Andrew Wood

Research group at the University of Edinburgh using genome editing and targeted protein degradation to study genetic disease and therapy

[Andrew Wood @AndrewWoodLab]

Today in @NatureGenet, we report a saturation genome editing study that systematically dissects the degron of β-Catenin: one of the most frequently mutated regions of the cancer genome. Collab with @kiddevonline and @DeryaDOzdemir, among many others

https://t.co/ZWiRwpwgpH

[Andrew Wood @AndrewWoodLab]

This reveals a synthesis‑dependent ceiling on degradation, with implications for:
• interpreting preclinical degrader data
• resistance mechanisms
• genotype‑guided therapy design

[Andrew Wood @AndrewWoodLab]

🔬 New lab preprint: How does the mode of oncogene activation shape PROTAC efficacy?

Led by Evelina Gudauskaite, we ask whether stabilising mutations vs transcriptional upregulation have distinct consequences for targeted protein degradation.

https://t.co/vH8Dcud4yg.

[Andrew Wood @AndrewWoodLab]

Using a controlled cellular system (dTAG + TetOn3G), we found:

✅ Stabilising mutations don’t limit PROTAC action—degradation resets protein levels to the same baseline.

❌ Increased transcription raises target protein levels both pre‑ and post‑treatment.

[Wnt UK @UK_Wnt]

Beautiful new UK Wnt paper out now in @NatureGenet by Peter Hohenstein @AndrewWoodLab and Derya Ozdemir @UniLeidenNews @EdinburghUni @kocuniversity characterising the molecular/functional impact of numerous CTNNB1 mutational variants in human cancer.

https://t.co/SH4wwOmOJv

[Andrew Wood @AndrewWoodLab]

@MazharAdli @DeryaDOzdemir Thanks for the kind words @MazharAdli!

[nature @Nature]

Nature research paper: Hepatic zonation determines tumorigenic potential of mutant β-catenin

https://t.co/xGmCI4wJ8I

[Alexander Stark @AlexanderStark8]

Major new direction in the @stark_lab: hacking human cell biology with pathogen effectors (eORFs) - amazing collaboration with @mike_tilapia lab. Huge congrats to first authors Tomas & He & all co-authors! Check out the pre-print on @biorxivpreprint https://t.co/deg699JIWi

[Mike Gallagher @GeneticsMike7]

1/ Happy to share important work done with my co-author Andrew Khalil in the labs of Rudolf Jaenisch @WhiteheadInst @MITBiology @MIT and Dave Mooney @Harvard @wyssinstitute trying to assess and fix the major problem of transgene silencing in human ESC/iPSC based work

[Andrew Leduc @_AndrewLeduc]

The big one is finally out!! In this paper, we set out to provide insight into the fundamental question;

How do the individual cells from complex tissues regulate their proteomes?

Brief summary of our findings 👇
https://t.co/4dRXpGJTGn

[Andrew Wood @AndrewWoodLab]

Nice write up on the @MRCMouseNetwork website, highlighting the awesome work of first author Gillian Taylor, is available here: https://t.co/NWKh4XWDZV

[Andrew Wood @AndrewWoodLab]

Our manuscript characterising tissue-specific consequences of tagged protein fusions in CRISPR-engineered mice is now online @PLOSGenetics. https://t.co/walorzG7qO. Thanks again to all coauthors, reviewers and editors for a smooth publication process.

[Andrew Wood @AndrewWoodLab]

Happy to share our latest work and first manuscript from the Degron Tagging Cluster @MRCMouseNetwork. If you work with protein tags, particularly in tissue biology models, this should be of interest.

https://t.co/0FaWILmgUx

[Moutushi Islam, PhD @MoutushiIslam1]

Know it before you tag it!! 🏷️🧬

[Andrew Wood @AndrewWoodLab]

We characterise two underlying mechanisms with opposing effects on protein stability and explain their tissue-specificity, providing a rational basis for improved experimental design. Congrats to 1st author Gillian Taylor and all who contributed. Feedback welcome!

[Andrew Wood @AndrewWoodLab]

Happy to share our latest work and first manuscript from the Degron Tagging Cluster @MRCMouseNetwork. If you work with protein tags, particularly in tissue biology models, this should be of interest.

https://t.co/0FaWILmgUx

[Andrew Wood @AndrewWoodLab]

By surveying a series of CRISPR-engineered mice, we found that tags often change protein expression in some tissues but have little effect, or even opposite effects, in others. Why?

[Andrew Wood @AndrewWoodLab]

@MAChristoLab @lwalport @TeresaBertran @RobertW48522313 @VeniPap @IVAramburu @TessaSwanton Even I remember this one! Congrats Maria and all coauthors.

[Liver Growth and Cancer Lab @boulter_lab]

🚨We are recruiting🚨. We have a @UKRI_News funded position available @mrc_hgu for a Research Assistant working on Polycystic Liver Disease with @scott_wad_dell
& @Mill_lab ! If you are interested in #organoids, #singlecell and disease modelling then apply! job: 11386 & link👇