Mike Gallagher

Geneticist and stem cell biologist studying epigenetics and neurodegeneration @WhiteheadInst @MIT. B.S. @Muhlenberg Ph.D. @Penn

[Mike Gallagher @GeneticsMike7]

1/ Happy to share important work done with my co-author Andrew Khalil in the labs of Rudolf Jaenisch @WhiteheadInst @MITBiology @MIT and Dave Mooney @Harvard @wyssinstitute trying to assess and fix the major problem of transgene silencing in human ESC/iPSC based work

[Mike Gallagher @GeneticsMike7]

@mbeisen @addictedtoigno1 I’d pick randomly, as these clusters don’t mean anything 😉

[Mike Gallagher @GeneticsMike7]

@SunnyLedfurd Studio or live? They’ve never been a very good studio band.

[Mike Gallagher @GeneticsMike7]

@HeckYaDangIt @SunnyLedfurd 2/ ppl who heard 3 radio songs that are mediocre and don’t realize that most fans don’t consider the albums to be very relevant. They’re a live show band, that’s where all the fans sign up.

[Mike Gallagher @GeneticsMike7]

@HeckYaDangIt @SunnyLedfurd 1/ Dave is a great and unique songwriter, even if you don’t like his style. His rhythm guitar playing is crazy good and interesting, and the band has generally been fantastic musically. They’re probably one of the best live bands of the ‘90’s and 2000’s. A lot of hate comes from

[Mike Gallagher @GeneticsMike7]

@CoreyMiles__ @lpachter Generally in my field everyone is fed up with having to focus on getting scarce funding and publishing for the sake of publishing, and would rather spend time thinking, reading and doing research organically, which is why they pursued their careers in the first place.

[Mike Gallagher @GeneticsMike7]

@MS23840062 @SGRodriques @razibkhan The goal of science is to produce knowledge. Curing diseases is an application of knowledge from a subset of biological research.

[Mike Gallagher @GeneticsMike7]

@anshulkundaje @SashaGusevPosts What do you think should be done? E.g. should funders start considering preprint servers as equivalent to all journals, and consider all journals as equivalent? What about those who employ and promote scientists?

[Mike Gallagher @GeneticsMike7]

@anshulkundaje @SashaGusevPosts I supposed nothing will really change unless funders and employers abandon journal names as having any relevance.

[Mike Gallagher @GeneticsMike7]

@anshulkundaje @SashaGusevPosts Agreed, but who interprets peer review in that way? I think science would be a lot healthier if only society or other non-profit journals existed, but we don’t live in that world, so the question is what to do in the world that we live in.

[Mike Gallagher @GeneticsMike7]

@SashaGusevPosts @anshulkundaje 2/ the supp material text, is absurd. This can be the case for many different reasons, such as details that aren’t necessary for one’s interpretation, inability to assess the details due to lack of experience or expertise, or a table that is there if you need it, but you don’t.

[Mike Gallagher @GeneticsMike7]

@SashaGusevPosts @anshulkundaje 1/ Correct, although I don’t think it’s egocentrism. Scientists read what they need to to extract the meaning that is useful for them. It changes throughout one’s career, and can differ by field and other factors. The idea that anyone needs to read every word of a paper, inc all

[Mike Gallagher @GeneticsMike7]

@dioscuri I think this more a consequence of insufficient funding rather than an intrinsic problem with academia

[Mike Gallagher @GeneticsMike7]

@ladanuzhna I think this is driven by the realization in the 2010s that amyloid and tau pathology precede dementia by 5-20+ yrs. So all the trails may have indeed targeted them too late.

[Mike Gallagher @GeneticsMike7]

@donsin4 @LocasaleLab No one is panicking. Some people are pretending that people are panicking so they have something to be mad about.

[Mike Gallagher @GeneticsMike7]

@parmita Thermocyclers, fluorescent microscopes, microarrays, qPCR machines, mass spec, Nanopore, flow cytometry, cryo-EM, a million high-throughput/automated assays, tons of super-res microscopes

[Mike Gallagher @GeneticsMike7]

@kwharrison13 @n_skene What does it mean that “each disease we can’t cure has the same shape”?

[Mike Gallagher @GeneticsMike7]

@KenCaptn20114 @open_vaet @nuchdig @Kevin_McKernan @basenji_times @KUPERWASSERLAB @jsm2334 @IamBrookJackson Well I disagree, but that’s ok!

[Mike Gallagher @GeneticsMike7]

@KenCaptn20114 No, the vast majority of studies were not performed by pharma. Most studies are conducted by academic scientists around the world, and they generally confirms the findings from the initial clinical trials.

[Mike Gallagher @GeneticsMike7]

@KenCaptn20114 This is the website that stores all studies published in the world. It has nothing to do with the government.

[Mike Gallagher @GeneticsMike7]

@KenCaptn20114 Here’s a more up to date review. https://t.co/SId8Ivb7UQ

[Mike Gallagher @GeneticsMike7]

@KenCaptn20114 Here’s a review for Pfizer, Moderna and Astra Zeneca. https://t.co/vYuIa0qa0r