Viviana Macarelli

Postdoc at @Stanford and @CZI 🔬

Characterising neuronal primary cilia using stem cell-derived neurons 🧪

[Viviana Macarelli @VMacarelli]

Thrilled to finally share our review where we dive into the mechanisms regulating the length of primary cilia in neurons and how this phenomenon might influence cellular signalling!

You can access the full article here: https://t.co/R5m3uLezdu

@FlorianMerkle

[Trends Cell Biology @TrendsCellBio]

Regulation of the length of neuronal primary cilia and its potential effects on signalling https://t.co/qUPlODLFfr

[Florian T. Merkle PhD, Bluesky: @florianmerkle @FlorianMerkle]

I'm excited to share our latest pre-print on proximity proteomics of primary cilia in human hypothalamic neurons, led by @VMacarelli, which revealed proteins involved in synapses and neurotransmission and the obesity-associated GPCR LPAR1. Details at https://t.co/LdVSjbvuOu

[Viviana Macarelli @VMacarelli]

Happy to share our Science & Society article just published in @TrendsCellBio! We reflected on the value of joint peer review between early career researchers and mentors and you can read it here:
https://t.co/lZfsgYo5KW

[Viviana Macarelli @VMacarelli]

Excited to finally read this!

[Mick lab @MickLab]

Proud to share our work by a fantastic team, spear-headed by PhD student @Kainerox with major contributions by #xenopus expert @RosiFeistel.

We developed an improved iAPEX-based #ProximityLabeling method for #massspec based subcellular #proteomics.

https://t.co/0jDlrlkK7M

[Viviana Macarelli @VMacarelli]

Thank you so much @TanosBarbara and @MennellaLab for being the examiners at my PhD defense! It was great to have the chance to discuss my PhD project with you!

[Barbara Tanos @TanosBarbara]

Congratulations Viviana! @VMacarelli @FlorianMerkle @Cambridge_Uni
Great excuse to get together with some cilia peeps. We are missing a picture here… hopefully we can do that soon!

[Viviana Macarelli @VMacarelli]

Even if attending online, I had a great time listening to all the amazing talks! And thanks to the organisers for printing and putting up my poster anyway! Looking forward to the next meeting!
@EuroCilia2024

[Viviana Macarelli @VMacarelli]

Amazing tool!

[Oktay I. Kaplan @KaplanOLab]

Our paper "CilioGenics: an integrated method and database for predicting novel ciliary genes" is out in @NAR_Open !

https://t.co/h4AQjwJiRi

A preprint of this work was posted in April 2023.

[Viviana Macarelli @VMacarelli]

3. We generated stable hiPSC lines expressing a membrane construct with or without the successful targeting sequence.

This has been a big part of my PhD project and we hope these resources will be useful for the cilia community!

[Viviana Macarelli @VMacarelli]

1. We reviewed the literature for motifs described as sufficient for proteins localisation to primary cilia

2. We used these sequences to generate cytoplasmic and membrane-localised reporter constructs and tested their ability to target primary cilia of hIPSC-derived neurons

[Viviana Macarelli @VMacarelli]

@csenge_rezi @emboreports Congratulations!! 🎉

[Reiter Lab @ReiterLab]

Please read, send feedback and retweet link to free full-text work on how a variant cell cycle coordinates differentiation of multi ciliated cells: https://t.co/k6XhildO0R

[Viviana Macarelli @VMacarelli]

Had an amazing time at #FASEBCilia2024 and had the chance to meet amazing people!!

[HHMI | Janelia @HHMIJanelia]

New research led by Carolyn Ott, a senior scientist @JLS_Lab, provides the most detailed & comprehensive description yet of cilia in the mouse visual cortex, giving scientists new insights into the formation & function of this small & elusive organelle.
🔗https://t.co/HAIyr7d7V5

[Kateřina Apolínová @apolinovak]

Excited to share that my PhD project has been published in @FrontCellDevBio! Introducing the ZebraReg platform. Hoping our work at @ZeClinics & @nmercaderh lab paves the way for new therapies to combat heart attacks in humans. 🐟 ❤️@scils_eu @ZebrafishRock https://t.co/YJ87vPG6wN

[Søren T. Christensen @t_soren]

1.our latest preprint on ciliary TAK1 signaling in heart development and syndromic CHD co-led by the Larsen (@LarsAllanLarsen) and Christensen (@s_tvorup) labs. https://t.co/7MY1CgwUkM

[Viviana Macarelli @VMacarelli]

Thrilled to share our recent preprint where we explore ciliary targeting sequences in hIPSC-derived neurons @FlorianMerkle @EdwardCHarding https://t.co/P7jFe0DHPv

[Inst Metabolic Science-Metabolic Research Labs @IMS_MRL]

🤞🤞🤞Best of luck to PhD student @VMacarelli from @IMS_MRL who is taking part in #STEMforBritain today! #stem4brit presenting her poster on 'THE ROLE OF PRIMARY CILIA IN METABOLIC SENSING IN HYPOTHALAMIC NEURONS'

[Viviana Macarelli @VMacarelli]

@MickLab Thank you!! 🤩

[Viviana Macarelli @VMacarelli]

Had an amazing time at the #UKCilia2023 meeting, talking about #primarycilia and connecting with many new fantastic people!

[Viviana Macarelli @VMacarelli]

@Mill_lab @FlorianMerkle Thank you! And thank you for this opportunity and organizing this amazing meeting! 😍

[Viviana Macarelli @VMacarelli]

Can't wait to be there!

[Florian T. Merkle PhD, Bluesky: @florianmerkle @FlorianMerkle]

This looks like a fantastic meeting, where @VMacarelli, a talented PhD student from my team, will be presenting our disovery of a compact sequence that targets proteins to primary cilia in all ciliated cell lines we've tested so far, including human neurons. RT and apply!