Thrilled to share that my final PhD work has been published in @NatureComms! Grateful to the reviewers for their valuable feedback that significantly enhanced the manuscript. Check out the final version here: https://t.co/KcLdvhBU7t
Happy to share my PhD’s final preprint! We’ve unveiled DENND6A's role as an Arl8b effector that links lysosomes to RILP-dynein via Rab34 activation, thus regulating lysosomal retrograde transport & autophagy. 🙏to my supervisor @petermc29528605#lysosome#retrograde#autophagy
Thrilled to preprint my postdoc work in the @IoannouLab ! 🚀 Using live-cell and two-photon imaging, we reveal that Parkinson’s-linked glucosylceramide changes drive the formation and shedding of ectosomes, fueling α-synuclein spread. This pathway has broad implication in PD.
Image shows how Rab11 interacts with MICAL1 to promote F-actin depolymerization. From Zhai, Li, Wang et al. showing that TBC1D20 coordinates vesicle transport and #actin remodeling to regulate ciliogenesis. https://t.co/dSDNUjuTaO
#Cytoskeleton#Disease#Cilia
It was an absolute dream to help with this Method of the Year! SPATIAL PROTEOMICS gets a well-deserved spotlight! Thanks so much to all the authors who contributed their comments! @RongFan8@BodenmillerLab@leeat_keren@labs_mann @DanielaQuail
Thrilled to present Patho-DBiT out @CellCellPress A first-of-its-kind technology for spatial whole transcriptome sequencing of clinically archived FFPE tissues, mapping various large/small RNAs, alternative splicing, and genome-wide SNV, all at once from the same tissue section!
Our new paper, in collaboration with the @KarolinaSkvaro1 group @UniKarlova @FnMotol, reveals that patients with the c.269 T>C variant in AP1S1 manifest all symptoms of MEDNIK syndrome, not just enteropathy. 📄 Read it here: https://t.co/ad1XySe1W8.
For 25 years, the Toll-like Receptor pathway was considered a series of distinct protein complexes that drive inflammation. Today, we report that the entire pathway, from receptor to transcription factor, is executed from within one complex—the myddosome.
https://t.co/J9xnnt0xXD
#Lysosomes are crucial cellular degradation centers, but how can one selectively modulate their activity? This study describes novel #optogenetic tools for the light-inducible manipulation of lysosomal physiology in cells & in #Celegans#PLOSBiology https://t.co/nZ8TAnSLYb