Georgios Voloudakis

Associate Professor, Departments of @MountSinaiPsych, @SinaiGenetics & @AIHealthMtSinai, @IcahnMountSinai
#VoloudakisLab @CDNeurogenomics

[ini_fadelli @Ini_fadelli]

Study explores link between people's professions and their genetic predisposition to neuropsychiatric traits
https://t.co/CX6Ts5wlHe

[Nature Human Behaviour @NatureHumBehav]

.@voloudakis et al. show statistically significant, but weak, associations between occupational categories and genetic risk scores for psychiatric disorders.
https://t.co/ZIOiqLvl11

[Center for Disease Neurogenomics @CDNeurogenomics]

🎉 Excited to announce preprints from the first #PsychAD package! Check out details of our work at https://t.co/BhkOaqATQV

🧵 Found out summary of papers below👇

[Georgios Voloudakis @voloudakis]

@doctorveera The journal has shared this SharedIt link to access the full version of the article for free: https://t.co/WhO5kYJ5bJ @doctorveera always a pleasure collaborating with you <3

[Veera Rajagopal  @doctorveera]

Association of polygenic scores for neuropsychiatric traits with self-reported professions based on analysis of 420k individuals from UK Biobank and Million Veteran Program. Look at the 'arts & design' category. Artistic talent comes at a cost--a piece of your mind :)

Voloudakis et al. Nat Hum Behav
https://t.co/99o4O12Tdk

[Veera Rajagopal  @doctorveera]

First GWAS of binge eating disorder using machine learning-based EHR phenotype @NatureGenet. One of the GWAS hits is hemochromatosis variant C282Y in HFE implicating iron metabolism in disease etiology. Congrats @panos_roussos @voloudakis and team.
https://t.co/lWRclIlD01

[Panos Roussos @panos_roussos]

And further discussed in a news and views article @NatureGenet by @jacksonthorp et al. https://t.co/L7hpziWkgM

[Panos Roussos @panos_roussos]

Excited to share the first GWAS of binge eating disorder using #MVP from @BursteinPhD TrevorGriffen @voloudakis at #CenterDiseaseNeurogenomics @MountSinaiPsych @SinaiGenetics @SinaiBrain @IcahnMountSinai that was published in @NatureGenet https://t.co/LqNI66pX4X

[Veera Rajagopal  @doctorveera]

New GWAS of ADHD based on 38,691 cases and >180k controls.
Congrats! @DemontisDitte, @AndersBorglum, @iPSYCHdk and collaborators. 🧵
https://t.co/EJllLmDb8X

[Veera Rajagopal  @doctorveera]

Phenotype misclassifications in the GWAS cohorts dilute effect sizes and reduce statistical power. Here the authors describe a statistical approach to quantify and adjust for effect size dilutions in GWAS meta-analysis. Interesting!
https://t.co/EPXeW4Pjqh

[Mount Sinai Psychiatry @MountSinaiPsych]

Its 6 groups:

Multi-omics Technology @FullardJohn
Multi-omics Data Integration @JaroslavBendl
Computational Neuroepigenomics @Kirangirdhar
Statistical Neurogenomics @g_e_hoffman
Single Cell Neurogenomics @hoondy
Translational Bioinformatics & Precision Therapeutics @voloudakis

[Mount Sinai Psychiatry @MountSinaiPsych]

The website for the Center for Disease #Neurogenomics is LIVE! Led by @panos_roussos, this is one of few centers in the world w access to brain tissue & population-level datasets.

Learn more: https://t.co/HiinNL7vJv

@SinaiBrain @IcahnMountSinai @IcahnInstitute @SinaiGenHealth

[Veera Rajagopal  @doctorveera]

Better late than never. Happy and relieved to share a final published version of one of my PhD projects in which we uncovered a fascinating genetic link between language ability, psychiatric risk and creativity. 🧵
https://t.co/n8lsZmhIw9

[Manuel Mattheisen @immaqua]

We would like to share with you our recently published article “Identification of shared and differentiating genetic risk for autism spectrum disorder, attention deficit hyperactivity disorder, and case subgroups.” https://t.co/bJL9oze8FO… Details below.

[Veera Rajagopal  @doctorveera]

Today @RegeneronDNA celebrates the publication of genetic discovery and functional validation of ANGPTL7 as a highly promising drug target for glaucoma.
https://t.co/wSqXeSmJS8

[Panos Roussos @panos_roussos]

Finally, congrats to @voloudakis for leading the collaboration with @AndersBorglum @immaqua and colleagues on the shared and differentiating genetic architecture for #Autism and #ADHD @NatureGenet https://t.co/BVVFTvL4YB

[Panos Roussos @panos_roussos]

Big congrats to #TimBigdeli @voloudakis and many other collaborators for the recent paper describing Penetrance and Pleiotropy of Polygenic Risk Scores for #Schizophrenia, #bipolardisorder , and #depression Among Veterans using the #MVP and #CSP572 cohorts

[Panos Roussos @panos_roussos]

Excited to share our #singlecell multi-cohort dissection of the transcriptome in #Schizophrenia https://t.co/zcDywB9x46 with @brad_ruzicka @ShahinMohammadi @FullardJohn @manoliskellis

[Anders Børglum @AndersBorglum]

I’m happy to share a preprint of our new GWAS of depression, identifying 64 new risk loci, refining the genetic architecture and predicting risk of recurrence and comorbidities.
https://t.co/bLU3wdLZvv

[Veera Rajagopal  @doctorveera]

The first GWAS of binge eating disorder identifies loci near HFE, MCHR2 and LRP11. At the HFE locus, one of the risk variants is the hemochromatosis variant thereby linking iron overload with bing eating (looks like the opposite of iron deficiency and pica). Fascinating!