Donato Santovito

MD | PhD | Autophagy, non-coding RNAs & epigenetics in cardiovascular medicine | @ipekresearch @dzhk_germany

[Donato Santovito @5antus]

Wow! Congrats @Y_Asare_ and friends for this amazing work! 😊

[Formula 1 @F1]

End of an era.

#F1 #AbuDhabiGP

[Scuderia Ferrari HP @ScuderiaFerrari]

Poles, wins and nothing short of iconic moments. Gracias, Carlos ❤️

[Donato Santovito @5antus]

Congratulations @DAndergassen, @HasenbeinT, @sarahhoelzl, very well deserved!! #science #lncRNA

[Daniel Andergassen @DAndergassen]

Excited to share our latest study, published in @NatureComms, on X-linked lncRNA loci and their epigenetic signatures! Here we dissected the in vivo roles of Crossfirre, Firre, and Dxz4, exploring their potential impacts on imprinted & random XCI, as well as on autosomes 👇

[Sabine_Steffens @SteffensLab]

Recruiting the next generation of medical students @ipekresearch @CRC1123_Athero today at the DoktaMed @LMU_Uniklinikum with @_LauraParma @5antus

[Johannes Backs @JohannesBacks]

We recruit Junior Group Leaders at the new Helmholtz-Institute for Translational AngioCardioscience (HI-TAC): 5+4 years. Work in the Heidelberg-Mannheim area in collaboration with the MDC Berlin! Apply now or latest Jan 6! https://t.co/tOJQP7yzlY

[NEJM @NEJM]

Brief Report: Neurodevelopmental Disorder Caused by Deletion of 𝘊𝘏𝘈𝘚𝘌𝘙𝘙, a lncRNA Gene https://t.co/CGJBEJsLWz

Science behind the Study: Linking a Neurodevelopmental Disorder with a lncRNA Deletion https://t.co/wX5AUyrYq5

#Genetics

[Donato Santovito @5antus]

Special thanks to @JamesHendo2021 @vastriantafyl @ChenZhifen @FlorianaFarina @RemcoMegens @YvonneDoring @Sattler_lab and all other (twitterless) friends and collaborators.

[Donato Santovito @5antus]

🔬New research from @ipekresearch

Here, we provide insights on the protective role of the RNA-binding protein MEX3A in human and mouse atherosclerosis.

@CRC1123_Athero @trr267 @CircAHA @dzhk_germany @YoungDZHK

[Circulation @CircAHA]

Could Mex3a be the key to preventing atherosclerosis? New findings reveal its role in endothelial integrity and inflammation—could this RNA-binding protein be a new therapeutic target for CAD? @5antus @FlorianaFarina @ChenZhifen https://t.co/gMuKZFRlel

[Alexander Bartelt @BarteltLab]

Today, we report a critical role for the ubiquitin-proteasome ⛓️🧵system in ferroptosis☠️- DDI2-mediated activation of NFE2L1 protects from cell death - important implications for proteostasis, cancer, and neurodegeneration - explore the ubiquitome!
👇
https://t.co/YkE5UdTbnN

[Chaolin Zhang @chaolinzhang]

The Nobel Prize in Physiology or Medicine goes to #RNA biologists again this year!

In this case, I am glad that we added a small piece to the remarkable let-7 biology, highlighted in the cover story a few years ago:
https://t.co/TzVFpy1kkW

[Alexander Bartelt @BarteltLab]

To my Munich based tweeps:
Please join us for this FREE @FASEBorg Mini-Symposium on CVD and Cancer featuring @BernhagenLab @kistanford6 @5antus @Y_Asare_ et al. plus special insight sessions on how the FASEB Journals work!

[Donato Santovito @5antus]

@JMaliheh Indeed! 😉

[Donato Santovito @5antus]

😊😊😊

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.

[The Nobel Prize @NobelPrize]

MicroRNA genes have evolved and expanded within the genomes of multicellular organisms for over 500 million years.

Today, we know that there are more than a thousand genes for different microRNAs in humans, and that gene regulation by microRNA – discovered by this year’s medicine laureates – is universal among multicellular organisms.

#NobelPrize

[ᒍOᕼᗩᑎ ᗪᑌᑕᕼEᑎE @DucheneJohan]

Passenger mutations in KO mice can alter nearby gene expression & affect experimental outcomes!

Inherited mutations, from donor strains, may lead to misleading phenotypes.

Always consider them in your study design!

Here is an example we just published:
https://t.co/8xJ11NkWGh

[Charles Leclerc @Charles_Leclerc]

Siete i numeri 1 ❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️
Forza Ferrari ❤️

[Stefan Roth @StefanRoth86]

1/8 Grateful and happy that our new story on the mechanism of #stroke recurrence in the context of large-artery #atherosclerosis is out in @nature.
Big Thanks to our lab @ArthurLiesz @JiayuCao @ISD_Research and all esteemed authors to make it happen!
DOI: https://t.co/JNGTnURWE7

[Michele Pelacci @Pelamity]

Abruzzo regione più sottovalutata d’Italia: confermato e ormai ufficiale

[Arthur Liesz @ArthurLiesz]

Finally out today! Very proud of this story:

Innate immune memory after Stroke drives remote organ pathology

This study was led by superstar-postdoc @SimatsAlba and X-less Sijia Zhang. @CellCellPress

https://t.co/0pvrxibv6P