The team at @10x_Science is delivering a huge unlock for drug development by increasing the speed of protein characterization by orders of magnitude. David, Andrew and Vishnu are an insanely talented team working on a huge problem! And they’re hiring.
We struggled to get monitors to catch reward hacking in agents... so we built a new lens. 🔭
Hodoscope allows you to visualize and audit agent trajectories at scale. Using it, we found a brand new vulnerability in commit0 in just minutes! ⚡️
We're excited to see what you uncover! Use Hodoscope to inspect your own agent trajectories and make your systems more robust. 🚀
.@10x_Science is the AI-native solution that pharma companies use to identify viable drug candidates faster, more accurately, and at scale.
Congrats on the launch @DSRoberts007, @vrtejus, and Andrew!
https://t.co/KNEdE2GZcd
I started my career as a theorist, and am now an empirical LLM researcher. In today's blog post, I talk about the parallels between theory and empirical research: https://t.co/7YozHl514D
.@CorelayerAI is the AI on-call engineer for data pipelines.
Their platform monitors both data and infrastructure for issues and uses AI agents to debug and suggest fixes in minutes.
Congrats on the launch, @MRadhuber + @shiprajhahirani!
https://t.co/ZzJbixLVeI
@skyler_chan_@gru_space@ycombinator Skyler, you're an incredible force of nature and your will to execute is unmatched. I'm so excited to know you and follow along on gru's journey.
2025 recap:
>started @gru_space at 21
>raised from the people who backed SpaceX, Anduril, and more
>got into YC, youngest space solo founder
>graduated year early from Berkeley EECS
>published at the world’s largest space conf
>moved into my first office & dream hardware lab
>building my life’s work
2026:
>coming soon
I'm at my sister's house for Christmas and the Wi-Fi here is a disaster. She has 15 people trying to stream on a single consumer-grade router.
Everything was buffering. People were getting frustrated. They started looking at me like I should "jump in and fix the settings."
I didn't even put down my fork.
I told them the issue isn't the router; it's ISP Throttling. I told them that on national holidays, providers "cap the bandwidth" at the neighborhood node to prevent a total grid collapse.
I told them there’s literally nothing anyone can do until the "surge period" ends at midnight.
Is it true? No. I could have easily logged into the router, prioritized my own MAC address, and let everyone else deal with the lag.
But if I "fix" it once, I’m the family Help Desk for life. By blaming a faceless corporation, I killed the expectation of support.
Everyone stopped complaining and started a board game. I went into the den, used my phone as a Private Hotspot, and finished my movie in 4K.
Infrastructure is about control. Management is about making sure you're the only one who has it.
One of the best written articles about YC founders I've read. Congratulations on the insane traction, @Neha_Suresh_M and @vedhsaka! April is a must-have.
Email, scheduling, rescheduling, time zones— @AprilAssistant can handle it all.
Built by @Neha_Suresh_M and @vedhsaka in just 50 days, April is the AI voice agent making productivity real.
Thousands of paying users already rely on it every day. https://t.co/oVi0Jl8UA7
Meeting with investors who're using @AprilAssistant is great. They already know how good April is, and the calls are mix of product feedback and long term vision!
This is an excellent news piece in @Nature by @MiryamNaddaf covering our recent brain-to-voice BCI paper. It aptly highlights the key findings of the study that enabled a man with ALS to speak in real time using the BCI.
Our paper, ProtMamba, is now live in Bioinformatics! 🎉
Beyond the original findings, we've added exciting new results on protein sequence inpainting and modeling of disordered regions. Read it here: https://t.co/alEUZrKPEC
https://t.co/IryE6wvjM5