Andrew Wood

Research group at the University of Edinburgh using genome editing and targeted protein degradation to study genetic disease and therapy

[Andrew Wood @AndrewWoodLab]

Today in @NatureGenet, we report a saturation genome editing study that systematically dissects the degron of β-Catenin: one of the most frequently mutated regions of the cancer genome. Collab with @kiddevonline and @DeryaDOzdemir, among many others

https://t.co/ZWiRwpwgpH

[Michel Goedert @MichelGoed]

Out now. A collaboration with Sofia Lövestam, Masato Hasegawa and Sjors Scheres. We report that tau filaments extracted from the brains of individuals with Alzheimer’s disease and corticobasal degeneration breed true in the brains of wild-type mice. https://t.co/hAgJiZhBFY

[Ed Reznik @EdReznik]

Incredibly excited to report today on the determinants of toxicity to systemic therapy in cancer patients. Led by many including Alex Guo, Feiyang Huang, Saksham Mohan, River Walser, and the fearless @ZiadBakouny. Co-led by Wes Tansey and Jian Carrot-Zhang https://t.co/axflh9pMRS

[Andrew Wood @AndrewWoodLab]

Our latest, out today in Cell Chemical Biology:

“Oncogene activation mechanism determines the limits of targeted protein degradation”

https://t.co/qO0huDTPgW

[Andrew Wood @AndrewWoodLab]

@mbeisen Coldplagiarism

[Andrew Wood @AndrewWoodLab]

@mbeisen Faith no more of a comment than a question

[Minczuk Lab @mito_gene]

We're hiring a Postdoctoral Research Associate at @MRC_MBU Cambridge

Join our @ARIA_research Precision Mitochondria project with Bitrobius Genetics to develop novel technologies for mitochondrial DNA delivery and genome engineering

🔗 https://t.co/ISoi2qEhBR

Please share! 🙏

[Andrew Wood @AndrewWoodLab]

This reveals a synthesis‑dependent ceiling on degradation, with implications for:
• interpreting preclinical degrader data
• resistance mechanisms
• genotype‑guided therapy design

[Andrew Wood @AndrewWoodLab]

🔬 New lab preprint: How does the mode of oncogene activation shape PROTAC efficacy?

Led by Evelina Gudauskaite, we ask whether stabilising mutations vs transcriptional upregulation have distinct consequences for targeted protein degradation.

https://t.co/vH8Dcud4yg.

[Andrew Wood @AndrewWoodLab]

Using a controlled cellular system (dTAG + TetOn3G), we found:

✅ Stabilising mutations don’t limit PROTAC action—degradation resets protein levels to the same baseline.

❌ Increased transcription raises target protein levels both pre‑ and post‑treatment.

[Wnt UK @UK_Wnt]

Beautiful new UK Wnt paper out now in @NatureGenet by Peter Hohenstein @AndrewWoodLab and Derya Ozdemir @UniLeidenNews @EdinburghUni @kocuniversity characterising the molecular/functional impact of numerous CTNNB1 mutational variants in human cancer.

https://t.co/SH4wwOmOJv

[Andrew Wood @AndrewWoodLab]

@MazharAdli @DeryaDOzdemir Thanks for the kind words @MazharAdli!

[nature @Nature]

Nature research paper: Hepatic zonation determines tumorigenic potential of mutant β-catenin

https://t.co/xGmCI4wJ8I

[Alexander Stark @AlexanderStark8]

Major new direction in the @stark_lab: hacking human cell biology with pathogen effectors (eORFs) - amazing collaboration with @mike_tilapia lab. Huge congrats to first authors Tomas & He & all co-authors! Check out the pre-print on @biorxivpreprint https://t.co/deg699JIWi

[Mike Gallagher @GeneticsMike7]

1/ Happy to share important work done with my co-author Andrew Khalil in the labs of Rudolf Jaenisch @WhiteheadInst @MITBiology @MIT and Dave Mooney @Harvard @wyssinstitute trying to assess and fix the major problem of transgene silencing in human ESC/iPSC based work

[Andrew Leduc @_AndrewLeduc]

The big one is finally out!! In this paper, we set out to provide insight into the fundamental question;

How do the individual cells from complex tissues regulate their proteomes?

Brief summary of our findings 👇
https://t.co/4dRXpGJTGn

[Andrew Wood @AndrewWoodLab]

Nice write up on the @MRCMouseNetwork website, highlighting the awesome work of first author Gillian Taylor, is available here: https://t.co/NWKh4XWDZV

[Andrew Wood @AndrewWoodLab]

Our manuscript characterising tissue-specific consequences of tagged protein fusions in CRISPR-engineered mice is now online @PLOSGenetics. https://t.co/walorzG7qO. Thanks again to all coauthors, reviewers and editors for a smooth publication process.

[Andrew Wood @AndrewWoodLab]

Happy to share our latest work and first manuscript from the Degron Tagging Cluster @MRCMouseNetwork. If you work with protein tags, particularly in tissue biology models, this should be of interest.

https://t.co/0FaWILmgUx

[Moutushi Islam, PhD @MoutushiIslam1]

Know it before you tag it!! 🏷️🧬