New #JITC article: Concurrent immune checkpoint inhibition and selective immunosuppressive therapy in patients with immune-related enterocolitis https://t.co/z7w7E6Zo2u @YRBadran
Thrilled to share our study of concurrent biologic tx during ICI rechallenge after colitis.
👉 ⬇️ Recurrent severe colitis (20.8% vs 34.4%)
👉 No difference in safety outcomes or survival
https://t.co/AM5ZvbhCS6
@MSKCancerCenter@MPostow@YRBadran@MGHMedicine@MDAndersonNews
We report here the safety of using infliximab or vedolizumab concurrently with immune checkpoint therapy in patients with prior immune-checkpoint colitis ⭐️Recurrent severe colitis (20.8% (IFX or Vedo) vs 34.4% (control) https://t.co/wCppUg3dqo
Incredible to see how different the dominant negative RELA phenotype is from our first report of RELA haploinsufficiency back in 2017
https://t.co/ybgsGq5Yui
beautiful work @SatoshiOkada3@casanova_lab
Somatic mosaicism is emerging as a new frontier in genomics.
@NIH has invested $140M to deeply characterize genomes across and within individuals.
Really excited to co-lead @broadinstitute's effort with @KArdlie@nialljlennon!
https://t.co/7krslPa2W1 #SMaHTConsortium
1/ Together with the COVID Human Genetics Effort, we are happy to report our finding of inborn errors of the OAS-RNase L pathway in children with MIS-C #Misc#Pims in @ScienceMagazine (https://t.co/91A7lEY3HM)
It was an honor working with @drkylestaller and @KlempnerSam on this @NEJM@NEJMCPC highlighting important concepts in GI motility and gastric cancer. Promised good read! https://t.co/Rg7ayPw8yg
Zain Virk describes two reports of persistent Heyde syndrome despite SAVR/TAVR. Subsequent bevacizumab controlled their bleeding! More data needed on antiangiogenic therapy for refractory angiodysplastic bleeding. https://t.co/KftkpKqBOL #hematology@HannyAlSamkari@YRBadran 2/2
Very excited to share I’ll be heading home to Oklahoma to join @OUHealth as Associate VP of Clinical Innovation and practice as an internist. Look forward to working with system leaders to continue to improve health care in the state. @OUskullbaseMD@HakeemShakirMD@DaleBratzler