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[Memorial Sloan Kettering Cancer Center @MSKCancerCenter]

Donna was diagnosed with pancreatic cancer at age 66 when she and her husband were visiting one of their daughters in Australia. When they returned to the U.S., they immediately came to MSK for care, where she learned she was eligible for an investigational vaccine trial, to prevent pancreatic cancer from returning after surgery.

MSK hepatopancreatobiliary surgeon Dr. @Jeffrey_Drebin, physician-scientist @TheVinodLab, and medical oncologist @EileenMOReilly walked Donna through each step.

“They described how they would take part of my tumor to make a personalized vaccine, and it sounded amazing,” Donna says. “My husband and I had a moment of concern about delaying chemotherapy, but all the doctors made me feel so comfortable that we took the leap of faith and said, ‘Go for it.’”

Over the next few months, Donna received an immunotherapy drug and eight doses of the vaccine, followed by chemotherapy, and then a final vaccine dose.

Today, Donna is 72 and recently celebrated her 50th anniversary with her husband in Sicily and spends as much time as she can with her daughters and six grandchildren.

Learn more about this clinical trial, presented at the 2026 American Association for Cancer Research Annual Meeting: https://t.co/C0IwK11OaA

#AACR26

[Eric Topol @EricTopol]

It worked. Stem cells (mesenchymal) given to patients with a large heart attack reduced major adverse events in a randomized trial vs standard care https://t.co/ycKZKshxiX

[Samuel Hume @DrSamuelBHume]

Recent Covid vaccination is associated with better response to immune checkpoint blockade, and therefore better survival, in lung cancer and melanoma

(This are observational data in humans, and were replicated in controlled experiments in mice)

If untargeted vaccines can do this, imagine what targeted cancer vaccines could do...

[Eric Topol @EricTopol]

Many people ask me "Should I get a Galleri blood test for early cancer detection?"
Here are the latest data
https://t.co/SuSTyk23Tr

[Cancer Cell @Cancer_Cell]

Online Now: Tumor-infiltrating bacteria disrupt cancer epithelial cell interactions and induce cell-cycle arrest https://t.co/moHP3UCY4n

[Nature Metabolism @NatMetabolism]

Tumour-associated macrophages serve as an acetate reservoir to drive hepatocellular carcinoma metastasis https://t.co/kQZM2G2MTS

[Eric Topol @EricTopol]

Cancer stem cells (CSC) are elusive and one of the reasons for resistance to treatment. Machine learning led to discovery of a way to promote their self-destruction (apoptosis)
https://t.co/LzMIvibtSJ

[Nature Biotechnology @NatureBiotech]

Programmable promoter editing for precise control of transgene expression https://t.co/6jC9QnVgzn

[David Sinclair @davidasinclair]

Fertilized human eggs made from skin cells progress through normal cell divisions, ultimately developing into embryos https://t.co/8rLonbH7M9

[National Geographic @NatGeo]

Primatologist, conservationist, animal advocate, educator, and National Geographic Explorer Jane Goodall has died at age 91. Goodall’s decades of research into the lives of wild chimpanzees transformed our understanding of these intelligent apes. https://t.co/i3qzfDIAzg

[Science Magazine @ScienceMagazine]

Two of the world’s deadliest mosquito vectors—Aedes aegypti and Anopheles funestus—have evolved, spread, and adapted in ways that complicate global disease control, two studies show in Science.

📄: https://t.co/OdCw3Wb5fm
📄: https://t.co/O8tnmeenI1

[Prof. Nikolai Slavov @slavov_n]

bioRxiv has a dedicated section for negative results.

Use it.

Share negative results.
Your colleagues will appreciate it.

[Nicholas Fabiano, MD @NTFabiano]

Huntington's disease was successfully treated for the first time with gene therapy.

75% reduction in symptoms & 113% protection of cognition.

This is what a real medical breakthrough looks like.

[Satvik Pendyala | 彭尚威 | సాత్విక్ | सात्विक @Satvik_Pen]

If you really want India to attract talent back to India, you need to implement decentralized, local, in every ministry, talent application programs. Without that you don't get scale nor absorption
Here's a non comprehensive list of China's programs:

[Samuel Hume @DrSamuelBHume]

5 breakthroughs in medicine this week

1. Highly effective obesity pills are nearly here

Eli Lilly’s oral Orforglipron and Novo Nordisk’s oral semaglutide both achieved ~10% weight loss in phase 3 trials

Here’s how they compare to the rest of the pipeline:

[Neil Stone @DrNeilStone]

It's not right vs left

Its the extremes vs everyone in the middle

[Molecular Cell @MolecularCell]

Online Now: Structural insights into DdCBE in action enable high-precision mitochondrial DNA editing https://t.co/ip6RX7BnoU

[Yuan Yi Zhu @yuanyi_z]

I don't think anyone who's salivating at the prospect of mass political violence or civil war has the foggiest idea of how bad these things are in real life. It's beyond their memory and their imagination.

[Dr Gill @ikpsgill1]

The Punjab floods showed that solidarity knows no boundaries. From govt agencies to neighbouring states like Haryana, Himachal, Delhi, UP, Rajasthan & even from South, from gurdwaras & NGOs to farmers & youth, from NRIs to celebrities - every hand that rose in sewa became a lifeline.
Thank you each and everyone 🙏🏼

#PunjabFloodRelief

[Prof. Nikolai Slavov @slavov_n]

These findings add to the increasing evidence that cancer is not driven solely by DNA mutations.

🧵