Ana Maria Fernandez

Statistical Genetics & Common Psychiatric Disorders. general health & science. some political data science when the mood strikes #R user

[Ana Maria Fernandez @AnaMariaFernand]

@starsandrobots Little Women, but more importantly, make sure they tour the Alcott House!

[Ana Maria Fernandez @AnaMariaFernand]

@ent3c I read this as a solution for unlivable-in-the-US salaries following years of training in $24k-40k roles to pass licensure exams for the profession as a whole with high student loan debt to income ratio (3:1) and society’s general stigma of therapy but love of coaching.

[Ana Maria Fernandez @AnaMariaFernand]

@mja Hmm. I have to say this jives with my experience. I definitely had lower productivity and more errors in LaTeX. Also more imposter syndrome

[Heredity @HeredityJournal]

A collection in honour of Bill Hill including his work published in Heredity over the past 50 years, along with papers published in Heredity in the past two years that have cited some of his seminal work.
https://t.co/JUQNiGoOwd

#popgen #quantgen @GenSocUK

[Ana Maria Fernandez @AnaMariaFernand]

@mja Ooof. This decision would overwhelm me 😂

[The Hoarse Whisperer @TheRealHoarse]

Taylor Swift has 87.3 million followers on Twitter - the exact same number as Trump.

This is the first campaign ad she has ever given permission to use her music.

#onlytheyoung

[Stan Lewis @StanLewis_]

Since aquariums are shut down, they let penguins wander around the place and it's honestly the news we need to see.

[NowThis Impact @nowthisimpact]

‘We have a system that is fundamentally broken.’ — Rep. @AOC is explaining just how f*cked campaign finance laws really are

[Ana Maria Fernandez @AnaMariaFernand]

@cathrynlewis @mja @PGCgenetics Seconding this -- Mark’s thoughtfulness, work ethic & calm organizational shepherding of the data is invaluable. Always been my friend & mentor & spotted these traits (& his talent for posing good questions that can be tested!) the day I met him in 2010. ⭐️ treat to work with

[Andrew Gelman et al. @StatModeling]

The necessity—and the difficulty—of admitting failure in research and clinical practice https://t.co/3X5YDsnNbv

[J. Craig Venter Institute @JCVenterInst]

Celebrating 18 years since completing the first draft sequence of the human genome. #NationalDNADay #DNADay #DNADay18

[Kindra Crick 🧩🧠🧬 @K_Crick]

Odile Crick, my grandmother, drew the first published diagram of #DNA

It was 65 years ago #onthisday, as a diagram in the first of the three papers published in @nature on the structure of DNA. ( Watson & Crick, Wilkins et al, Franklin & Gosling)

#SciArt ✨ #Scicomm #DNADay

[Ben Vincent @benjvincent]

THREAD: Since she’s about to close out #Dros18, I want to talk about @TingWu_Lab and Ting’s personal impact on me and the greater scientific community because informal mentors are incredibly important and she’s one of the best. 1/10

[Kaitlin Samocha @ksamocha]

Assuming the concern is that ML will focus on differences between batches. Happy to be corrected.

[Kaitlin Samocha @ksamocha]

Wray (@WrayNaomi) #GBD18: Reality of disease datasets: usually a meta-analysis of many cohorts. This makes it hard for machine learning to be applied.

[Kaitlin Samocha @ksamocha]

Wray (@WrayNaomi) #GBD18: Suggests investing in reference samples (like gene expression) for integration with GWAS results. Wants more samples collected with more phenotype information.

[Alexander Arguello @NeuroMinded]

In 60 secs @WrayNaomi clears up confusion about additivity, epistasis and polygenicity. Additive effects measured at population level, epistatic effects apparent at individual level. #GBD18

[Kaitlin Samocha @ksamocha]

Brennand #GBD18: hiPSC NPCs and cancer cell line drug signatures differed in genes associated with SCZ via common and rare variation.

Take home from this early work: if you are going to do a drug screen, do it in the right cells.

[Kaitlin Samocha @ksamocha]

Webber #GBD18: Three cases vs three controls — single cell sequencing. Disaster 1: three plates failed and so only 26% of cells passed QC. Disaster 2: one of the cases had a different condition. But still had 50 patient cells that were deeply sequenced.

[Kaitlin Samocha @ksamocha]

Stefánsson #GBD18: When sequencing genomes of individuals from Iceland, found on average 65 de novo variants, which means 1 in 10 individuals have a de novo LoF. Highlights that this means ~1/20 have a de novo LoF in a gene expressed in the brain.

https://t.co/T3Mzo0e8ep