We updated our work with more data!
Histology and in vitro studies giving us evidence of direct action of metformin in the brain at physiological concentrations
@IMS_MRL@FlorianMerkle
"Dendritic arborization decreased during torpor in V1..."
".... fully reversed during intertorpor arousal, indicating that on average dendritic arbors grew by 0.75 mm (65%) over ∼1.5 h"
That's fast!
Such a shame this is happening. It used to be quite good. Within fields where strong labs were similarly active in reviewing. And (people forget) reviewers named on every article.
The automated assignment and constant emails, with your signature, was always its weakness.
I’ve officially resigned as Associate Editor for Frontiers in Systems Neuroscience (part of @FrontNeurosci). It used to be a reputable journal, but became a case study in how forced automation destroys academic integrity. 👇
MOSAIC – an optical microscope that achieves super res across scale & depth in living tissue
📹 Tian-Ming Fu, Gaoxiang Liu, Daniel E. Milkie and Xiongtao Ruan et al @HHMIJanelia@UCBerkeley in @naturemethods
➡️ https://t.co/ITrxfdWwXx
Between 1985--2023, MIT's faculty grew 9%. Administrative staff grew 189%. 📈 Why? In new @PNASNews paper, we use dynamical system model to show administrative bloat can emerge without empire-building--just from well-intentioned problem-solving gone awry https://t.co/MZgGkxilZ2
Limited transmission of cervid prions to nonhuman primates provides insights into the zoonotic potential of chronic wasting disease. My take - Possible limited replication of cwd prions in primates, not entirely ruled out persistence of inoculation. https://t.co/N3MhugAF1M
Absolutley. This is a huge inefficiency in the field. Realistically means complex studies take years, when maybe they didn't need to.
Not even mentioning the tech trend to ever more complex surgery.
There is a big elephant in the room in experimental systems neuroscience:
Before many trainees can test a single hypothesis, they spend 1–3 years becoming expert mouse surgeons rather than scientists.
Here's my proposal for how we can waste less time and do more research🧵
This is a superb clinicians review of CAA in NEJM, but in my opinion overlooks the fundamental that CAA is essentially a prion disorder with inherited sporadic and transmitted forms just like CJD. Important for public health to acknowledge this fact and its implications.
Update on a CRISPRi map of iPSC-microglia activation states with 31 regulators that bias cells toward disease-associated, interferon-response, or antigen-presenting programs. This is interesting because it turns "microglial state" from a descriptive label into a knob you can turn.
Highly relevant for anyone working on iPSC-derived brain therapies, where the host microglia decide whether your graft thrives.
https://t.co/PPjbZfQPZQ
Mesmerizing light sheet imaging of neutrophils swarming at a yeast target!
The neutrophils were labeled with SPY650-DNA (yellow) and a calcium dye (blue).
This movie is part of the recent manuscript by
Evelyn Strickland that we highly recommend reading! https://t.co/U6tn4sfogZ
The recent report by the Cochrane Collaboration concluded breakthrough Alzheimer’s drugs are ineffective and unlikely to benefit people living with the disease.
This has attracted widespread debate and some criticism from many in the dementia research community.
It is essential we challenge whether some of the conclusions reached in this report are an accurate representation of amyloid targeting therapies for Alzheimer’s disease today.
Here is what we, along with leading experts, have to say on the claims that anti-amyloid drugs are ineffective. 👇
https://t.co/tDBfFCuRwD
Anti-amyloid treatments like lecanemab and donanemab are not the whole answer. But it is just as wrong to dismiss their impact as ‘trivial’ as it is to overhype them. We heard from Dr Susan Kohlhaas, Executive Director of Research and Partnerships, to get to the facts behind today’s headlines.
After decades of research, we are finally seeing the first generation of treatments that prove we can slow dementia. They are not perfect and much more work is needed. But oversimplifying the hard-won progress made into “they don’t work” risks undermining public understanding, damaging trust and setting back momentum at a critical moment.
If you agree, please share this video.
https://t.co/gkobmrc5jh
@smead2 So much resistance to prion-like mechanisms! Framing dementia close to a prionopathy now seems to preclude any related funding. I just don't get it.
Nice paper from colleagues emphasising prion-like mechanisms in dementia and inclusion of CJD in funding mechanisms for dementia disorders. Surprising resistance to prion-like mechanisms in dementia communities which imo often stems from poor understanding https://t.co/Yt9YCTHsnz
How does blood flow relate to brain activity? We discovered that it reflects two neural populations affected oppositely by arousal. Together, they explain neurovascular coupling in all brain regions and brain states!
Out in Nature: https://t.co/wtjzmbIjmz
@UCLBrainScience