 DNA Structures | Journal of the American Chemical Society https://t.co/Xt7YGXGP6U

[Alexis Lomakin, Ph.D. (אל) אַלעקסיס לאָמאַקין @Alexis_Lomakin]

‼️Important review discussing cellular senescence/Sen reversibility; the outdated state of Hayflick-Moorhead's definition of Sen; existence of cells in a Sen-like phenotype that can be a hybrid b/w quiescence, hibernation & diapause; semantics issues,etc.
https://t.co/Hy69i4yh23

[Valentin L'Hôte @val_lhote]

I am thrilled to be awarded an #MSCA Postdoctoral Fellowship to characterize and target new mechanisms by which #mitochondria regulate cellular #senescence in the lab of Sjoerd Wanrooij @Wanrooij20 at @umeauniversity. Very grateful to @MSCActions!

[KAW @KAWstiftelsen]

Article: Enhanced mitochondrial G-quadruplex formation impedes replication fork progression leading to mtDNA loss in human cells #Research supported by Knut and Alice Wallenberg Foundation #KAW100 #DNA
#mitochondria #biophysics @OUPAcademic
https://t.co/jHSGIQo6Fd

[Valentin L'Hôte @val_lhote]

In our latest study led by Mara Doimo in the @Wanrooij20 lab, we show that #mitochondria DNA replication stalling increases #GQuadruplex formation, and that stabilizing G4s blocks mitochondrial replication fork progression and leads to #mtDNA depletion https://t.co/NokBFbRBtP

[Sjoerd Wanrooij @Wanrooij20]

The latest from our lab! Great work from Mara Doimo.
https://t.co/guICWc7R4e

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

From the divergence of senescent cell fates to mechanisms and selectivity of senolytic drugs

https://t.co/ArWJNMFeSl