Alice B. Popejoy, PhD

Public Health Genetics PhD; Stat/Pop Gen.
Computational evolutionary genomics and diversity.
Ethical, legal, and social implications (ELSI).
Black Lives Matter.

[Alice B. Popejoy, PhD @AlicePopejoy]

Thanks so much @GenomicsNZ and @CartneyAnn for hosting me (and @NanibaaGarrison) yesterday.
It was an honor to present our work on the embedded ELSI team of the US @HumanPangenome project.

Our key question for you (and now Twitter): What makes a research partner TRUSTWORTHY?

[GenomicsAotearoa @GenomicsNZ]

REMINDER: Today's Genomics Aotearoa Seminar is at 10am, as we have international speakers Dr Alice Popejoy and Dr Nanibaa’ Garrison talking about the Human Pangenome Reference Consortium🌏🧬

See you in a few minutes!

[Dr. Krystal Tsosie, PhD, MPH @kstsosie]

Yá'át'ééh! The Tsosie Lab for Indigenous Genomic Data Equity and Justice @ASU is looking for #Indigenous PhD mentees in the areas of genetics, human health, data science, ethics. Degree programs across @asuSOLS and @ASUSST. Deadline Dec 1st. DM or email: https://t.co/fWAowj1jod

[The American Journal of Bioethics @bioethics_net]

Our July ELSIcon Special Issue is out! Read it here: https://t.co/wfXHxEwx03

#MedEd #ELSI #genetics

[ELSIhub | CERA @ELSIhub]

"Humanity’s genetic variability cannot be captured simply by sequencing the genomes of more people."

CERA co-directors @mildredkcho and @sandrasoojinlee call for the HPRC to invest in interdisciplinary teams committed to equitable collaboration. https://t.co/nplVFBnAj3

[Alice B. Popejoy, PhD @AlicePopejoy]

@DocEdge85 Osaka-ya in Sacramento has unbelievably good shaved ice. We also have Gunther’s fruit freeze, which is like shaved ice made with frozen fresh fruit w/out the added syrup. Worth a trip?

[Front Line Genomics @FLGenomics]

@AlicePopejoy (Assistant Professor, @ucdavis and member of @HumanPangenome) will be sharing the importance of building a #pangenome to gain a better understanding of global genomic diversity at #FoGBoston. Find out more about the Festival’s agenda here: https://t.co/VJ6p4RGpzR

[ELSIhub | CERA @ELSIhub]

The lack of diversity in human genomics research and reference datasets is a problem, with real-life consequences, but the path forward remains elusive. Explore our latest ELSIhub Collection: How Do We Diversify Human Genomics Research? from @AlicePopejoy https://t.co/Iyj2B5JMA0

[Alice B. Popejoy, PhD @AlicePopejoy]

Yikes! I wonder what part(s) of my genome encode social privilege, and those amazing mentoring relationships that helped me realize my potential as an academic researcher…? Holy hell we need to wake up and smell the wishful thinking amidst wafts of putrid familial confounding.

[Tobias Wolfram @_twolfram]

1/ Excited to share our new #GWAS preprint on the genetics of occupational status using data from @uk_biobank that finally completes the genomic SES-triad of Education, Income, and Occupation! Find the preprint here: https://t.co/mJmMkyoiwt 🧬📊👩‍🏫👨‍🔧👩‍💼

[Alice B. Popejoy, PhD @AlicePopejoy]

@ikingjordan @thebirdmaniac @DialecticBio À la Dobzhansky: we agree ✨
« Conflating these two distinct and independent concepts – human genetic diversity [genomic information] and equality [to which we now often refer as ‘diversity/equity/inclusion’ & measure by race/ethnicity] is a category error that is best avoided. »

[Alice B. Popejoy, PhD @AlicePopejoy]

@ikingjordan @thebirdmaniac @DialecticBio Now, of course, the argument that there is no connection between common, global genomic variation and race categories is empirically demonstrable. Not to be confused with the connection between genetic ancestry and genomic variation. Ancestry is relative, as are population means.

[Alice B. Popejoy, PhD @AlicePopejoy]

@ikingjordan @thebirdmaniac @DialecticBio I’ve not heard claims of NO relationship between race categories and genetic ancestry categories. What is perhaps misunderstood (as such) is an appeal for us to examine how race-based typologies drive the construction of broad ‘ancestry’ groups w/ DNA data reduced to 2D clusters.

[Alice B. Popejoy, PhD @AlicePopejoy]

@ikingjordan @thebirdmaniac @DialecticBio Please read the response to this (co-signed by 67 academics): https://t.co/6H22LUlsmC. TL;DR “… finding genetic differences between individuals [is not the same as] *constructing* genetic differences across groups by making conscious choices about which types of groups matter.”

[Alice B. Popejoy, PhD @AlicePopejoy]

@FerVillanea A trustworthy, thoughtful scholar who has systematically considered, then written about, the relationship between morphometrics and phylogenetics. Who is Joe Felsenstein…? https://t.co/Nge1O00tko

[Alice B. Popejoy, PhD @AlicePopejoy]

All about gratitude …

[Matt Schnuck @mattschnuck]

A famous researcher predicts divorce with 91% accuracy.

He invented a game to protect against the #1 relationship killer.

Here it is (in 3 minutes):

[Alice B. Popejoy, PhD @AlicePopejoy]

Saving for late-night 👩‍💻

[Gon García-Castro 🦜 @gongcastro]

I needed to generate ROC curves for several multinomial {brms} models in #rstats, but couldn't find an off-the-shelf function for it.

I used {tidybayes} and {yardstick} to generate ROC curves from the expected posterior predictions. Still in progress!
https://t.co/OBB8qx9lgZ

[Joanna Karolina Malinowska @jk_malinowska]

Our new paper (Malinowska & Żuradzki @incet_uj) is now published in OA:
https://t.co/1WNNGmaLHG
We reconstructed the theoretical background assumptions about racial ontology which researchers implicitly presume in their studies with the aid of a sample of recent papers...

[Alice B. Popejoy, PhD @AlicePopejoy]

@jk_malinowska @incet_uj @gravesjl55 @ByeonJulia @DaveSer89 Thank you for sharing, I look forward to reading!

[Alice B. Popejoy, PhD @AlicePopejoy]

@CartneyAnn Don’t give up! Despite most mentors telling you to get into a box and to stay there until you get a “real job”, in truth, the only folks who are sure never to get a faculty job are those who stop trying. @ucdavis is interdisciplinary by design, so that is considered a strength!

[Alice B. Popejoy, PhD @AlicePopejoy]

“Perhaps the most long-standing failure within genomics research is the lack of studies in populations of non-European ancestry, mirroring the systemic bias in biomedical research and society at large.” TY @genandgenes for dropping much-needed truth bombs, as usual!

[Genevieve Wojcik, PhD MHS @genandgenes]

As a preview for the recent Global Biobank Meta-analysis Initiative (GBMI) pubs, I wrote an epidemiologist's bingo card of:

🪐Why sample size matters (or doesn't)
✨How we're doing better on diversity (or aren't)
🏔What "tall" data will offer (or won't)

https://t.co/TV3txXfulK

[Dr. Dr. Desi (she/her) @native4data]

Riddle me this: if one is hired as part of an Indigenous diversity cluster & after it comes to light that you aren’t in fact an Indig person as you’ve claimed & you built a career on this lie, what happens? At a public land grant institution on tribal lands? This isn’t made up.

[Alice B. Popejoy, PhD @AlicePopejoy]

Right.

[Prof Nichola Raihani @nicholaraihani]

Very confused about how Elsevier want people to answer this 'Inclusionary Data Collection' question... I mean surely there is only one right answer?!