Alex

[Alex @wale_lol]

@TimePieChina @LammingLab meanwhile protein chips and ramen are the new hottest thing

[Alex @wale_lol]

@BioavailableNd googled "average income in pomeranian voivodeship" vs "average income in lublin voivodeship", higher income has lower T1D rate

[Alex @wale_lol]

@nicknorwitz you know your right leaning audience that eats up your LDL skepticism is gonna hate this post, right

[Alex @wale_lol]

@MrBeast 70% of you would really prefer money over a guaranteed 100 year lifespan? You know most of you are not making it to 100, right?

[Alex @wale_lol]

@caloriesproper2 I'm happy assuming it is anti-catabolic but not anabolic until proven otherwise (prob didn't change in this study). Mainly helpful when cutting

[Alex @wale_lol]

@hsu_steve So you think the entropic limit is fundamentally sound with no foreseeable solution?

[Alex @wale_lol]

@mike_lustgarten Would you ever consider thymic regeneration self-experimentation?

[Alex @wale_lol]

@siimland Not that there is any reliable way to answer this, but what do you think is the lifespan increase if someone took all of these daily since, say, age 45? Given that exercise adds about 10 years between top-bottom quartiles, effect size probably smaller (but how much?)

[Alex @wale_lol]

@caloriesproper2 Been a while since I looked at the studies, but my conclusion was that TRE shows no benefit from skipping breakfast but skipping dinner sometimes does. Most plausible conclusion is small but extant effect size from having the last meal as far from bedtime as possible.

[Alex @wale_lol]

@siimland Adds like 8 years to your life at most. That is a lot or a little depending on how you look at it (and how much you hate exercise)

[Alex @wale_lol]

@MrBeast 5,555,556

[Alex @wale_lol]

@TakeThiamine @anabology I don't think anyone buys that he's doing this out of altruism and not ego and profit. Like capitalism though, others can benefit from selfishness

[anabology @anabology]

If all the "steak and sunshine" bros measured their body as much as Bryan, they'd find 10x the complications that he's finding

Bryan the man in the arena

[Alex @wale_lol]

@siimland Why testimonials are close to useless

[Alex @wale_lol]

@caloriesproper2 @johnlocke2076 Just learned about how fat can't make glucose (besides the glycerol backbone) in physiology; does this suggest muscle loss is literally biochemically inevitable with fasting? Baseline glucose needs, even during ketosis, will have to come from a non-adipose source

[Alex @wale_lol]

@BenMazer @thisisalimirza I think I'm beginning to appreciate that overdiagnosis isn't a simple problem to fix; mass screening won't improve outcomes in the short term. But perhaps it does in the long-term? The idea that more data won't EVENTUALLY be helpful seems implausible to me.

[Alex @wale_lol]

@thisisalimirza @BenMazer Wish you didn't put 2 questions in one post. They just answered the second one because it's easier

[Alex @wale_lol]

@ZKForTre @foundmyfitness The studies youve posted among others seem to paint the picture that early TRE does in fact offer a unique benefit above caloric restriction. It just isn't that big?

[Alex @wale_lol]

@SPXSatoshi tons of replies, doesn't sound like anyone really knows. Probably a complicated+nuanced explanation that defies the simple narrative people love

[Alex @wale_lol]

@DrDominicNg Are those other things really bad proxies though? Could be "good enough" for most people, sort of like LDL-C