Natsuki SHINODA

A Caspase Lover working as a Senior Researcher at AIST

[Natsuki SHINODA @ACaspaseLover]

We've posted a preprint: "Early-peaking caspase-7 activity at the plasma membrane drives apoptotic phosphatidylserine exposure” — the culmination of my 12-year journey and love for caspase, with incredible efforts by Yusuke Taira in Masayuki Miura lab.
https://t.co/QKLmh4TifZ

[nature @Nature]

Nature research paper: Lsp2 links early-life diet to adult translation and lifespan in Drosophila

https://t.co/tWjQNm3Lxw

[Hina Kosakamoto @Hina_kosakamoto]

Excited to share that our work from RIKEN is now published in Nature! 🎉
We uncovered how protein intake during development shapes lifespan and identified a mechanism that transmits a “nutritional memory” into adulthood.
https://t.co/Kz8VVxsCv9

[FumiAki Obata @Fumiaki1984]

@RIKEN_IMSの今見さんとの共同新作が@Natureに出ました。発生、成長期の一過的な栄養制限で寿命が延びる分子メカニズムをハエで解きました。成長過程で摂取したアミノ酸をトレースする技術、遺伝学、栄養操作、代謝分析により、栄養状態が記憶される分子機構を同定しました。https://t.co/0jmDl9DyNB

[Naoki Okamoto @NaokiOkamoto23]

Today, I’m starting my own lab as a professor at Nagoya University!
By a wonderful coincidence, my lab is located in the very same place where my graduate lab once stood.
I’m excited to devote myself to research and education, and to advancing the field of insect endocrinology!

[Cell Structure and Function @CSF_JSCB]

来年のポスター。可愛い！

[バイオステーション(Bio-station)/ポッドキャスト @Bio_stations]

大規模解析による脂質結合プローブの開発と改良

Yeastディスプレイ法とNGSを組み合わせ、数千ものタンパク質と脂質との相互作用を解析する新手法を確立。特定の脂質に対して高い親和性を持つ新型バイオセンサーを創出。オートファジー解析などに有用

すごいです！
https://t.co/lnIHwkS6UV

[Mizushima Lab (UTokyo) @MizLabUT]

Our new paper is out in @ScienceMagazine! We developed mice with reversible control of autophagy, and showed that restoring this pathway after its suppression reverses neuronal abnormalities and brain dysfunction, demonstrating the resilience of neurons. https://t.co/kegmU08mcY

[Yasushi Tamura @Tamura_Lab]

やっと出ました。このご時世に著者2名の論文です。大学院生の藤本君が頑張りました。超力作なのでぜひご覧ください。
https://t.co/5TB4YvimGH

[nature @Nature]

Happy 30th birthday, Pokémon! Since 1996, the Japanese media sensation has inspired generations of researchers in fields as diverse as evolution, biodiversity and research integrity. https://t.co/xDkf4D7VyT

[JSDB @_JSDB_]

日曜夜のNHKサイエンスZEROで細胞競合を紹介してもらいます。井垣さんがスタジオ登場で、石谷研究室の筋肉の細胞競合、佐々木洋研究室の胚の細胞競合なども紹介してもらう予定です。
https://t.co/JquFRvr7Ym

[Natsuki SHINODA @ACaspaseLover]

Building on our previous finding that Drosophila caspase Dcp-1 promotes tissue growth in a non-lethal manner, we identify regulatory factors, including the giant IAP Bruce, that shape this non-lethal activity using TurboID and AlphaFold3 in collaboration with @YHama0105.

[Natsuki SHINODA @ACaspaseLover]

I am happy to announce that our “Reviewed Preprint” has been published in
@elife: Bruce suppresses autophagy-regulated caspase activity and wing tissue growth in Drosophila
https://t.co/oDv6e17eNW

[Alice Ting @aliceyting]

New work describes our efforts to achieve CRISPR editing of the mitochondrial genome.

https://t.co/8Jc51WnEmg

The CRISPR toolbox has revolutionized the study of nuclear DNA, but the mitochondrial genome (mtDNA) has remained out of reach, mainly because there are no known ways to deliver sgRNAs across both outer and inner mitochondrial membranes.

Yet many organisms have evolved mechanisms to transport RNAs across their mitochondrial membranes. Trypanosomes, for example, do not encode any tRNAs in their mtDNA, and must import all of them from the cytosol to support intra-mitochondrial protein translation.

We started with yeast. We engineered a strain that must repair a STOP codon in mtDNA (an arginine biosynthesis gene) to survive. After screening a library of sgRNA import sequences, we identified one that enables a small degree of functional CRISPR editing in mitochondria.

Graduate student Sifei Yin obtained these exciting results several years ago, and spent the intervening time understanding how sgRNA import works, and how to make it better. Read the paper to learn what she uncovered!

[Cell @CellCellPress]

Now online! Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity https://t.co/5DfpvK4qA7

[Najafov Lab @AyazNajafov]

We are happy to announce that the first paper from the Najafov Lab has been published in @Nature! In this study, we identified SIGLEC12 as a mediator of plasma membrane rupture (PMR) for necroptotic cell death using a genome-wide CRISPR-based systematic approach. @UTSWMedCenter @UTSWScience @UTSWNews @UTSWInternalMed @CRI_UTSW #necroptosis #MLKL
https://t.co/nB2yHIRUEi

[日本の研究.comニュース @rjp_news]

【注目プレスリリース】炎症の鍵となるIL-1βの放出メカニズムを単一細胞レベルで「見る」ことで解明 ―炎症性サイトカインIL-1βは細胞死に伴って放出されていた― / 東京大学,京都大学,東京科学大学 https://t.co/TmjGU8qBTt

[産業技術総合研究所（産総研） @AIST_JP]

見逃したみんな、待たせたな─────

ヨビノリたくみ@Yobinori × 産総研 の講演会、
ついに、 YouTubeで大公開🎉

会場の熱気そのままに
研究生活のリアルに迫る60分を、フルでお届け🔥

見逃すと、ガチで後悔します。👇
https://t.co/bR6tTiQTwL
#産総研特別公開2025

[Naoki Okamoto @NaokiOkamoto23]

Our new paper is out in Nature! We discovered that the neuroendocrine peptide Capa acts as a calcium-mobilizing hormone in the fruit flies, showing that even boneless insects have a vertebrate PTH-like endocrine system for calcium homeostasis.
https://t.co/d2la76xu89

[産業技術総合研究所（産総研） @AIST_JP]

#産総研特別公開2025 ご来場、ありがとうございました🎉
ヨビノリたくみさん（@Yobinori）× 産総研の研究者3人による講演会、「語り合おうぜ、[研究] 愛。」は、満員御礼＆大盛況🔥

「見に行きたかった…！」という声にお応えして…
🎥アーカイブ動画、ただいま準備中──！
続報をおたのしみに🍀

[JST CREST・さきがけ・ACT-X @JST_Kisokenkyu]

2025年度の採択結果を公開しました。
各領域の
✓今年度の採択課題
✓選考についての総括総評
などを公開しています。

◎プレスリリースはこちらです。
https://t.co/ifI8BCt4nS

◎CREST
https://t.co/8m47BwDKUY

◎さきがけ
https://t.co/0ro6X1GH6z

◎ACT-X
https://t.co/XjsCVDxslN