Alexander Aichinger

Waiting for Longevity Escape Velocity. Scientists and Technology is the Way. Until then: sleep, fast, diet, supplements, exercise. From Austria. ALS advocate.

[Alexander Aichinger @AlexanderAichi6]

@mario_lochner Irgendeine Korrektur wird schon kommen aber ist es der Big Bang wie .com oder der schleichende Niedergang.

[Alexander Aichinger @AlexanderAichi6]

@ericxing This is huge

[Eric Xing @ericxing]

We are proud to release the world's first virtual cell -- a multi-modal, multi-scale, dynamic, and stateful world model of the cell, the first step toward an AI-driven Digital Organism (AIDO).

[Alexander Aichinger @AlexanderAichi6]

@mario_lochner Ganz so ist es ja nicht. Linke und Rechte Themen lassen sich sehr einfach transportieren. Die Themen der Mitte sind nicht so greifbar. Der Kompromiss oft nicht verständlich. Mit der Masse der Leute wird das nicht funktionieren.

[Alexander Aichinger @AlexanderAichi6]

@GiaMMacool Yeah they say that but they are not dumb… they mean they dont love you any more. So stay HoT and be ready.

[Alexander Aichinger @AlexanderAichi6]

@eyojoel77 Its not about the others its about you. I had several girlfriends an always the Same experience until I know now its about me… only about me. I do what I want when I want who is with me? Lets go some Part together learn something and move on.

[Alexander Aichinger @AlexanderAichi6]

@guideforlovers I had the Same Problem and plenty of others Girls who want to sleep with me. Its not you who has the Problem it is nature. Your marriage is done anyway. So lets Open it and See what you can get. Just Tell her that it is no Option to Go on Like That.

[Alexander Aichinger @AlexanderAichi6]

@DearS_o_n Dont do what anyone expects. Woman will do whatever they want. The leave nice guys and scumbags to … so it doesnt matter. Do what ever you like an See who is with you.

[Josh Chambers @JoshChambers]

Michael Jordan says losing is not the opposite of winning, it is just another part of winning

“I hate losing. It’s not even a question. But I have to respect losing…”

“Because losing is a part of winning. You never just win. You’ve got to lose to win.”

“Losing is going to hurt… To a point where you look at… How can I do things different? How can I change? How can I make this team better?”

“Before you can look at someone else… You’ve got to look at yourself in the mirror. That’s how things get started. You’ve got to be willing to change.”

[Donald J. Trump @realDonaldTrump]

We’re going to bring this heroic young man, and his family, into the White House with, perhaps, the boy he saved, to give him a High Civilian Honor. Very brave, he deserves it! President DONALD J. TRUMP

[Alexander Aichinger @AlexanderAichi6]

@GiaMMacool https://t.co/yBDNfLhNgT

[Alexander Aichinger @AlexanderAichi6]

@bryan_johnson I love your Motivation. Combine that with Money and you have the Perfect Problem Solving Machine 💪 good luck

[Alexander Aichinger @AlexanderAichi6]

@jpsenescence I think @turn_bio is working on it.

[Revel Pharmaceuticals @revelpharma]

Hello world 👋 We're building the first medicines to repair the aging extracellular matrix, the scaffold that holds your body together.

Our new results in Nature Communications got picked up by @theallinpod, @bryan_johnson, @davidasinclair, @afshineemrani, and many others.

What did we find? Let's dig in 🧵

Cells get almost all the attention in biology. But cells don't live in a vacuum; they're held up by structural tissue, the extracellular matrix. Collagen, elastin, and the scaffolding that gives your body its shape.

As the matrix accumulates chemical damage over time, its properties change. Skin sags, arteries stiffen, and the damaged matrix draws in immune responses and drives oxidative stress.

It's one of the root causes of aging, and it's been largely neglected.

Natively, our bodies can't repair this damage. But some bacteria have enzymes that can break these chemical bonds. So we asked: can we engineer highly efficient, therapeutic versions of these enzymes? Many said it couldn't be done. We built a platform to do exactly that.

CML forms via the same Maillard reaction that browns bread: slowly, over a lifetime, at body temperature. Protein-bound CML has been considered irreversible for 40 years. You can't untoast bread. 🍞

So we built CMLase, an enzyme that clips CML off proteins and restores the original. We screened tens of thousands of natural enzymes, then ran directed evolution across 500 million variants of the best ones. In vitro, it works.

More importantly: CMLase reverses CML in real ex-vivo human tissue from elderly donors. This is the test that matters. So many aging interventions look great in mice and fail in humans.

After applying CMLase overnight to tissue from elderly donors, residual CML dropped to levels seen in far younger tissue. In elderly skin: a 55%+ reduction, down to below the level of 31-year-old skin.

This is just the start. We've shown proof-of-concept that engineering enzymes to rejuvenate the extracellular matrix is possible: untoasting the proverbial bread. We're raising our Series A soon. If you believe, like @chamath at the @theallinpod, that this is a trillion-dollar market, get in touch.

[Alexander Aichinger @AlexanderAichi6]

@revelpharma @theallinpod @bryan_johnson @davidasinclair @afshineemrani I love science 🥰

[David Alaba @David_Alaba]

Never give up. GEMMA!!! ❤️🇦🇹

[Fórmula Directa @FormulaDirecta]

💡 Carlos Sainz: "Tengo una idea para la F1: correr dos carreras con cada uno de los coches de la parrilla durante la temporada"

👉 "Entonces el piloto es parte de la F1, no es parte de un equipo, es un cliente que la Fórmula 1 contrata para llevar los coches".

👉 "Entonces yo tendría mi oportunidad de hacer dos carreras con Williams, dos con Mercedes, dos con Ferrari... Todos los pilotos tendríamos exactamente la misma oportunidad de ganar el Mundial".

👉 "Conseguirías desasociar por completo las marcas de los pilotos. y así tendrías un campeonato real de pilotos y un campeonato real de marcas".

[@mundodeportivo]

#F1

[First Doctor @FirstDoctor]

BREAKING: Scientists have engineered a virus that invades and destroys glioblastoma one of the deadliest brain cancers. It also turns the immune system into a relentless tumor-killing force. This could be such a super historic shift in cancer treatment.

[Alexander Aichinger @AlexanderAichi6]

@davidasinclair @danielsil44 I would love to see if we can Repair some damage in a Safe way. Step by Step 💪