Vamsi Mootha

physician-scientist studying mitochondria, oxygen, bioenergetics Tweets = my own

[Vamsi Mootha @VamsiMootha]

Today, the MitoCarta Tree of Life Consortium (MitoTOL) is releasing high-accuracy mitochondrial proteomes across diverse eukaryotes to empower studies of physiology, evolution, and disease:

https://t.co/hRt6ZG4lQP

All data can be accessed at:

https://t.co/oPFODZBQ60

[Jay Bradner, M.D. @jaybradner]

Jon Clardy was a brilliant scholar and a wonderful man, beloved uniformly in chemistry and chemical biology from Boston to Brazil. My sincerest condolences to those who were lucky to know him well, as mentees and close friends. RIP, Jon, just cannot believe you are gone.

[Michael Fischbach @mfgrp]

Jon Clardy: 1943-2026
One of the most impactful, creative, and (quietly) irreverent practitioners of chemical biology. Transformed how we think about nature's chemicals: their structures, their role in biology. Loved him -- he had tremendous influence on my thinking.

[Ankit Gupta @agupta]

Cambridge has always been the best place in the world to be an academic researcher. These days, a lot of cutting edge research also happens in industry, and Cambridge is the home to many amazing research startups, spanning AI research, robotics, biotech, defense, and industrials.

We'd love for these two worlds to meet eachother, so we're bringing YC Paper Club to Cambridge!

if you're a researcher in industry or academia, request a spot below.

[nature @Nature]

Scientists have mapped in unprecedented detail the proteins that make up the mitochondria in six organisms spanning the eukaryotic tree of life

https://t.co/9YfQZBU01v

[Vamsi Mootha @VamsiMootha]

Introducing our next-gen “hypoxia in a pill” - we upgrade the combo by replacing GBT440 w/ 2nd-gen Hb affinity enhancer GBT601, and continue to pair with HIF-2α inhibitor PT2399. Highly effective in advanced Parkinson’s dz and Leigh syndrome mouse models
https://t.co/58KbrX4s1p

[Broad Institute @broadinstitute]

A new study led by @VamsiMootha shows that a newly optimized hypoxia-inducing drug combination greatly improved symptoms of neurodegeneration in mouse models of rare mitochondrial disease as well as a model of Parkinson’s disease. https://t.co/UvVkFSkDNM

[Vamsi Mootha @VamsiMootha]

So proud to see @rahulg603 receiving this recognition! His work on mitonuclear genetic variation across nearly 1M humans is revealing deep insights into disease and aging. The future of biomedicine is bright! @broadinstitute @MassGeneralNews

[Rahul Gupta @rahulg603]

So excited to be selected one of STAT’s 2026 Wunderkinds. Huge thanks to my PhD advisors @VamsiMootha & Ben Neale + all my incredible mentors & colleagues. It's a huge honor to be in this inspiring cohort of scholars! @statnews #STATWunderkinds

[Alex Rives @alexrives]

A universal predictive model of the cell would dramatically accelerate science, allowing biologists to perform experiments digitally. Today we’re announcing a major partnership with the DOE and NIH. The goal of this partnership is to generate the data that will be needed to build an accurate model of the cell with artificial intelligence.

Isomorphic, Google DeepMind, and Meta are joining us as founding partners in the Virtual Biology Initiative. This is the beginning of a large scale coordinated effort to map cellular biology to power the development of digital models of life. Other leading scientific institutions and consortia including the Allen Institute, Broad Institute, Gladstone Institutes, the Human Cell Atlas, the Human Protein Atlas, the Wellcome Sanger Institute, as well as NVIDIA, are working together as part of this international scientific project.

Creating a predictive model of the cell is one of the most important challenges for the next decade of science. The insights that come from this could unlock a far greater understanding of disease, and open new paths for cures.

We invite the worldwide scientific community and other funders to join us in this effort.

[Cell Press @CellPressNews]

A new collection from the MitoCarta Tree of Life consortium is out in @CellCellPress, @CurrentBiology, @MolecularCell, and @cellpressblue representing a milestone toward a comprehensive atlas of mitochondrial proteins across diverse eukaryotic species. 
https://t.co/DJdReu2F4V

[Cell @CellCellPress]

In the latest issue! Mitochondria before we knew them dlvr.​it/TVpBDv

[Cell @CellCellPress]

In the latest issue! Acanthamoeba ATP synthase structure reveals the TCA cycle is tethered to OXPHOS dlvr.​it/TVnFJS

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The 2026 #NobelPrize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”

[Medical Xpress @medical_xpress]

33 protein families shared by multiple parasites could be drug targets; none occur in human mitochondria, offering candidates for treatments against more than one disease. @CellCellPress @currentbiology @MolecularCell https://t.co/dXNIT34E9u

[Tennis TV @TennisTV]

JAW-DROPPING 🤯

@DjokerNole @AlexZverev #ChinaOpen

[Alice Ting @aliceyting]

Remarkable Magnum Opus from @VamsiMootha & the Mitocarta Tree of Life consortium consisting of 9 back to back research papers (+2 perspectives) just released in Cell and Cell family journals:

- Characterization of mito proteomes from 6 diverse species, from Giardia to Leishmania to Arabidopsis
- Optimized methods for mito enrichment, DIA mass spec, protein correlation profiling, microscopy validation, and cryoEM analysis of native complexes
- Comparative analysis reveals dozens of proteins shared among pathogens but lost in human hosts = “pan-parasite” drug targets
- Data used to re-train ML predictor of subcellular localization => predicted mitoproteomes across hundreds of eukaryotes
- Giardia solute carrier discovered with functional validation
- Dynamic rewiring of Acanthamoeba mito proteome from aerobic to anaerobic energy production characterized

And tons more… The papers are instant landmarks and raise even more questions than they answer, paving the way for many future investigations of this fascinating organelle #mitochondria

https://t.co/yjUnnh6CI3

[Genetic Engineering & Biotechnology News @GENbio]

Proteomics Maps Eye-Infecting Acanthamoeba Mitochondria Across Oxygen Levels

The Acanthamoeba mitoproteome was mapped, revealing oxygen-driven metabolic shifts and potential targets for safer infection treatments
@jastefely @VamsiMootha
#proteomics
https://t.co/vYy3Ujo7pX

[Nathaniel David @NathanielEDavid]

I (fondly) remember as a TA insisting Berkeley undergrads memorize the Krebs cycle and OxPhos ('it's good for your soul,' id say). We'd draw the Krebs cycle as a loop floating free in the mitochondrion, and the respiratory chain as a separate machine in the membrane. In one organism they are bolted together.@VamsiMootha

https://t.co/8vjO6r2RZz

[Michael Zhu Chen @michaelzhuchen]

Proud to share the fruits of a 4 year effort with an amazing team at the MitoCarta Tree of Life Consortium! Today, we report insights on the origin and evolution of mitochondrial proteomes across billions of years: https://t.co/3iaZWTejSS
https://t.co/eQCeNUqotj

[Jonathan Stefely, MD, PhD @jastefely]

Our paper on a new genome annotation for the pathogen Acanthamoeba castellanii is now online at @cellpressblue! https://t.co/09a4u5Dbm4. This was a key foundation for our separate AcMitoCarta paper. Grateful to John Samuelson and @VamsiMootha for their mentorship!

[Jonathan Stefely, MD, PhD @jastefely]

Our paper "Mitochondrial proteome of Acanthamoeba delineates aerobic and anaerobic pathways dynamically regulated by oxygen" is online now @CellCellPress! https://t.co/NPjdwdwcHD. Grateful to my amazing post-doc mentor @VamsiMootha and all the other team members!