Andrew Siladi

Molecular biologist. Following biotech R&D. “Very stable genius”

[Andrew Siladi @Andrew_Siladi]

Very excited to share our new work on perturbing WDR5 function in Burkitt lymphoma cells. Long overdue, this is my first publication 😅. Here, we demonstrate WIN site inhibition disables only a subset of WDR5 function. https://t.co/FWL6fd8eVB /1

[Andrew Siladi @Andrew_Siladi]

@Pharmdca @JamesFlowerIII identification, screen for hits, pharmacokinetic optimization, preclinical trials etc to reach IND then average clinical trials take up to ten years. How will streamlining review get full timeline down to 1-2 years. It can help trials not blow up entirely sure

[Andrew Siladi @Andrew_Siladi]

@Pharmdca @JamesFlowerIII You said go from 10-15 years down to 1-2 years then mention EMA approval being 210 days. The EMA process is streamlined but still relies on trial data. Probably twice as fast as FDA but both cases you still must do~ 5 years of basic science, which does not involve FDA, for target

[Brian Grieb MD, PhD @BGriebMD]

Newest manuscript from @TanseyTweets on examining WDR5 inhibitors in MLLr leukemia!

@VanderbiltCDB @VUmedicine @VUMC_Cancer @Nicky_eleuteri @Andrew_Siladi @andicflorian @VUMCHemOnc

[BBC News (UK) @BBCNews]

Blood test for more than 50 types of cancer shows real promise in major NHS trial, say researchers https://t.co/eayWk0gugv

[Sam Baker @sam_baker]

You also might be inclined to believe this not because you “hate Elizabeth Holmes,” but rather because she did in fact perpetrate an elaborate scheme to defraud investors, as established by a mountain of bulletproof journalism, federal investigations and a criminal trial.

[Andrew Siladi @Andrew_Siladi]

One of the pillars of jazz has passed on. Paving the way for artists like Miles Davis and Bill Evans to sound the way they did, Ahmad Jamal shaped the genre and relaxed it with genius zen.

[The Jazz Estate @thejazzestate]

Ahmad Jamal performing live in Paris, France in 1971.

[Phil Williams @PhilNvestigates]

WATCH: To better understand the background that led to #TheTennesseeThree, take a look at my 2020 investigation of a 2014 gun law that has led to many deaths.
TN Republicans don't want to penalize people for leaving guns unlocked in cars because "Tennesseans love their guns."

[Phil Williams @PhilNvestigates]

WATCH: To better understand Democratic frustrations surrounding how business is conducted in Tennessee's GOP supermajority House, watch this segment from our award-winning Revealed investigation - long before #TheTennesseeThree made national news. (Please like and share.) 1/2

[philip lewis @Phil_Lewis_]

Wow: Tennessee state Rep. Justin Jones, one of the Dems that the GOP is trying to expel from state legislature to protesting gun violence, calls out his colleagues on the floor

‘For years, one of your colleagues, an admitted child molester, sat in this chamber – no expulsion’

[Andrew Siladi @Andrew_Siladi]

Despite what some might have you believe, meta-analyses are not a “gold standard”

[Paul Knoepfler @pknoepfler]

ICYMI: Fun stuff. A look @davidasinclair mouse anti-aging @CellCellPress pub in context of 10 yrs of in vivo reprogramming. Information theory of aging vs. role of mutations & #stemcell theory https://t.co/iBcd14NBaM

[Jay Bradner, M.D. @jaybradner]

Until that time when direct MYC inhibition is achieved, we compete MYC away from critical effector proteins, here WDR5. A terrific chemical probe herein, another WD40 repeat protein in the win column.

[Andrew Siladi @Andrew_Siladi]

Allis was a beacon of light illuminating the field of chromatin biology. His contributions to deciphering the histone code undoubtedly place him in line for a Nobel. He was even first to demonstrate WDR5 binding H3 and the effects of WDR5 depletion, central elements of my thesis.

[Rockefeller University @RockefellerUniv]

It is with heavy hearts that we announce the passing of our beloved colleague and friend, C. David Allis. Aside from his groundbreaking contributions to biomedical science, David will be remembered for his warmth, humility, and relentless optimism.

[Andrew Siladi @Andrew_Siladi]

Cool stuff, let the controversy over H3K4me3 dependent transcription continue!

[Jamie Hackett @hackettlab]

📢Preprint drop! -Are chromatin modifications a cause or consequence of transcription? (or both)

How do DNA motifs affect the function of marks? Can combinatorial modifications synergise?

We present our epigenome editing study, & unexpected findings👇+🧵
https://t.co/Mrq6HWvgsh

[Kevin Folta @kevinfolta]

This is the problem. When the @guardian publishes distortions of science, even reliable writers like @Brad_Dress don't talk to scientists frist-- they repeat the falsehoods in visible venues. Let's get it straight folks. @thehill https://t.co/5Tp9CocFN4

[Neil deGrasse Tyson @neiltyson]

Just Released

Deepest-ever view of the cosmos from @NASAWebb. The spiked objects are local stars in our own Galaxy. ignore them. Everything else is an entire galaxy. Many distort into arcs, revealing spacetime curvature from the gravity of a galaxy cluster in the image's center.

[Andrew Siladi @Andrew_Siladi]

@asonfrio Adaptability to different niches

[Andrew Siladi @Andrew_Siladi]

@asonfrio Not an expert on this but I think current evidence suggests Eukaryotes evolved from Archea because have a similar system for replicating DNA. I would agree that the symbiotic relationships between microbiota and eukaryotes facilitate diversification of life by increasing euks

[Andrew Siladi @Andrew_Siladi]

@JacobPlieth @KwiatBerlin My wife works in PR and told me about it but I didn’t see anything