Excited to share our latest study, published in @NatureComms, on X-linked lncRNA loci and their epigenetic signatures! Here we dissected the in vivo roles of Crossfirre, Firre, and Dxz4, exploring their potential impacts on imprinted & random XCI, as well as on autosomes 👇
We recruit Junior Group Leaders at the new Helmholtz-Institute for Translational AngioCardioscience (HI-TAC): 5+4 years. Work in the Heidelberg-Mannheim area in collaboration with the MDC Berlin! Apply now or latest Jan 6! https://t.co/tOJQP7yzlY
Brief Report: Neurodevelopmental Disorder Caused by Deletion of 𝘊𝘏𝘈𝘚𝘌𝘙𝘙, a lncRNA Gene https://t.co/CGJBEJsLWz
Science behind the Study: Linking a Neurodevelopmental Disorder with a lncRNA Deletion https://t.co/wX5AUyrYq5
#Genetics
Could Mex3a be the key to preventing atherosclerosis? New findings reveal its role in endothelial integrity and inflammation—could this RNA-binding protein be a new therapeutic target for CAD? @5antus@FlorianaFarina@ChenZhifen https://t.co/gMuKZFRlel
Today, we report a critical role for the ubiquitin-proteasome ⛓️🧵system in ferroptosis☠️- DDI2-mediated activation of NFE2L1 protects from cell death - important implications for proteostasis, cancer, and neurodegeneration - explore the ubiquitome!
👇
https://t.co/YkE5UdTbnN
The Nobel Prize in Physiology or Medicine goes to #RNA biologists again this year!
In this case, I am glad that we added a small piece to the remarkable let-7 biology, highlighted in the cover story a few years ago:
https://t.co/TzVFpy1kkW
To my Munich based tweeps:
Please join us for this FREE @FASEBorg Mini-Symposium on CVD and Cancer featuring @BernhagenLab @kistanford6@5antus @Y_Asare_ et al. plus special insight sessions on how the FASEB Journals work!
BREAKING NEWS
The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.
MicroRNA genes have evolved and expanded within the genomes of multicellular organisms for over 500 million years.
Today, we know that there are more than a thousand genes for different microRNAs in humans, and that gene regulation by microRNA – discovered by this year’s medicine laureates – is universal among multicellular organisms.
#NobelPrize
Passenger mutations in KO mice can alter nearby gene expression & affect experimental outcomes!
Inherited mutations, from donor strains, may lead to misleading phenotypes.
Always consider them in your study design!
Here is an example we just published:
https://t.co/8xJ11NkWGh
1/8 Grateful and happy that our new story on the mechanism of #stroke recurrence in the context of large-artery #atherosclerosis is out in @nature.
Big Thanks to our lab @ArthurLiesz @JiayuCao @ISD_Research and all esteemed authors to make it happen!
DOI: https://t.co/JNGTnURWE7
Finally out today! Very proud of this story:
Innate immune memory after Stroke drives remote organ pathology
This study was led by superstar-postdoc @SimatsAlba and X-less Sijia Zhang. @CellCellPress
https://t.co/0pvrxibv6P