Topaz Altman

MD/PhD, Neurologist in Sheba Medical Center and Lecturer at Tel Aviv University

[Topaz Altman @AltmanTopaz]

It's finally out! Happy to announce the publication of my final PhD paper with @LabPerlson in @NatureComms. Together with @ArielIonescu we tried to unravel the biological mechanism underlying TDP-43 mediated #NMJ disruption in #ALS. https://t.co/v3WQueOVyE

[Perlson lab @LabPerlson]

Thrilled to share our new work in Nature Neuroscience!

Together with amazing collaborators and led by Ariel Ionescu, we discovered that muscle-derived miR-126 controls local axonal TDP-43 synthesis and protects neuromuscular junctions in ALS.

https://t.co/FMksQim7eF

[Topaz Altman @AltmanTopaz]

@ArielIonescu @NatureNeuro @LabPerlson Amazing Ari!
Hope this will generate waves in the field as it should!

[Topaz Altman @AltmanTopaz]

This landmark work—led by the amazing @ArielIonescu after nearly a decade of effort—sheds light on key mechanisms driving #ALS.
We hope these discoveries bring the #ALS field a step closer to effective treatments for this devastating disease.
More Here: https://t.co/XsyFKFaq0k

[Ariel Ionescu @ArielIonescu]

Thrilled to share that my postdoc reserach about #TDP-43 local synthesis in #ALS is now published in @NatureNeuro!
Muscle-derived miR-126 regulates TDP-43 axonal local synthesis and NMJ integrity in ALS models | Nature Neuroscience
@LabPerlson

More details in thread.

[Topaz Altman @AltmanTopaz]

🚨 Thrilled to share our @LabPerlson @ArielIonescu paper in Nature Neuroscience! 🚨For the first time, we show that TDP-43 pathology is also present in ALS patients with SOD1 mutations!
👉 https://t.co/idLy4njprr

[Ariel Ionescu @ArielIonescu]

Thrilled to share that my postdoc reserach about #TDP-43 local synthesis in #ALS is now published in @NatureNeuro!
Muscle-derived miR-126 regulates TDP-43 axonal local synthesis and NMJ integrity in ALS models | Nature Neuroscience
@LabPerlson

More details in thread.

[ShorterLab @ShorterLab]

Muscle-derived miR-126 regulates TDP-43 axonal local synthesis and NMJ integrity in ALS models, exciting work form @LabPerlson! https://t.co/RtsFrAnTgt

[Topaz Altman @AltmanTopaz]

@inna_slutsky @AlLeN_OtNa_85 @LeoreHeim @LeeSusman @of_sagol @TAUMedFaculty Great work Inna and the team!

[Topaz Altman @AltmanTopaz]

@GoldbergLab Deeply sorry for your loss Josh
תנצב"ה

[Topaz Altman @AltmanTopaz]

@shkedio מזל טוב!

[Shai Davidai @ShaiDavidai]

Hundreds of Jewish students at @Columbia just published one of the most incredible student letters I have ever read.

It's not only magnificently written, but it also clearly articulates their experiences on campus for the past six months.

Their letter tells the story of what's it like being a Jewish student right now better than any professor like myself could ever do.

Please take 4-5 minutes to read their letter.

Give Jewish students a voice.

https://t.co/nsWNScaoZS

[Topaz Altman @AltmanTopaz]

@The_SERIOus_Dr @theSeriousLab Very cool! Congrats Andrea and the team👏👏

[John Spencer @SpencerGuard]

IMO Israel has implemented more measure to prevent civilian casualties in urban warfare than any other military in the history of war. This includes many measure the U.S. has (or has not) taken in wars & battles but also many measures no military in the world has ever taken. 🧵

[ShipofTheseus @JewishSpaceLazr]

Israel journalist @Roi_Yanovsky just published an amazing piece in Hebrew about what Gaza is REALLY like, based on his personal observations there. Here is an English translation that you NEED to read🧵

100 reserve days officially ended yesterday. Some initial insights:

[Topaz Altman @AltmanTopaz]

@eLife @OdedRechavi Finally some moral clarity. Thank you eLife

[Topaz Altman @AltmanTopaz]

@Meng2Fu @OdedRechavi @eLife Thank you for this post🙏

[Topaz Altman @AltmanTopaz]

@alessio_vagnoni Thank you Alessio
Much appreciated, I hope we will be back to normal reality soon

[Ella Ke @EllaTravelsLove]

Tonight is the 4th night our babies will spend in Gaza.

We do not know if they were harmed, injured, or even if they are still alive.

This is the time to support Israel. Do everything you can to save our children, elders, men, and women from Hamas, a terrorist ISIS-like organization.

Don't look away.

Please share this.

#HamasISIS

[Topaz Altman @AltmanTopaz]

@IdoWolf1 תודה עידו על המאמר, עושה סדר ומדייק ברוב הנקודות. נקודת מחלוקת משמעותית בקרב הרופאים (בעיקר צעירים) היא הפרדת המועצה המדעית מהר"י ומתן תגמול הולם על הוראה ובחינה. צריך לעשות שיח משותף וכנה בנושא, כולל עם ארגון מרשם. לפני שטוענים בפני המדינה חייבים לבנות קונצנזוס שלנו הרופאים.

[Topaz Altman @AltmanTopaz]

@DrorMevorach https://t.co/CjqauQTxXy

[Topaz Altman @AltmanTopaz]

@DrorMevorach יש גם למודרנה חיסון לCMV לנשים בהריון שנמצא כבר בניסוי קליני בפאזה שלישית. יכול להיות לו אימפקט עצום על מומים מולדים