it's live. two years of tracking peptides in a notes app and pure vibes, so i built the thing i wanted. log your protocol, see what's active in your blood, keep bloodwork in one place. PepVault is on the App Store today. logging's free, forever.
Orforglipron could end the era of peptide injections.
Phase 3 data shows people who switched off Ozempic or Mounjaro onto orforglipron kept 75-79% of their weight loss.
Here's the breakdown: (1/9)
@DrKERMD worth tempering hope: BPC/TB/KPV are the same ones FDA shuffled into the hard-to-characterize bucket in '23 over immunogenicity. a review date is real progress, but the bar's been high - watch, not a done deal.
@peptidedaily_ it also fades fast as the receptor desensitizes - usually a week or two, so don't quit on day 3. and shooting it before bed vs pre-meal lets the worst pass while you sleep.
@episurveillanc that 3.5-4 jump is right where reta's GI load tips for a lot of people - your body basically told you your dose lived under 4mg. the microdose window was your sweet spot, not the climb.
@SubtleInduction@richtrades100 it's not reta-but-worse - those duals are a fatty-liver bet, not a weight one. glucagon torching liver fat is the point, and ditching GIP is on purpose. whole different target.
@DailyPeptide oral sema needs an absorption enhancer + ~10x the dose to match a fraction of the shot - the gut eats the rest. for most peptides that math just doesn't pencil yet, so the vial stays.
@mrjavascript@BowTiedYukon bpc is literally a fragment of a protein already sitting in your gut, but sure, the toad's the safe bet. the risk assessment in this space is really something.
@ironveicleo@Skyler_Tea this is honestly the blueprint - most of the brutal sides people post are just dose-driven, so going low lets your gut keep up. and the protein + walking is what keeps the loss lean, not skinny-fat.
so i'm on tirzepatide microdose, i do low doses, i eat healthy, take my vitamins and proteins and i walk daily and exercise 3-4x a week, with this i was able to achieve my weight goals, and i didn't have any wild side effects like those we see online
i realized dosage really matters and i probably wouldn't feel the same if i went straight into full dose, so that's why i'm following @Aurelius_Health protocols and their way of glp1 microdosing and it is so worth it
@drmarlonperalta the glucagon arm is why reta does this and tirz/sema can't - cranks expenditure + blunts fat storage at once. point 2's the catch though: the carb abuse only holds if you're training hard enough to demand it.
@TheCryptoDaddi titrate-down holds better imo - ramping up then cliffing just makes the rebound hit all at once. the slow taper buys time to lock in the food habits, and that's the part that actually holds.
@undefinedKi been running my own version of this for months and what bit me wasn't the setup, it was bloat - a brain that just keeps getting bigger slowly gets dumber. how do you keep the vault from rotting once it's actually huge?
@vitall_UK the oral route is the real unlock - the needle is a bigger barrier than people admit, especially for first-timers. an effective tablet widens the top of the funnel way more than another injectable could.
@eitchan@IntegralAnswers 70kg on the oral version is a staggering case. at a 300kg start the runway is huge, but most assume the tablet underperforms the shot - cases like this are why the oral approvals matter so much for access.